Cu-catalyzed three-component C-S-P coupling for the synthesis of trisubstituted allenyl phosphorothioates

Chinese Chemical Letters, Год журнала: 2024, Номер 35(12), С. 109617 - 109617

Опубликована: Фев. 20, 2024

Язык: Английский

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Pyrazolidinone-Aided Ru(II)-Catalyzed Regioselective C–H Annulation with Allenes

Organic Letters, Год журнала: 2024, Номер 26(21), С. 4480 - 4485

Опубликована: Май 20, 2024

Regioselective annulation of allenes via C–H activation represents an elegant synthetic approach toward the construction valuable scaffolds. Considering importance allenes, herein we developed unprecedented Ru(II)-catalyzed highly regioselective redox-neutral activation/(4 + 1)-annulation 1-arylpyrazolidinones employing allenyl acetates to access pyrazolo[1,2-a]indazol-1-one derivatives. Additionally, cyclic carbonates, which were never tested in activation, utilized construct a similar class heterocycles having pendent alcohol functionality. Notably, double functionalization was achieved by simple modification reaction conditions. The significance this methodology is underscored late-stage natural products, broad substrate scope, gram-scale synthesis, and postfunctionalizations.

Язык: Английский

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Ru(II)-Catalyzed Decarboxylative (4 + 2)-Annulation of Benzoic Acids and Benzamides with Propargyl Cyclic Carbonates

Organic Letters, Год журнала: 2024, Номер 26(36), С. 7590 - 7595

Опубликована: Сен. 3, 2024

Propargyl cyclic carbonates have emerged as versatile precursors in synthetic chemistry. However, their reactivity has so far been limited to transition metal-catalyzed substitution and cyclization reactions. Herein, we illustrate the successful employment of propargyl coupling partners Ru(II)-catalyzed C-H annulation benzoic acids benzamides. This approach allowed us access a broad range biologically relevant isocoumarin isoquinolinone derivatives good excellent yields, utilizing bench-stable easily accessible precursors. Preliminary mechanistic studies indicated that metalation step is both reversible rate-determining reaction pathway. Furthermore, utility developed methodology illustrated by scale-up postfunctionalization experiments.

Язык: Английский

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Functional CO2 based heterocycles as precursors in organic synthesis

Advances in catalysis, Год журнала: 2022, Номер unknown, С. 1 - 28

Опубликована: Янв. 1, 2022

Язык: Английский

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