Five-membered ring systems: Pyrroles and benzo analogs DOI
Chuan Shan, Justin M. Lopchuk

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 173

Published: Jan. 1, 2024

Language: Английский

Review of application of the I2 and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations DOI
Dongsheng Yang, Xiang‐Long Chen, An‐Xin Wu

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(9), P. 2665 - 2692

Published: Jan. 1, 2024

The synthesis of small molecules and complex scaffolds is one the most important topics in organic synthesis.

Language: Английский

Citations

16
Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone DOI Open Access
Swadhin Swaraj Acharya,

Dibyaranjan Samantaray,

Chipuru Sibakrishna

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

Language: Английский

Citations

1
Tandem Synthesis of Polysubstituted Pyrroles via Cu(I)-Catalyzed Cyclization of Ketene N,S-Acetals with β-Ketodinitriles DOI
Anup Sharma,

Mahesh Kumar,

Shiv Chand

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

A new approach to multifunctionalized pyrroles has been explored by the tandem cyclization of α-oxoketene-N,S-acetals with β-ketodinitriles using Cu(MeCN)4BF4 and Ag2CO3 in toluene under reflux conditions. The reaction involves C–C/C–N bond creation, is assumed proceed via enamine formation, intramolecular cyclization, rearrangement. potential methodology also demonstrated for a gram-scale as well some useful organic transformations. offers practical pathway achieve polysubstituted broad substrate scope good functional group tolerance.

Language: Английский

Citations

0
Production of polysubstituted pyrroles from lignin β-O-4 models via a one-pot multicomponent reaction DOI
Qiang Qian, Yangming Ding, Qi Luo

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142283 - 142283

Published: March 1, 2025

Language: Английский

Citations

0
Research progress of self-organized reaction networks for cascade reactions DOI

Yong‐Xing Tang,

An‐Xin Wu

Tetrahedron, Journal Year: 2024, Volume and Issue: 166, P. 134210 - 134210

Published: Aug. 27, 2024

Language: Английский

Citations

3
Lithium Bromide-Promoted Formal C(sp3)–H Bond Insertion Reactions of β-Carbonyl Esters with Sulfoxonium Ylides to Synthesize 1,4-Dicarbonyl Compounds DOI

Hailin Guo,

Yuhao Ding,

Jing-Wen Fan

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(10), P. 6974 - 6986

Published: May 4, 2024

A LiBr-promoted formal C(sp3)–H bond insertion reaction between β-carbonyl esters and sulfoxonium ylides is established. This practical has a wide range of substrate scope for both to give variety 1,4-dicarbonyl compounds with 43–94% yields. The features transition-metal-free conditions exclusive C-alkylation chemselectivity. use bench-stable overcomes previous methods that require transition metal as catalysts unstable diazo or toxic haloketones alkylation reagents.

Language: Английский

Citations

2
One‐Pot Synthesis of 3‐Hydroxy‐1H‐Pyrrolo[3,4‐b]quinolin‐1‐one via Enaminamides DOI

Xi Shen,

Zhi‐Cheng Yu,

You Zhou

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(21), P. 4399 - 4403

Published: July 16, 2024

Abstract A multicomponent cascade cyclization reaction using aryl methyl ketones, amines, and enaminamide reagents to construct 3‐hydroxy‐1 H ‐pyrrolo[3,4‐ b ]quinolin‐1‐one skeleton with good substrate compatibility (50 examples) has been reported. The one‐pot, metal‐free process formed two C−C bonds, C−N a tetrasubstituted carbon stereocenter containing hydroxyl group. enabled modified transformation of drug molecules derivatization products.

Language: Английский

Citations

0
Cascade [3 + 2] Annulation of 1,3-Dicarbonyl Compounds and Ethyl Secondary Amines for Pyrrole Synthesis via Poly C(sp3)–H Bond Functionalization DOI
Xiuli Li, Yunyun Liu, Jie‐Ping Wan

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 16049 - 16054

Published: Oct. 21, 2024

The synthesis of polyfunctionalized pyrroles via the cascade reactions 1,3-dicarbonyl compounds and two molecules ethyl secondary amines has been realized simple iodine catalysis in presence Dess-Martin periodinane (DMP). formation target pyrrole products involves one new C-C C-N bonds major functionalization six C(sp

Language: Английский

Citations

0
DABCO‐Mediated [4+1] Annulation of Cyclopropane‐1,1‐dicarbonitriles with Ethyl Glycinate to Access Ethyl (2‐Amino‐1H‐pyrrol‐1‐yl)acetates DOI

Wenzhe Cheng,

Yuhang Xue,

Cunde Wang

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(40)

Published: Oct. 1, 2024

Abstract An effective DABCO‐promoted (4+1) annulation reaction for the synthesis of ethyl (2‐amino‐1H‐pyrrol‐1‐yl)acetate derivatives from 2‐aroyl‐3‐arylcyclopropane‐1,1‐dicarbonitriles and glycinate was developed. This strategy is characterized by readily accessible starting materials, mild conditions, simplicity operation.

Language: Английский

Citations

0
Five-membered ring systems: Pyrroles and benzo analogs DOI
Chuan Shan, Justin M. Lopchuk

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 173

Published: Jan. 1, 2024

Language: Английский

Citations

0