Palladium‐Catalyzed Carbonylation of ortho‐Alkenyl Iodobenzenes for the Construction of 3‐Arylindenones

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Comprehensive Summary We developed a novel Pd‐catalyzed carbonylation of ortho ‐alkenyl iodobenzenes with CO, affording diverse array 3‐arylindenones in good to excellent yields (up 94% yield). This methodology exhibits broad substrate scope and functional group compatibility. The synthetic utility was demonstrated by gram‐scale reaction, product derivatizations, the preparation an intermediate for PPARγ agonist.

Language: Английский

Seven-membered ring systems

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 485 - 496

Published: Jan. 1, 2024

Palladium(0)-Catalyzed Regioselective Three-Component Cross-Coupling via C–H Activation: Synthesis of Eight-Membered Azacycles

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

A Pd(0)-catalyzed three-component cross-coupling reaction involving o-bromobenzylamines, aryl iodides, and alkynes was developed through C–H activation. This exhibits excellent regioselectivity, selectively forming a C(vinyl)–C(aryl) bond. The process yields eight-membered azacycles as the products, providing straightforward access to such compounds using simple substrates.

Language: Английский