Nanomedicine Penetrating Blood‐Pancreas Barrier for Effective Treatment of Acute Pancreatitis

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Acute pancreatitis (AP) is a primary contributor to hospitalization and in‐hospital mortality worldwide. Targeted elimination of mitochondrial reactive oxygen species (mtROS) within pancreatic acinar cells (PACs) represents an ideal strategy for treating AP. However, existing drugs fail overcome the physiological barriers pancreas effectively reach PACs mitochondria due trade‐off between conventional positively charged mitochondrial‐targeting groups their inability penetrate blood‐pancreas barrier (BPB). Here, tungsten‐based heteropolyacid nano‐antioxidant (mTWNDs) introduced, co‐modified with tannic acid (TA) melanin, enabling site‐specific clearance mtROS in PACs, offering highly effective treatment TA exhibits strong affinity proline‐rich type III collagen outer membrane protein TOM20. This unique property allows mTWNDs traverse damaged BPB‐exposing subsequently targeted elimination. In cerulein‐induced AP mice, reversed at 1/50th dose N‐acetylcysteine, suppressing apoptosis inflammation by blocking stimulator interferon genes pathway activation macrophage. study establishes antioxidant nanomedicine treatment.

Language: Английский

---

Metformin-induced precise targeted inhibition of ischemic neuronal death by a programable endogenous ROS-responsive nanoprodrug

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162106 - 162106

Published: April 1, 2025

Language: Английский

---

Engineered tantalum sulfide nanosheets for effective acute liver injury treatment by regulating oxidative stress and inflammation

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137596 - 137596

Published: April 1, 2025

Language: Английский

---

TFAM Deficiency Triggers mtDNA Leakage and cGAS-STING-Mediated Intestinal Ischemia–Reperfusion Injury

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Intestinal Ischemia-Reperfusion (IIR) injury is a common clinical pathophysiological condition, yet the complex molecular mechanisms underlying its pathology remain incompletely understood. This study aims to explore precise of IIR injury, with focus on role cGAS-STING signaling pathway. Using mouse model and hypoxia/reoxygenation (HR) in HT-29 cells small intestinal organoids, we observed that significantly induces oxidative stress activates pathway, which associated exacerbated tissue damage enhanced inflammatory responses. Further investigation revealed mitochondrial DNA (mtDNA) leakage critical trigger for activation The introduction exogenous mtDNA into activated STING pathway cellular damage. In contrast, depletion intracellular effectively suppressed HR-induced Mechanistically, found downregulates transcription factor A (TFAM), subsequently affects stability, promoting release cytoplasm triggering Overexpression TFAM stabilized mtDNA, reduced accumulation cytoplasmic inhibited activation, alleviated Moreover, STING-deficient mice exhibited inflammation, less damage, improved survival rates following IIR, highlighting IIR-induced injury. Our findings elucidate close association between stress, IIR. downregulation are key driving this activation. Importantly, plays crucial stabilizing reducing during These results not only deepen our understanding pathogenesis but also provide potential therapeutic strategies targeting treating IIR-related diseases.

Language: Английский

---

Protein-based nano delivery systems focusing on protein materials, fabrication strategies and applications in ischemic stroke intervention: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143645 - 143645

Published: April 29, 2025

Language: Английский

---

Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Background Cerebral ischemia-reperfusion injury (CIRI) is a secondary brain that occurs after thrombolysis and primary cause of death in ischemic stroke patients. Antioxidants effectively reduce oxidative stress are an efficient treatment approach for CIRI. Here, novel diimide compound was synthesized using the chemical structure previously designed anti-inflammatory skeletons. Methods results The antioxidant activities five compounds (Z1–Z5) were preliminarily evaluated hydrogen peroxide-induced PC12 cell damage model, which Z3 exhibited best effect, even exceeding positive control (tert-butylhydroquinone). Enrichment analysis network targeting pharmacology methods predicted seven candidate core target genes Of these targets, computer molecular docking has strongest binding affinity nuclear factor erythroid 2-related (Nrf2). MTT colony formation assays, reactive oxygen species analysis, immunofluorescence, immunoblotting experiments verified reduced to play protective role via Nrf2/hemoxygenase 1 (HO-1) pathway. effect vivo explored through TTC staining neurobehavioral scoring CIRI model mice. Conclusion This study provides new drug development strategy CIRI, offering ideas design antioxidants.

Language: Английский

---

Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats

Saudi Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 32(12), P. 102210 - 102210

Published: Nov. 26, 2024

Phenylacetylglycine (PAGly) is a small molecule derived from phenylalanine in the gut

Language: Английский

---