Nanomaterials reshape the pulmonary mechanical microenvironment: novel therapeutic strategies for respiratory diseases DOI Creative Commons
Lizhen Chen, Peiyan Zheng,

Qi Cai

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 2, 2025

Respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF), and lung cancer, exhibit elevated death rates pathological intricacy, requiring advancements that surpass the constraints of traditional therapies. This study comprehensively outlines novel applications nanomaterials in respiratory medicine by accurately modulating mechanical microenvironment, encompassing alveolar surface tension, extracellular matrix rigidity, immune-fibroblast interaction network. The precise delivery, stimuli-responsive characteristics, biomimetic design markedly improve drug concentration at lesion site mitigate fibrosis, inflammation, malignant tumor advancement disrupting signaling pathways. clarifies their multifaceted benefits treating COPD, IPF, decreased systemic toxicity improved spatiotemporal control. Nonetheless, clinical translation continues to encounter obstacles, impediments large-scale production, inadequate compatibility with breathing devices, disputes concerning long-term biosafety. In future, amalgamation precision medicine, adaptive smart materials, multi-omics artificial intelligence technologies will facilitate development individualized diagnostic therapeutic systems, establishing a paradigm for proactive management disorders. review offers essential theoretical foundations technical approaches practical application enhancement techniques medicine.

Language: Английский

Two-pronged nanostrategy for treating ALI and blocking pulmonary fibrosis through intracellular/extracellular synergistic intervention to restore mitochondrial homeostasis and inhibit inflammation DOI

Jiahui Yan,

Xueping Sun,

Yanan Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159903 - 159903

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanodrug Delivery System for Precision Treatment of Pulmonary Fibrosis DOI Creative Commons
Xianhao Yi, Xinru Zhang, Y. Guan

et al.

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100025 - 100025

Published: March 1, 2025

Language: Английский

Citations

0
Targeted Drug Delivery System for Pulmonary Fibrosis: Design and Development of Biomaterials DOI Creative Commons
Jinsha Liu,

Zifeng Pan,

Aatif Khan

et al.

BIO Integration, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by excessive extracellular matrix deposition and tissue scarring, leading to impaired function respiratory failure. Although current treatments, such as pirfenidone nintedanib, slow progression, they fail completely halt or reverse fibrosis. Therefore, innovative therapeutic strategies are needed. Targeted drug delivery systems (TDDSs) emerging promising solutions. Biomaterials play critical roles in these enhancing specificity, availability, efficacy, while minimizing systemic toxicity. The most notable biomaterials include nanotechnology-based systems, including liposomes polymeric nanoparticles, which facilitate penetration release fibrotic tissues. Hydrogels have three-dimensional structures providing controlled sustained at inflammation sites, therefore particularly valuable PF treatment. Furthermore, biological carriers stem cells vesicles biocompatibility anti-inflammatory effects that improve outcomes. Despite the potential of clinical translation hindered several challenges, immune clearance, stability platforms, optimization retention within diseased Interdisciplinary approaches integrating precision medicine with advancements may provide solutions opening new avenues for This review discusses developments targeted PF, emphasizing importance biomaterials, mechanisms barriers involved pulmonary delivery, future perspectives overcoming limitations. ultimate goal patient outcomes revolutionizing approach treatment through advanced technologies.

Language: Английский

Citations

0
Nanomaterials reshape the pulmonary mechanical microenvironment: novel therapeutic strategies for respiratory diseases DOI Creative Commons
Lizhen Chen, Peiyan Zheng,

Qi Cai

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 2, 2025

Respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF), and lung cancer, exhibit elevated death rates pathological intricacy, requiring advancements that surpass the constraints of traditional therapies. This study comprehensively outlines novel applications nanomaterials in respiratory medicine by accurately modulating mechanical microenvironment, encompassing alveolar surface tension, extracellular matrix rigidity, immune-fibroblast interaction network. The precise delivery, stimuli-responsive characteristics, biomimetic design markedly improve drug concentration at lesion site mitigate fibrosis, inflammation, malignant tumor advancement disrupting signaling pathways. clarifies their multifaceted benefits treating COPD, IPF, decreased systemic toxicity improved spatiotemporal control. Nonetheless, clinical translation continues to encounter obstacles, impediments large-scale production, inadequate compatibility with breathing devices, disputes concerning long-term biosafety. In future, amalgamation precision medicine, adaptive smart materials, multi-omics artificial intelligence technologies will facilitate development individualized diagnostic therapeutic systems, establishing a paradigm for proactive management disorders. review offers essential theoretical foundations technical approaches practical application enhancement techniques medicine.

Language: Английский

Citations

0