Applied Materials Today, Год журнала: 2024, Номер 42, С. 102546 - 102546
Опубликована: Дек. 19, 2024
Язык: Английский
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for regeneration, making electrical materials a promising therapy. This review provides comprehensive overview of the role bioelectric signals cells, alongside recent advancements biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, zwitterionic hydrogels. It further investigates impact these biomaterials as well applications both exogenous stimulation (ES) mechanisms underlying ES‐induced cellular molecular responses. Finally, underscores future directions ES systems tissue engineering, emphasizing critical importance integrating structural integrity, mechanical properties, signal delivery into intelligent implantable scaffolds.
Язык: Английский
Процитировано
4
Gels, Год журнала: 2025, Номер 11(4), С. 258 - 258
Опубликована: Апрель 1, 2025
Conductive hydrogels, integrating high conductivity, mechanical flexibility, and biocompatibility, have emerged as crucial materials driving the evolution of next-generation wearable sensors. Their unique ability to establish seamless interfaces with biological tissues enables real-time acquisition physiological signals, external stimuli, even therapeutic feedback, paving way for intelligent health monitoring personalized medical interventions. To fully harness their potential, significant efforts been dedicated tailoring conductive networks, properties, environmental stability these hydrogels through rational design systematic optimization. This review comprehensively summarizes strategies categorized into metal-based, carbon-based, polymer-based, ionic, hybrid systems. For each type, highlights structural principles, conductivity enhancement, approaches simultaneously enhance robustness long-term under complex environments. Furthermore, emerging applications in sensing systems are thoroughly discussed, covering signal monitoring, mechano-responsive platforms, closed-loop diagnostic–therapeutic Finally, this identifies key challenges offers future perspectives guide development multifunctional, intelligent, scalable hydrogel sensors, accelerating translation advanced flexible electronics smart healthcare technologies.
Язык: Английский
Процитировано
3
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 24, 2025
Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical the form of self-power vivo during initial postoperative stages when patients have limited mobility remains challenging. In this study, we developed a 3D-printed self-powered composite scaffold composed shape memory polyurethane elastomers (SMPU) polyvinylidene fluoride (PVDF) piezoelectric nanofibers. The demonstrates excellent performance, allowing for minimally invasive implantation. During process, can provide mechanical force PVDF nanofibers generate charge. Therefore, was achieved through integration process effects, it be used period. Additionally, output voltage under continuous stimulation, indicating that apply sustained rehabilitation exercises regain mobility. Both cell experiments animal studies confirmed effectively immune microenvironment enhance osteogenesis. This study successfully achieves by integrating which is expected an effective repair strategy tissue engineering.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 10, 2025
Orthopedic diseases pose significant challenges to public health due their high prevalence, debilitating effects, and limited treatment options. Additionally, orthopedic tumors, such as osteosarcoma, chondrosarcoma, Ewing sarcoma, further complicate the landscape. Current therapies, including pharmacological treatments joint replacement, address symptoms but fail promote true tissue regeneration. Cell-based which have shown successful clinical results in cancers other diseases, emerged a promising solution repair damaged tissues restore function tumors. This review discusses advances potential application of cell therapy for with particular focus on osteoarthritis, bone fractures, cartilage degeneration, We explore mesenchymal stromal cells (MSCs), chondrocyte transplantation, engineered immune induced pluripotent stem enhance regeneration by modulating response addressing inflammation. Ultimately, integration cutting-edge therapy, modulation, molecular targeting strategies could revolutionize providing hope patients seeking long-term solutions conditions.
Язык: Английский
Процитировано
1
Macromolecular Bioscience, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Osteoporotic bone regeneration is challenging due to impaired formation. Tetrahedral DNA nanostructures (TDN), promising nucleic acid nanomaterials, have garnered attention for their potential in osteoporotic mandibular owing ability enhance cellular activity and promote osteogenic differentiation. Osteoblasts play a critical role regeneration; however, intracellular delivery of TDN into osteoblasts remains difficult. In this study, novel osteoblast-targeted CH6 aptamer-functionalized (TDN-CH6) aimed develop regeneration. This results demonstrated that TDN-CH6 exhibits superior osteoblast specificity efficient recruitment fracture sites. Furthermore, significantly enhances differentiation compared alone. Notably, Gelatin Methacryloyl (GelMA) hydrogels incorporating shows improved biological performance are favorable regeneration, suggesting platform represents strategy addressing complex defects.
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract Dynamic wound care presents significant challenges for conventional dressings due to the complex environment and high‐frequency motion associated with such injuries. In this study, a multifunctional photo‐crosslinked piezoelectric hydrogel (OAPS) is developed, incorporating heterojunction Se‐doped KH570 modified BaTiO 3 nanoparticles (Se‐BT570 NPs) as core component, designed address antimicrobial monitoring needs in care, particularly at sites movement. The OAPS effectively utilizes inherent dynamic wounds, enhancing efficacy enabling real‐time of human health statuses. This achieved through synergistic effects properties nano‐heterostructures that enable self‐driven charge transfer. Such integration allows dual applications both diagnosis treatment. Experimental results demonstrated exhibits excellent mechanical strength adhesive properties, adapting motion. Additionally, can be activated by environments perform functions, significantly accelerating healing an rate 99.75%. study highlights potential nanomaterials healing, offering promising strategy managing complex, care.
Язык: Английский
Процитировано
0
Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112361 - 112361
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер unknown, С. 123288 - 123288
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Март 30, 2025
Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.
Язык: Английский
Процитировано
0