Nanomedicine Penetrating Blood‐Pancreas Barrier for Effective Treatment of Acute Pancreatitis
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Acute
pancreatitis
(AP)
is
a
primary
contributor
to
hospitalization
and
in‐hospital
mortality
worldwide.
Targeted
elimination
of
mitochondrial
reactive
oxygen
species
(mtROS)
within
pancreatic
acinar
cells
(PACs)
represents
an
ideal
strategy
for
treating
AP.
However,
existing
drugs
fail
overcome
the
physiological
barriers
pancreas
effectively
reach
PACs
mitochondria
due
trade‐off
between
conventional
positively
charged
mitochondrial‐targeting
groups
their
inability
penetrate
blood‐pancreas
barrier
(BPB).
Here,
tungsten‐based
heteropolyacid
nano‐antioxidant
(mTWNDs)
introduced,
co‐modified
with
tannic
acid
(TA)
melanin,
enabling
site‐specific
clearance
mtROS
in
PACs,
offering
highly
effective
treatment
TA
exhibits
strong
affinity
proline‐rich
type
III
collagen
outer
membrane
protein
TOM20.
This
unique
property
allows
mTWNDs
traverse
damaged
BPB‐exposing
subsequently
targeted
elimination.
In
cerulein‐induced
AP
mice,
reversed
at
1/50th
dose
N‐acetylcysteine,
suppressing
apoptosis
inflammation
by
blocking
stimulator
interferon
genes
pathway
activation
macrophage.
study
establishes
antioxidant
nanomedicine
treatment.
Язык: Английский
Metformin-induced precise targeted inhibition of ischemic neuronal death by a programable endogenous ROS-responsive nanoprodrug
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 162106 - 162106
Опубликована: Апрель 1, 2025
Язык: Английский
Engineered tantalum sulfide nanosheets for effective acute liver injury treatment by regulating oxidative stress and inflammation
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown, С. 137596 - 137596
Опубликована: Апрель 1, 2025
Язык: Английский
TFAM Deficiency Triggers mtDNA Leakage and cGAS-STING-Mediated Intestinal Ischemia–Reperfusion Injury
Inflammation,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Intestinal
Ischemia-Reperfusion
(IIR)
injury
is
a
common
clinical
pathophysiological
condition,
yet
the
complex
molecular
mechanisms
underlying
its
pathology
remain
incompletely
understood.
This
study
aims
to
explore
precise
of
IIR
injury,
with
focus
on
role
cGAS-STING
signaling
pathway.
Using
mouse
model
and
hypoxia/reoxygenation
(HR)
in
HT-29
cells
small
intestinal
organoids,
we
observed
that
significantly
induces
oxidative
stress
activates
pathway,
which
associated
exacerbated
tissue
damage
enhanced
inflammatory
responses.
Further
investigation
revealed
mitochondrial
DNA
(mtDNA)
leakage
critical
trigger
for
activation
The
introduction
exogenous
mtDNA
into
activated
STING
pathway
cellular
damage.
In
contrast,
depletion
intracellular
effectively
suppressed
HR-induced
Mechanistically,
found
downregulates
transcription
factor
A
(TFAM),
subsequently
affects
stability,
promoting
release
cytoplasm
triggering
Overexpression
TFAM
stabilized
mtDNA,
reduced
accumulation
cytoplasmic
inhibited
activation,
alleviated
Moreover,
STING-deficient
mice
exhibited
inflammation,
less
damage,
improved
survival
rates
following
IIR,
highlighting
IIR-induced
injury.
Our
findings
elucidate
close
association
between
stress,
IIR.
downregulation
are
key
driving
this
activation.
Importantly,
plays
crucial
stabilizing
reducing
during
These
results
not
only
deepen
our
understanding
pathogenesis
but
also
provide
potential
therapeutic
strategies
targeting
treating
IIR-related
diseases.
Язык: Английский
Protein-based nano delivery systems focusing on protein materials, fabrication strategies and applications in ischemic stroke intervention: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
311, С. 143645 - 143645
Опубликована: Апрель 29, 2025
Язык: Английский
Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 2, 2025
Background
Cerebral
ischemia-reperfusion
injury
(CIRI)
is
a
secondary
brain
that
occurs
after
thrombolysis
and
primary
cause
of
death
in
ischemic
stroke
patients.
Antioxidants
effectively
reduce
oxidative
stress
are
an
efficient
treatment
approach
for
CIRI.
Here,
novel
diimide
compound
was
synthesized
using
the
chemical
structure
previously
designed
anti-inflammatory
skeletons.
Methods
results
The
antioxidant
activities
five
compounds
(Z1–Z5)
were
preliminarily
evaluated
hydrogen
peroxide-induced
PC12
cell
damage
model,
which
Z3
exhibited
best
effect,
even
exceeding
positive
control
(tert-butylhydroquinone).
Enrichment
analysis
network
targeting
pharmacology
methods
predicted
seven
candidate
core
target
genes
Of
these
targets,
computer
molecular
docking
has
strongest
binding
affinity
nuclear
factor
erythroid
2-related
(Nrf2).
MTT
colony
formation
assays,
reactive
oxygen
species
analysis,
immunofluorescence,
immunoblotting
experiments
verified
reduced
to
play
protective
role
via
Nrf2/hemoxygenase
1
(HO-1)
pathway.
effect
vivo
explored
through
TTC
staining
neurobehavioral
scoring
CIRI
model
mice.
Conclusion
This
study
provides
new
drug
development
strategy
CIRI,
offering
ideas
design
antioxidants.
Язык: Английский
In situ implantable and reactive oxygen species responsive hydrogel loaded with minocycline for functional rehabilitation of traumatic brain injury
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 164322 - 164322
Опубликована: Май 1, 2025
Язык: Английский
Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats
Saudi Pharmaceutical Journal,
Год журнала:
2024,
Номер
32(12), С. 102210 - 102210
Опубликована: Ноя. 26, 2024
Phenylacetylglycine
(PAGly)
is
a
small
molecule
derived
from
phenylalanine
in
the
gut
Язык: Английский