Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 16, 2025
Diabetes
mellitus
is
a
prevalent
chronic
disease,
often
leading
to
complications,
with
wounds
being
among
the
most
challenging.
Impairment
of
CXCR4/CXCL12
signaling
pathway,
which
plays
key
role
in
cell
mobilization,
migration,
and
angiogenesis,
significantly
hampers
wound
healing
process
diabetic
patients.
Modulation
this
pathway
using
CXCR4-targeted
agents
has
shown
promise
restoring
repair
capabilities.
Additionally,
development
responsive
hydrogels
capable
adapting
external
stimuli
offers
powerful
platform
for
drug
delivery
management.
These
hydrogels,
when
loaded
CXCR4
agonists
or
antagonists,
enable
controlled
release
real-time
therapeutic
modulation.
Integrating
such
existing
strategies
may
provide
an
innovative
effective
solution
overcoming
challenges
associated
treatment.
Язык: Английский
PVA/HA@BT hydrogel with antioxidant and antibacterial abilities for accelerating diabetic wound healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
311, С. 143923 - 143923
Опубликована: Май 3, 2025
Язык: Английский
Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing
Mingyuan Zhao,
Jiawei Xiang,
Yuan Meng
и другие.
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
The
regulation
of
the
immune
microenvironment
is
a
key
component
wound
healing,
where
suitable
dressings
with
skin
immunoreactivity
can
favorably
affect
process
and
promote
repairing
progress.
Therefore,
we
developed
an
injectable
photo-cross-linkable
composite
hydrogel─oxidized
astragalus
polysaccharide
carboxymethyl
chitosan/sodium
methacrylated
alginate
magnesium
ions
hydrogel
(OAPS-CMC/SAMA-Mg2+,
OCS)
loaded
curcumin
(Cur)-encapsulated
Achyranthes
bidentata
supramolecular
self-assemblies
(NX
SSA)
(NX@Cur)─termed
OCS/NX@Cur
to
synergistically
accelerate
repair.
polysaccharide-dominated
matrix
provided
superior
anti-inflammatory
ability.
Meanwhile,
NX@Cur
strong
angiogenesis
accelerated
collagen
deposition.
In
cellular
experiments
rat
model
total
defects,
exhibited
anti-inflammatory,
antioxidant,
angiogenic
capabilities.
These
properties
modulated
inflammatory
environment
wound,
thereby
promoting
formation
granulation
tissue
neovascularization
accelerating
deposition
re-epithelialization.
conclusion,
showed
excellent
repair
capabilities,
providing
potential
therapeutic
option
for
combination
super
self-assembly
natural
hydrogels
Язык: Английский