Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post-PDT, and limited photodynamic efficiency. Herein, we report photo-triggered porphyrin polyelectrolyte nanoassembling (photo-triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal-ligand coordination. The polyelectrolyte-based PPN exhibits good biocompatibility, bestows unique "confining isolated" inner microenvironment fully overcoming π-π stacking porphyrins with significant efficiency (123-fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed-form, could use light as specific trigger modulate closed- open-form, manipulate

Language: Английский

Donor Modulation Brings All-In-One Phototheranostics for NIR-II Imaging-Guided Type-I Photodynamic/Photothermal Synergistic Cancer Therapy DOI Creative Commons
Yuxin Ren, Xinyi Zhang, Ling Li

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel all-in-one phototheranostics OTAB was synthesized by modifying the donor and regulating band gap for NIR-II imaging-guided synergistic type-I PDT/PTT therapy.

Language: Английский

Citations

1
From X‐ To J‐Aggregation: Subtly Managing Intermolecular Interactions for Superior Phototheranostics with Precise 1064 nm Excitation DOI Open Access
Jun Tang,

Leilei Si,

Yigang Wang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract The stacking mode in aggregate state results from a delicate balance of supramolecular interactions, which closely affects the optoelectronic properties organic π‐conjugated systems. Then, managing these interactions is crucial for advancing phototheranostics, yet remains challenging. A subtle strategy involving peripheral phenyl groups debuted herein to transform X‐aggregated SQ‐H into J‐aggregated SQ‐Ph, reorienting intermolecular dipole while rationally modulating π–π interactions. Co‐assembled with liposomes (DSPE‐PEG2000), SQ‐Ph nanoparticles (NPs) exhibit low toxicity, superior biocompatibility, and bathochromic shift 1064 nm match‐excited NIR‐II region, fluorescence brightness (ε Φ ) 4129 M −1 cm photothermal conversion efficiency (PCE) 48.3%. Preliminary vivo experiments demonstrate that NPs achieve signal‐to‐background ratio (SBR) up 14.29 imaging (FLI), enabling highly efficient therapy (PTT) tumors guided by combined photoacoustic (PAI). This study not only enriches J‐aggregation library but also provides paradigm optimizing photosensitizers at level.

Language: Английский

Citations

0
Multi-dimensional donor engineering of NIR-II AIEgens for multimodal phototheranostics of orthotopic breast cancer DOI
Yuan Tao, Jie Cui, Jun Zhu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123193 - 123193

Published: Feb. 19, 2025

Language: Английский

Citations

0
Win–Win Integration of Genetically Engineered Cellular Nanovesicles with High‐Absorbing Multimodal Phototheranostic Molecules for Boosted Cancer Photo‐Immunotherapy DOI Open Access
Xue Li, Xinwen Ou, Zeng‐Ming Yang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Photo-immunotherapy is one of the most promising cancer treatment strategies. As immunotherapeutic agents, immune checkpoint blockade antibodies against programmed cell death protein 1 (PD-1) or ligand (PD-L1) exhibit substantial potential, but have to face non-specific distribution and subsequent immune-related adverse events. Meanwhile, high-performance phototheranostic agents concurrently possessing multiple modalities high light-harvesting capacity are really attractive highly desired as touching modules. Herein, a win-win strategy that integrates molecule design targeted module preparation developed construct high-powered photo-immunotherapy systems. Specifically, agent (AOTTIT) displaying typical aggregation-induced fluorescence extending second near-infrared II window, well outstanding reactive oxygen species heat production first obtained via ingenious design. Notably, AOTTIT exhibits record molar extinction coefficient among reported organic multimodal molecules. PD-1 genetically engineered membrane-derived nanovesicles (PD-1/CMNVs) prepared both nanocarriers camouflage nanoparticles, yielding multifunctional photo-immunotherapeutic (CMNPs/PD-1) with tumor-specific active homologous targeting ability. The distinct suppression primary metastatic lung tumors after only once tumor substantiated synergistically strengthened efficiency this strategy.

Language: Английский

Citations

0
Recent Advances in Aggregation-Induced Emission Bioconjugates DOI
Guiquan Zhang,

Daming Zhou,

Rong Hu

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Fluorescence imaging technology is playing increasing roles in modern personalized and precision medicine. Thanks to their excellent photophysical properties, organic luminogens featuring aggregation-induced emission (AIE) characteristics (AIEgens) have attracted considerable attention over the past two decades. Because of superior biocompatibility, ease processing functionalization, water solubility, high responsiveness, exceptional signal-to-noise ratio (SNR) for biotargets, AIE bioconjugates, formed by covalently linking AIEgens with biomolecules, emerged as an ideal candidate bioapplications. In this review, we summarize progress preparation, application bioconjugates last five years. Moreover, challenges opportunities are also briefly discussed.

