Bio‐Integrated Microrobots: Fabrication, Actuation and Biomedical Applications
Опубликована: Март 13, 2025
ABSTRACT
Bio‐integrated
microrobots
(BIMs),
which
are
fabricated
with
biofriendly
materials,
biological
units
(e.g.
cells
or
biomolecules),
cell‐material
hybrids
have
emerged
as
a
promising
technology
for
minimally
invasive
biomedicine.
The
diminutive
size
and
flexible
structures
enable
BIMs
to
navigate
within
narrow,
deep,
challenging‐to‐reach
in
vivo
regions,
performing
biopsy,
diagnostic,
drug
delivery,
therapeutic
functions
minimal
invasiveness.
However,
the
clinical
deployment
of
is
highly
orchestrated
task
that
requires
consideration
material
properties,
structural
design,
locomotion,
observation,
outcomes,
side
effects
on
tissues,
etc.
In
this
review,
we
review
discuss
latest
advances
bio‐integrated
microrobot
domain,
evaluating
various
methods
associated
fabrication,
actuation,
implementation
biomedical
BIMs.
By
comparing
advantages
shortcomings
these
techniques,
highlights
challenges
future
trends
intelligent
microrobots,
huge
potential
Язык: Английский
Skeletal Muscle Tissue Engineering: from Tissue Regeneration to Biorobotics.
Cyborg and Bionic Systems,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 1, 2025
With
its
remarkable
adaptability,
energy
efficiency,
and
mechanical
compliance,
skeletal
muscle
is
a
powerful
source
of
inspiration
for
innovations
in
engineering
robotics.
Originally
driven
by
the
clinical
need
to
address
large
irreparable
defects,
tissue
(SMTE)
has
evolved
into
versatile
strategy
reaching
beyond
medical
applications
field
biorobotics.
This
review
highlights
recent
advancements
SMTE,
including
scaffold
design,
cell
sourcing,
usage
external
physicochemical
cues,
bioreactor
technologies.
Furthermore,
this
article
explores
emerging
synergies
between
SMTE
robotics,
focusing
on
use
robotic
systems
enhance
performance
development
biohybrid
devices
integrating
engineered
tissue.
These
interdisciplinary
approaches
aim
improve
functional
recovery
outcomes
while
inspiring
novel
technologies
at
intersection
regenerative
medicine.
Язык: Английский
Biosyncretic robotic systems: Comprehensive construction, application, and future challenges
Science China Technological Sciences,
Год журнала:
2025,
Номер
68(4)
Опубликована: Март 14, 2025
Язык: Английский
Modular Living Muscle‐Based Biomimetic Actuators for Biosyncretic Robots
Опубликована: Апрель 10, 2025
ABSTRACT
Biosyncretic
robots
that
integrate
living
materials
present
unique
advantages
for
advancing
robotic
research.
Compared
with
traditional
robots,
biosyncretic
offer
potential
benefits
such
as
higher
energy
efficiency
and
enhanced
biocompatibility.
Among
various
bioactuators,
skeletal
muscle
tissue
(SMT)
is
particularly
favored
its
scalability,
to
generate
high
driving
forces,
controllable
on/off
actuation.
However,
current
SMT
actuators
often
face
challenges,
including
a
limited
force
suboptimal
practical
designs,
which
may
impede
the
development
of
robots.
To
address
these
limitations,
this
work
proposes
method
fabricating
modular
actuators.
By
leveraging
biomimetic
design
structural
optimization,
contractile
performance
significantly
improved.
The
achieved
maximum
2.92
±
0.07
mN,
demonstrated
approximately
28%
strain
under
unloaded
conditions,
notably
exhibited
responsive
single‐twitch
contractions
electrical
stimulation
frequencies
up
10
Hz.
This
response
outperforms
most
existing
robot
studies.
In
addition,
highly
adaptable
can
be
easily
assembled
construct
human‐like
actuators,
convergent,
parallel,
bipennate
muscles.
integrating
rigid‐flexible
coupled
nonliving
structures,
SMT‐driven
caterpillar,
dolphin,
manta
ray
have
been
successfully
developed.
research
presents
an
innovative
approach
constructing
large,
high‐performance,
multifunctional
contributing
advancements
in
both
(or
biohybrid
robots)
engineering.
Язык: Английский
Clinical Translation of Inorganic Nanoparticles and Engineered Living Materials for Cancer Therapy
ChemPlusChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 11, 2024
A
wide
range
of
particle-based
nano-
to
microsystems
is
currently
under
investigation
for
potential
use
in
personalized
nanomedicine.
However,
only
a
small
fraction
these
innovations
likely
make
it
clinical
use.
In
this
concept
article,
we
start
by
discussing
the
applications
inorganic
nanoparticles
cancer
treatment
and
diagnosis,
shed
light
on
challenges
they
must
overcome
become
clinically
available.
second
part,
focus
engineered
living
materials,
which
have
begun
revolutionize
way
medical
interventions
could
be
performed.
Finally,
share
our
insights
opinions
explain
why,
despite
significant
advancements
research
technologies,
their
translation
practice
remains
limited.
Язык: Английский
Dynamic Electromechanical Co‐Stimulation Based Enhancement of Skeletal Muscle Tissues for Fast Biosyncretic Robots Actuation
Advanced Functional Materials,
Год журнала:
2024,
Номер
35(2)
Опубликована: Окт. 14, 2024
Abstract
Biosyncretic
robots
composed
of
living
and
synthetic
materials
have
garnered
significant
attention
due
to
their
high
energy
conversion
efficiency,
good
biocompatibility
human‐robot
interaction
safety.
Among
common
actuation
materials,
artificial
skeletal
muscle
tissue
(ASMT)
stands
out
for
its
size
scalability,
controllability,
potential
driving
force.
However,
the
low
differentiation
efficiency
myoblasts,
performance
ASMT
lags
behind
that
natural
tissue,
thereby
hindering
progress
biosyncretic
robots.
Here,
inspired
by
training
mode
human
muscle,
an
electromechanical
co‐stimulation
system
enhancing
ASMTs
is
proposed.
This
capable
simultaneously
applying
electrical
mechanical
stimulation
ASMTs.
Moreover,
resistance
can
be
dynamically
adjusted
during
growth
based
on
real‐time
measurements
contractile
force
ASMT.
The
results
show
enhanced
demonstrate
improved
actuate
a
robot
at
maximum
speed
2.38
mm
s
−1
,
which
faster
than
those
most
currently
reported
ASMT‐based
study
introduces
novel
approach
ASMTs,
with
substantial
implications
fields
engineering.
Язык: Английский