Two-pronged nanostrategy for treating ALI and blocking pulmonary fibrosis through intracellular/extracellular synergistic intervention to restore mitochondrial homeostasis and inhibit inflammation
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 159903 - 159903
Опубликована: Янв. 1, 2025
Язык: Английский
Nanodrug Delivery System for Precision Treatment of Pulmonary Fibrosis
Precision medicine and engineering.,
Год журнала:
2025,
Номер
unknown, С. 100025 - 100025
Опубликована: Март 1, 2025
Язык: Английский
Targeted Drug Delivery System for Pulmonary Fibrosis: Design and Development of Biomaterials
BIO Integration,
Год журнала:
2025,
Номер
6(1)
Опубликована: Янв. 1, 2025
Pulmonary
fibrosis
(PF)
is
a
progressive
interstitial
lung
disease
characterized
by
excessive
extracellular
matrix
deposition
and
tissue
scarring,
leading
to
impaired
function
respiratory
failure.
Although
current
treatments,
such
as
pirfenidone
nintedanib,
slow
progression,
they
fail
completely
halt
or
reverse
fibrosis.
Therefore,
innovative
therapeutic
strategies
are
needed.
Targeted
drug
delivery
systems
(TDDSs)
emerging
promising
solutions.
Biomaterials
play
critical
roles
in
these
enhancing
specificity,
availability,
efficacy,
while
minimizing
systemic
toxicity.
The
most
notable
biomaterials
include
nanotechnology-based
systems,
including
liposomes
polymeric
nanoparticles,
which
facilitate
penetration
release
fibrotic
tissues.
Hydrogels
have
three-dimensional
structures
providing
controlled
sustained
at
inflammation
sites,
therefore
particularly
valuable
PF
treatment.
Furthermore,
biological
carriers
stem
cells
vesicles
biocompatibility
anti-inflammatory
effects
that
improve
outcomes.
Despite
the
potential
of
clinical
translation
hindered
several
challenges,
immune
clearance,
stability
platforms,
optimization
retention
within
diseased
Interdisciplinary
approaches
integrating
precision
medicine
with
advancements
may
provide
solutions
opening
new
avenues
for
This
review
discusses
developments
targeted
PF,
emphasizing
importance
biomaterials,
mechanisms
barriers
involved
pulmonary
delivery,
future
perspectives
overcoming
limitations.
ultimate
goal
patient
outcomes
revolutionizing
approach
treatment
through
advanced
technologies.
Язык: Английский
Nanomaterials reshape the pulmonary mechanical microenvironment: novel therapeutic strategies for respiratory diseases
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Май 2, 2025
Respiratory
diseases,
including
chronic
obstructive
pulmonary
disease
(COPD),
idiopathic
fibrosis
(IPF),
and
lung
cancer,
exhibit
elevated
death
rates
pathological
intricacy,
requiring
advancements
that
surpass
the
constraints
of
traditional
therapies.
This
study
comprehensively
outlines
novel
applications
nanomaterials
in
respiratory
medicine
by
accurately
modulating
mechanical
microenvironment,
encompassing
alveolar
surface
tension,
extracellular
matrix
rigidity,
immune-fibroblast
interaction
network.
The
precise
delivery,
stimuli-responsive
characteristics,
biomimetic
design
markedly
improve
drug
concentration
at
lesion
site
mitigate
fibrosis,
inflammation,
malignant
tumor
advancement
disrupting
signaling
pathways.
clarifies
their
multifaceted
benefits
treating
COPD,
IPF,
decreased
systemic
toxicity
improved
spatiotemporal
control.
Nonetheless,
clinical
translation
continues
to
encounter
obstacles,
impediments
large-scale
production,
inadequate
compatibility
with
breathing
devices,
disputes
concerning
long-term
biosafety.
In
future,
amalgamation
precision
medicine,
adaptive
smart
materials,
multi-omics
artificial
intelligence
technologies
will
facilitate
development
individualized
diagnostic
therapeutic
systems,
establishing
a
paradigm
for
proactive
management
disorders.
review
offers
essential
theoretical
foundations
technical
approaches
practical
application
enhancement
techniques
medicine.
Язык: Английский