Three‐Component Reactions of Quinoxalin‐2(1H)‐ones: Recent Advances
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 11, 2023
Abstract
The
multicomponent
reactions
of
quinoxalin‐2(1
H
)‐ones
has
attracted
considerable
interest
due
to
their
significant
biological
and
chemical
activities.
very
recent
advances
(from
2021
the
beginning
2023)
on
radical
three‐component
cascade
reaction
)‐one
derivatives
at
C3
position
were
summarized
in
this
mini‐review.
According
kind
types
involved,
some
representative
examples
detailed
mechanism
have
been
categorized
discussed.
red
front
was
covered
by
Figure
1.
Язык: Английский
Sono-photocatalytic amination of quinoxalin-2(1H)-ones with aliphatic amines
Chinese Chemical Letters,
Год журнала:
2024,
Номер
35(10), С. 110038 - 110038
Опубликована: Май 22, 2024
Язык: Английский
Photoredox-Catalyzed Three-Component Amidoheteroarylation of Unactivated Alkenes
Organic Letters,
Год журнала:
2023,
Номер
25(22), С. 4113 - 4118
Опубликована: Май 30, 2023
A
photoredox-catalyzed
1,2-amidoheteroarylation
of
unactivated
alkenes
with
O-acyl
hydroxylamine
derivatives
and
heterocycles
is
presented.
range
heterocycles,
including
quinoxaline-2(1H)-ones,
azauracils,
chromones,
quinolones,
are
capable
for
this
process,
allowing
the
direct
synthesis
valuable
heteroarylethylamine
derivatives.
Structurally
diverse
reaction
substrates,
drug-based
scaffolds,
were
successfully
applied,
demonstrating
practicality
method.
Язык: Английский
Visible-Light-Promoted Deoxygenative Alkylation of Quinoxalin-2(1H)-ones with Activated Alcohols
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(9), С. 6334 - 6344
Опубликована: Апрель 15, 2024
A
one-pot
strategy
for
deoxygenative
alkylation
of
alcohols
with
quinoxalin-2(1H)-ones
was
developed
by
using
xanthate
salts
as
alcohol-activating
groups
radical
generation
in
the
presence
tricyclohexylphosphine
under
visible-light-promoted
conditions.
The
remarkable
features
this
reaction
include
a
broad
substrate
scope,
excellent
functional
group
tolerance,
mild
conditions,
and
simple
operation.
Moreover,
synthetic
utility
validated
success
two-step
reactions,
scale-up
synthesis,
chemoselective
monodeoxygenation
diols.
Язык: Английский
Visible‐Light‐Induced Metal‐Free Three‐Component Amidoheteroarylation of Alkenes to Synthesize β‐(Hetero)arylethylamines
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(19)
Опубликована: Март 21, 2024
Abstract
Herein,
visible‐light‐induced
metal‐free
three‐component
amidoheteroarylation
of
alkenes
with
quinoxalin‐2(1
H
)‐ones
and
N‐sulfonylaminopyridinium
salts
is
developed.
This
protocol
involves
a
radical
relay
process
in
which
the
N‐centered
radicals
undergo
chemoselective
addition
to
form
an
alkyl
that
selectively
combines
heteroarenes,
leading
formation
C−C
C−N
bonds
one
step
under
mild
reaction
conditions.
The
involved
high
efficiency
selectivity,
wide
substrate
scope,
excellent
functional‐group
compatibility
demonstrate
practicability
developed
protocol.
Язык: Английский
Photocatalytic Three‐Component α‐Trifluoroalkyl‐β‐heteroarylation of Unactivated Alkenes with Trifluoroacetates
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(27)
Опубликована: Май 23, 2024
Abstract
We
herein
disclose
a
direct
and
practical
photocatalytic
three‐component
α‐trifluoroalkyl‐β‐heteroarylation
of
various
unactivated
alkenes
with
trifluoroacetates
quinoxalin‐2(1
H
)‐ones.
The
reaction
takes
place
via
photoinduced
LMCT
process,
allowing
efficient
synthesis
variety
3‐fluoroalkylated
)‐one
derivatives
in
moderate
to
excellent
yields
under
mild
conditions.
Язык: Английский
Photoinduced Deaminative Alkylation of Quinoxalin‐2(1H)‐ones via an Electron Donor‐Acceptor Complex
ChemistrySelect,
Год журнала:
2023,
Номер
8(25)
Опубликована: Июль 3, 2023
Abstract
Formation
of
C−C
bonds
by
cleavage
the
C(sp
3
)−N
readily
available
alkyl
amines
is
a
valuable
transformation.
Herein,
we
report
method
for
oxidant‐
and
metal‐free
photoinduced
deaminative
alkylation
quinoxalin‐2(1
H
)‐ones
with
Katritzky
salts
as
radical
sources.
Various
radicals
could
easily
be
generated
single‐electron
reduction
electron
donor–acceptor
complexes
between
sodium
acetate.
This
green,
sustainable,
operationally
simple
has
broad
substrate
scope,
can
used
gram‐scale
synthesis,
late‐stage
modification
pharmaceutically
relevant
molecules.
Язык: Английский