Conductive Hydrogels with Topographical Geometry and Mechanical Robustness for Enhanced Peripheral Nerve Regeneration DOI
Yinghui Feng,

Liangjie Shan,

Yafei Wang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Nerve guidance conduits (NGCs) emerge as a promising solution for nerve regeneration; however, conventional NGCs fail to fulfill the requirements peripheral regeneration, which are subjected periodical yet vigorous stretching, bending, and compression. Here, we developed fatigue-resistant conductive hydrogel-based NGC by integrating topographical geometry, enhanced electroactivity, superior fatigue resistance within one unit. The hydrogel, consisting of PVA matrix with PEDOT:PSS filler, features alignment that promotes axonal growth achieves threshold over 500 J/m2, making it well-suited sciatic repairing. Phase segregation PEDOT chains enhances its electrical conductivity (>500 S/m) mitigates interfacial impedance mismatch, allowing high-efficiency bioelectrical signal transmission. In vivo studies on rat injury model corroborate accelerated regeneration through improved motor function recovery efficient electrophysiological These findings establish our synergy topographical, mechanical, engineering.

Язык: Английский

Conducting Hydrogel‐Based Neural Biointerfacing Technologies DOI Open Access
Pei Zhang, Yifan Yang,

Zhaobo Li

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Язык: Английский

Процитировано

1

Tribology in Nature: Inspirations for Advanced Lubrication Materials DOI Open Access
Chenxi Qin, Hao Yang, Yaqiong Lü

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Friction‐induced energy consumption is a significant global concern, driving researchers to explore advanced lubrication materials. In nature, vital for the life cycle of animals, plants, and humans, playing key roles in movement, predation, decomposition. After billions years evolution, natural exhibits remarkable professionalism, high efficiency, durability, intelligence, offering valuable insights designing This review focuses on mechanisms organisms advancements biomimetic soft matter It begins by summarizing common biological behaviors their underlying mechanisms, followed current design strategies The then outlines development performance these materials based different strategies. Finally, it discusses potential research directions prospects will be resource advancing

Язык: Английский

Процитировано

1

Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects DOI Creative Commons

Yanai Chen,

Yijia Cao,

Peixin Cui

и другие.

Biomimetics, Год журнала: 2025, Номер 10(4), С. 206 - 206

Опубликована: Март 26, 2025

The application background of mussel-inspired materials is based on the unique underwater adhesive ability marine mussels, which has inspired researchers to develop bionic with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus able form non-covalent forces a variety surfaces, are critical for mussel's adhesion enable material dissipate energy repair itself under external forces. Mussel-inspired hydrogels ideal medical due their physical chemical properties, such as excellent tissue hemostasis bacteriostasis, biosafety, plasticity. This paper reviewed chitosan, cellulose, hyaluronic acid, gelatin, alginate, other biomedical discussed advanced functions wound dressings, including antibacterial, anti-inflammatory, antioxidant hemostasis, transport, self-healing, stimulating response, so on. At same time, technical challenges limitations biomimetic hydrogel applications were further discussed, its potential solutions future research developments field biomedicine highlighted.

Язык: Английский

Процитировано

0

Directional Vaporization‐Driven Alignment in Printable Muscle‐Mimetic Anisotropic Protein Materials DOI

Siying Zhao,

Zhe Lu, Kunlun Li

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Abstract Biomimetic materials hold significant potential for a wide range of applications, yet developing straightforward and versatile methods to create muscle‐mimetic, high‐performance protein with anisotropic properties remains major challenge. In this study, simple general strategy is presented alignment driven by directional airflow, enabling the design printable, muscle‐mimetic proteins. By utilizing airflow during hydrogel drying in combination rapid photochemistry, molecules align efficiently single direction. Similar natural muscle, mechanical these can be further enhanced through training, achieving remarkable strength up ≈8 MPa at 600% strain an anisotropy factor 3.0. This fabrication process compatible conventional printing techniques, allowing creation complex structures controlled tailored properties. Notably, exhibit biomimetic actuation (≈6 s) adaptability under physiological conditions. Their demonstrated proof‐of‐concept applications as artificial grippers vessel dilators, which remain stable months but degrade rapidly within hours after enzymatic treatment post‐therapy. directional‐airflow‐driven method, along resulting materials, offers promising implications fields, from medical devices adaptive technologies.

Язык: Английский

Процитировано

0

Tailoring of a specific pH-induced self-enhanced photothermal cellulose hydrogel for antibiotic-resistant bacteria-infected wound treatment DOI
Rimei Chen, Yonghui He,

Lingli Tian

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер 513, С. 163025 - 163025

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0

Conductive Hydrogels with Topographical Geometry and Mechanical Robustness for Enhanced Peripheral Nerve Regeneration DOI
Yinghui Feng,

Liangjie Shan,

Yafei Wang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Nerve guidance conduits (NGCs) emerge as a promising solution for nerve regeneration; however, conventional NGCs fail to fulfill the requirements peripheral regeneration, which are subjected periodical yet vigorous stretching, bending, and compression. Here, we developed fatigue-resistant conductive hydrogel-based NGC by integrating topographical geometry, enhanced electroactivity, superior fatigue resistance within one unit. The hydrogel, consisting of PVA matrix with PEDOT:PSS filler, features alignment that promotes axonal growth achieves threshold over 500 J/m2, making it well-suited sciatic repairing. Phase segregation PEDOT chains enhances its electrical conductivity (>500 S/m) mitigates interfacial impedance mismatch, allowing high-efficiency bioelectrical signal transmission. In vivo studies on rat injury model corroborate accelerated regeneration through improved motor function recovery efficient electrophysiological These findings establish our synergy topographical, mechanical, engineering.

Язык: Английский

Процитировано

0