Language: Английский

Citations

0
Icing on the Cake: Integrating Optical Fiber with Second Near‐Infrared Aggregation‐Induced Emission Luminogen for Exceptional Phototheranostics of Bladder Cancer DOI
Jun Zhu, Yong‐Guan Zhu, Jianhong Huang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Bladder cancer is a common urological malignancy characterized by high morbidity, recurrence rate and mortality, imposing heavy burdens on patients mentally financially. The research pioneers diagnostic therapeutic approach that integrates second near‐infrared (NIR‐II) multimodal phototheranostic platform with optical fiber‐mediated interventional phototherapy strategy, to implement comprehensive diagnosis “inside‐out” treatment of bladder cancer. proposed molecule, namely BTO‐TTQ, elaborately designed through electron donor/π‐bridge engineering demonstrates satisfying NIR‐II emission aggregation‐induced features, photothermal conversion efficiency, prominent generation type I reactive oxygen species. Quantum chemical calculations molecular dynamics simulations are employed deeply elucidate the energy dissipation pathways excited state impact intramolecular motion their photophysical properties. Furthermore, under guidance fluorescent‐photoacoustic‐photothermal trimodal imaging, hyaluronic acid‐modified BTO‐TTQ nanoparticles exhibit exceptional performance in for air‐pouch models. This study thus brings new insight into development superior versatile phototheranostics clinical theranostics

Language: Английский

Citations

0
AIEgen Photosensitizer-Loaded Silica Nanoparticles for Lysosomes-Targeting Photodynamic Therapy in Tumor DOI
Mingyan Zhao, Wenguang Zhang, Miaozhuang Fan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(20), P. 23504 - 23512

Published: Oct. 10, 2024

Aggregation-induced emission (AIE)-based photosensitizers (PSs) are well-known for their exceptional biocompatibility and high irradiation-induced reactive oxygen species (ROS) generation capacity, making them promising candidates photodynamic therapy (PDT). In antitumor treatment, enhancing the spatiotemporal specificity of AIEgen PSs can maximize efficacy suppressing tumor cells. Lysosomes, as digestive cellular organelles, be perturbed by various external stimuli, leading to dysfunction even apoptosis. This makes ideal targets effective precise PDT. this study, an AIE photosensitizer MEO-TTMN (MT) was encapsulated with a silica shell develop AIE-based nanoparticles (NPs), MT@SiO2-MP NPs, The absorption peaks these NPs were at 513 675 nm, respectively. Upon irradiation, exhibited stronger ROS capacity when compared commercial chlorin e6 (Ce6). decoration morpholine group on surface facilitated accumulate specifically in lysosomes. A level proven situ generated lysosomal sites which led damage lysosomes subsequent apoptosis vivo PDT tumor-bearing mouse demonstrated that significantly suppressed growth tumor. work has provided efficient lysosome-targeting improve accuracy, is beneficial cancer field nanomedicine research.

Language: Английский

Citations

1
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI Open Access

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post‐PDT, and limited photodynamic efficiency. Herein, we report photo‐triggered porphyrin polyelectrolyte nanoassembling (photo‐triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal‐ligand coordination. The polyelectrolyte‐based PPN exhibits good biocompatibility, bestows unique “confining isolated” inner microenvironment fully overcoming π–π stacking porphyrins with significant efficiency (123‐fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed‐form, could use light as specific trigger modulate closed‐ open‐form, manipulate 1 O 2 generation three stages: pre‐PDT (quenching generation), during (activating post‐PDT (silencing generation). This de novo strategy first time realized remotely manipulating boosting PDT, well resolving critical general challenges side effects from phototoxicity.

Language: Английский

Citations

0
Photo‐Triggered Fluorescence Polyelectrolyte Nanoassemblies: Manipulate and Boost Singlet Oxygen in Photodynamic Therapy DOI

Yongkang Yao,

Shangjun Chen, Chenxu Yan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Photodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for cancer treatment. However, there exist two major problems hindering PDT applications: the nonspecific phototoxicity requiring patients to stay in dark post-PDT, and limited photodynamic efficiency. Herein, we report photo-triggered porphyrin polyelectrolyte nanoassembling (photo-triggered PPN) strategy, which photosensitizer photoswitchable energy accepter are assembled into micelles by combined force of charge interaction metal-ligand coordination. The polyelectrolyte-based PPN exhibits good biocompatibility, bestows unique "confining isolated" inner microenvironment fully overcoming π-π stacking porphyrins with significant efficiency (123-fold enhancement). Due high Förster resonance transfer (FRET) (91.5 %) between photoswitch closed-form, could use light as specific trigger modulate closed- open-form, manipulate

Language: Английский

Citations

0