Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing DOI

Mingyuan Zhao,

Jiawei Xiang,

Yuan Meng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

The regulation of the immune microenvironment is a key component wound healing, where suitable dressings with skin immunoreactivity can favorably affect process and promote repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide carboxymethyl chitosan/sodium methacrylated alginate magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate repair. polysaccharide-dominated matrix provided superior anti-inflammatory ability. Meanwhile, NX@Cur strong angiogenesis accelerated collagen deposition. In cellular experiments rat model total defects, exhibited anti-inflammatory, antioxidant, angiogenic capabilities. These properties modulated inflammatory environment wound, thereby promoting formation granulation tissue neovascularization accelerating deposition re-epithelialization. conclusion, showed excellent repair capabilities, providing potential therapeutic option for combination super self-assembly natural hydrogels

Language: Английский

Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations DOI Creative Commons
Lingli Wang,

Fengsong Nie,

Zhaoyu Lu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Diabetes mellitus is a prevalent chronic disease, often leading to complications, with wounds being among the most challenging. Impairment of CXCR4/CXCL12 signaling pathway, which plays key role in cell mobilization, migration, and angiogenesis, significantly hampers wound healing process diabetic patients. Modulation this pathway using CXCR4-targeted agents has shown promise restoring repair capabilities. Additionally, development responsive hydrogels capable adapting external stimuli offers powerful platform for drug delivery management. These hydrogels, when loaded CXCR4 agonists or antagonists, enable controlled release real-time therapeutic modulation. Integrating such existing strategies may provide an innovative effective solution overcoming challenges associated treatment.

Language: Английский

Citations

0
PVA/HA@BT hydrogel with antioxidant and antibacterial abilities for accelerating diabetic wound healing DOI
Rong Li, Yuwen Chen, Yuhang Zhou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143923 - 143923

Published: May 3, 2025

Language: Английский

Citations

0
Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing DOI

Mingyuan Zhao,

Jiawei Xiang,

Yuan Meng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

The regulation of the immune microenvironment is a key component wound healing, where suitable dressings with skin immunoreactivity can favorably affect process and promote repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide carboxymethyl chitosan/sodium methacrylated alginate magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate repair. polysaccharide-dominated matrix provided superior anti-inflammatory ability. Meanwhile, NX@Cur strong angiogenesis accelerated collagen deposition. In cellular experiments rat model total defects, exhibited anti-inflammatory, antioxidant, angiogenic capabilities. These properties modulated inflammatory environment wound, thereby promoting formation granulation tissue neovascularization accelerating deposition re-epithelialization. conclusion, showed excellent repair capabilities, providing potential therapeutic option for combination super self-assembly natural hydrogels

Language: Английский

Citations

0