Five-membered ring systems: Pyrroles and benzo analogs DOI
Chuan Shan, Justin M. Lopchuk

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173

Опубликована: Янв. 1, 2024

Язык: Английский

Review of application of the I2 and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations DOI
Dongsheng Yang, Xiang‐Long Chen, An‐Xin Wu

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(9), С. 2665 - 2692

Опубликована: Янв. 1, 2024

The synthesis of small molecules and complex scaffolds is one the most important topics in organic synthesis.

Язык: Английский

Процитировано

19
Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone DOI Open Access
Swadhin Swaraj Acharya,

Dibyaranjan Samantaray,

Chipuru Sibakrishna

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 1, 2025

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

Язык: Английский

Процитировано

1
Research progress of self-organized reaction networks for cascade reactions DOI

Yong‐Xing Tang,

An‐Xin Wu

Tetrahedron, Год журнала: 2024, Номер 166, С. 134210 - 134210

Опубликована: Авг. 27, 2024

Язык: Английский

Процитировано

4
Tandem Synthesis of Polysubstituted Pyrroles via Cu(I)-Catalyzed Cyclization of Ketene N,S-Acetals with β-Ketodinitriles DOI
Anup Sharma,

Mahesh Kumar,

Shiv Chand

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

A new approach to multifunctionalized pyrroles has been explored by the tandem cyclization of α-oxoketene-N,S-acetals with β-ketodinitriles using Cu(MeCN)4BF4 and Ag2CO3 in toluene under reflux conditions. The reaction involves C–C/C–N bond creation, is assumed proceed via enamine formation, intramolecular cyclization, rearrangement. potential methodology also demonstrated for a gram-scale as well some useful organic transformations. offers practical pathway achieve polysubstituted broad substrate scope good functional group tolerance.

Язык: Английский

Процитировано

0
Production of polysubstituted pyrroles from lignin β-O-4 models via a one-pot multicomponent reaction DOI
Qiang Qian, Yangming Ding, Qi Luo

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142283 - 142283

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Lithium Bromide-Promoted Formal C(sp3)–H Bond Insertion Reactions of β-Carbonyl Esters with Sulfoxonium Ylides to Synthesize 1,4-Dicarbonyl Compounds DOI

Hailin Guo,

Yuhao Ding,

Jingwen Fan

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(10), С. 6974 - 6986

Опубликована: Май 4, 2024

A LiBr-promoted formal C(sp3)–H bond insertion reaction between β-carbonyl esters and sulfoxonium ylides is established. This practical has a wide range of substrate scope for both to give variety 1,4-dicarbonyl compounds with 43–94% yields. The features transition-metal-free conditions exclusive C-alkylation chemselectivity. use bench-stable overcomes previous methods that require transition metal as catalysts unstable diazo or toxic haloketones alkylation reagents.

Язык: Английский

Процитировано

2
One‐Pot Synthesis of 3‐Hydroxy‐1H‐Pyrrolo[3,4‐b]quinolin‐1‐one via Enaminamides DOI

Xi Shen,

Zhi‐Cheng Yu,

You Zhou

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(21), С. 4399 - 4403

Опубликована: Июль 16, 2024

Abstract A multicomponent cascade cyclization reaction using aryl methyl ketones, amines, and enaminamide reagents to construct 3‐hydroxy‐1 H ‐pyrrolo[3,4‐ b ]quinolin‐1‐one skeleton with good substrate compatibility (50 examples) has been reported. The one‐pot, metal‐free process formed two C−C bonds, C−N a tetrasubstituted carbon stereocenter containing hydroxyl group. enabled modified transformation of drug molecules derivatization products.

Язык: Английский

Процитировано

0
Cascade [3 + 2] Annulation of 1,3-Dicarbonyl Compounds and Ethyl Secondary Amines for Pyrrole Synthesis via Poly C(sp3)–H Bond Functionalization DOI
Xiuli Li, Yunyun Liu, Jie‐Ping Wan

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 16049 - 16054

Опубликована: Окт. 21, 2024

The synthesis of polyfunctionalized pyrroles via the cascade reactions 1,3-dicarbonyl compounds and two molecules ethyl secondary amines has been realized simple iodine catalysis in presence Dess-Martin periodinane (DMP). formation target pyrrole products involves one new C-C C-N bonds major functionalization six C(sp

Язык: Английский

Процитировано

0
DABCO‐Mediated [4+1] Annulation of Cyclopropane‐1,1‐dicarbonitriles with Ethyl Glycinate to Access Ethyl (2‐Amino‐1H‐pyrrol‐1‐yl)acetates DOI

Wenzhe Cheng,

Yuhang Xue,

Cunde Wang

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(40)

Опубликована: Окт. 1, 2024

Abstract An effective DABCO‐promoted (4+1) annulation reaction for the synthesis of ethyl (2‐amino‐1H‐pyrrol‐1‐yl)acetate derivatives from 2‐aroyl‐3‐arylcyclopropane‐1,1‐dicarbonitriles and glycinate was developed. This strategy is characterized by readily accessible starting materials, mild conditions, simplicity operation.

Язык: Английский

Процитировано

0
Five-membered ring systems: Pyrroles and benzo analogs DOI
Chuan Shan, Justin M. Lopchuk

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0