Palladium‐Catalyzed Carbonylation of ortho‐Alkenyl Iodobenzenes for the Construction of 3‐Arylindenones
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Comprehensive
Summary
We
developed
a
novel
Pd‐catalyzed
carbonylation
of
ortho
‐alkenyl
iodobenzenes
with
CO,
affording
diverse
array
3‐arylindenones
in
good
to
excellent
yields
(up
94%
yield).
This
methodology
exhibits
broad
substrate
scope
and
functional
group
compatibility.
The
synthetic
utility
was
demonstrated
by
gram‐scale
reaction,
product
derivatizations,
the
preparation
an
intermediate
for
PPARγ
agonist.
Язык: Английский
Seven-membered ring systems
Progress in heterocyclic chemistry,
Год журнала:
2024,
Номер
unknown, С. 485 - 496
Опубликована: Янв. 1, 2024
Palladium(0)-Catalyzed Regioselective Three-Component Cross-Coupling via C–H Activation: Synthesis of Eight-Membered Azacycles
Qiongqiong Zhu,
Xiang Zuo,
Cang Cheng
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
A
Pd(0)-catalyzed
three-component
cross-coupling
reaction
involving
o-bromobenzylamines,
aryl
iodides,
and
alkynes
was
developed
through
C–H
activation.
This
exhibits
excellent
regioselectivity,
selectively
forming
a
C(vinyl)–C(aryl)
bond.
The
process
yields
eight-membered
azacycles
as
the
products,
providing
straightforward
access
to
such
compounds
using
simple
substrates.
Язык: Английский