European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(32)
Опубликована: Июль 6, 2023
Abstract
The
divergent
synthesis
of
dihydropyrimidouracil
and
pyrimidouracil
derivatives
from
N
‐uracil
amidines
tertiaryamines
by
an
oxidative
C(sp
3
)−
cleavage
cascade
cyclization
reaction
is
first
described.
This
transformation
enables
the
formation
new
2
bonds
via
selection
different
oxidation
conditions.
features
this
method
include
tunable
product
selectivity,
excellent
chemoselectivity,
readily
available
starting
materials,
broad
substrate
scope,
good
tolerance
functional
groups,
moderate
to
high
yields.
Organic Letters,
Год журнала:
2023,
Номер
25(47), С. 8451 - 8456
Опубликована: Ноя. 16, 2023
The
three-component
reactions
of
enaminones,
disulfides,
and
alcohols
for
the
synthesis
polyfunctionalized
alkenes
have
been
realized
via
C-H
C-N
bond
transformation
on
enaminones.
proceed
in
a
novel
"alkene-to-alkene"
difunctionalization
mode
without
using
any
transition
metal.
application
alkene
products
divergent
sulfenyl
heteroaryls,
including
sulfenylated
pyrazoles,
pyrimidines,
isoxazoles,
simple
annulation
has
also
verified.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2363 - 2369
Опубликована: Март 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(14), С. 3906 - 3912
Опубликована: Янв. 1, 2024
A
chemodivergent
and
skeleton-controllable
annulation
reactions
of
readily
available
o
-HPEs
aryldiazonium
salts
was
described
for
the
synthesis
highly
functionalized
pyridazine-fused
chromones
with
high
antiviral
activity
higher
safety.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(6), С. 4017 - 4023
Опубликована: Март 2, 2023
A
facile
cascade
reaction
for
the
site
selective
synthesis
of
2-cyanochromones
is
described.
By
using
simple
o-hydroxyphenyl
enaminones
and
potassium
ferrocyanide
trihydrate
(K4[Fe(CN)6]3·3H2O)
as
starting
materials
I2/AlCl3
promoters,
products
are
furnished
via
tandem
chromone
ring
formation
C–H
cyanation.
The
in
situ
3-iodochromone
a
formal
1,2-hydrogen
atom
transfer
(HAT)
process
account
unconventional
selectivity.
In
addition,
2-cyanoquinolin-4-one
has
been
realized
by
employing
corresponding
2-aminophenyl
enaminone
substrate.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(28)
Опубликована: Фев. 24, 2023
Using
benzylamines
as
the
C4
source
of
1,4-dihydropyridines
(1,4-DHPs),
a
Cu-catalyzed
oxidative
[1+2+1+2]
cascade
cyclization
for
synthesis
1,4-DHPs
was
firstly
developed.
A
broad
range
easily
available
N,N-dimethyl
enaminones
and
are
employed
smoothly
to
provide
diverse
with
high
efficiency.
This
method
is
performed
by
one-pot
C(sp3
)-H
bond
functionalization/C(sp3
)-N
cleavage/cyclization
strategy
form
simultaneously
two
)-C(sp2
)
bonds,
C(sp2
1,4-DHP
ring.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4843 - 4847
Опубликована: Янв. 1, 2023
An
unprecedented
dual
α,β-C(sp
2
)–H
functionalization/bicyclization
strategy
of
o
-hydroxyphenyl
enaminones
for
the
preparation
chromeno[2,3-
b
]pyrrol-4(1
H
)-ones
has
been
established.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(20), С. 5198 - 5204
Опубликована: Янв. 1, 2023
An
unprecedented
electrochemically
regioselective
C–H
phosphorothiolation
and
S-
to
C-[1,4]
phosphonyl
migration
involving
indolizines,
elemental
sulfur,
H-phosphonates
in
an
undivided
cell
has
been
developed.
