Journal of Flow Chemistry,
Год журнала:
2023,
Номер
14(1), С. 149 - 159
Опубликована: Дек. 15, 2023
Abstract
In
this
paper
we
report
a
[2
+
2]
cycloaddition
reaction
between
ketenes
and
benzils,
characterized
by
an
unusual
double
photochemical
activation
triggered
visible
light.
Employment
of
flow
system
optimization
conditions
through
Design
Experiments
resulted
in
moderate
to
good
yields
the
corresponding
β-lactones.
A
thorough
computational
analysis
allowed
elucidate
mechanism
justify
observed
diastereoselectivity.
The
was
also
successfully
tested
with
mixed
showing
complete
regioselectivity.
Graphical
abstract
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(10), С. 4926 - 4975
Опубликована: Янв. 1, 2024
In
search
for
the
perfect
wave(length).
This
review
is
dedicated
to
recent
efforts
in
development
of
visible
light
driven
photochemical
strategies
occurring
coloured
organic
compounds.
Green Chemistry,
Год журнала:
2024,
Номер
26(5), С. 2705 - 2711
Опубликована: Янв. 1, 2024
A
novel
synthetic
strategy
to
access
strained
heterocycles
is
revealed
through
photocatalysed
annulative
formal
4-
endo-dig
cyclization
of
propargyl
alcohols/amines
with
benzoquinones
under
catalyst/reagent-free
conditions
using
non-hazardous
solvent.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
366(2), С. 168 - 182
Опубликована: Дек. 16, 2023
Abstract
Photoinduced
chemical
transformations
have
become
a
promising
aspect
of
organic
synthesis.
This
review
focuses
on
the
recent
advancements
in
harnessing
photoinduced
processes
for
formation
carbon‐chalcogen
(C−O,
C−S,
C−Se,
and
C−Te)
bonds
under
catalyst‐free
conditions.
These
pathways
typically
involve
either
radical
mechanism
or
creation
electron‐donor‐acceptor
(EDA)
complexes.
The
explores
intricacies
underlying
mechanisms,
discusses
limitations,
evaluates
applicability
various
methodologies
this
field.
Notably,
photocatalyst
transition
metal‐free
photochemical
reactions
offer
effective
alternatives
to
enhance
sustainability
research
area.
Synthesis,
Год журнала:
2024,
Номер
56(16), С. 2565 - 2571
Опубликована: Апрель 26, 2024
Abstract
Visible-light
photocatalytic
reactions
between
enaminones
and
thioureas
leading
to
thiazole
products
have
been
achieved.
The
annulation
process
consists
of
tandem
C–S
C–N
bond
formation
by
running
under
air
atmosphere
at
ambient
temperature.
Broad
substrate
tolerance
the
sustainable
protocol
has
verified
practical
synthesis
divergent
thiazoles
with
both
monocyclic
fused
cyclic
structures.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(5), С. 1070 - 1077
Опубликована: Янв. 15, 2024
Abstract
Thanks
to
an
unprecedented
gem
‐dialkyl
substituent
effect,
efficient
synthesis
of
tetrahydro
oxepine
derivatives
is
achieved
by
ring
expansion
vinyl
oxetanes
using
acceptor(−acceptor)
diazo
reagents
under
Cu(II)‐catalysis.
A
large
scope
2‐vinyl
and
either
mono
or
diester
give
access
a
series
functionalized
oxepines.
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(14)
Опубликована: Май 8, 2024
The
beginning
of
photochemical
reactions
revolutionized
synthetic
chemistry
through
sustainable
practices.
This
review
explores
cutting-edge
developments
in
leveraging
light-induced
processes
for
generating
cascaded
C-C
and
C-hetero
bonds
without
catalysts.
Significantly,
catalyst-free
photoinduced
methodologies
have
garnered
considerable
attention,
especially
the
creation
varied
heterocyclic
frameworks
drug
design
synthesis
natural
products.
article
delves
into
underlying
mechanisms,
addresses
limitations,
evaluates
various
methodologies,
emphasizing
potential
photocatalyst
transition
metal-free
to
enhance
sustainability.
Divided
two
sections,
it
covers
recent
strides
C-heteroatom
multiple
bond
formation
reactions.
A
visible
light-enabled
three-component
cascade
assembles
pyrrolopyrazoles
from
arylalkynes,
benzoquinones,
and
5-aminopyrazole
through
a
mechanistically
validated
carbonyl-alkyne
metathesis/(3
+
2)-cycloaddition/1,2-aryl
migration
sequence.
This
protocol
delivers
pyrrolopyrazole
heterocycles
in
up
to
96%
yield
with
excellent
functional
group
tolerance.
Preliminary
biological
screening
identified
promising
antitumor
activity
selected
products,
highlighting
the
potential
value
of
this
method.
The
proposed
reaction
mechanism
is
supported
by
control
experiments.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Abstract
The
rapid
assembly
of
diverse
cyclic
amines
from
simple
precursors
is
now
considered
as
an
ideal
platform
with
respect
to
efficiency
and
sustainability.
To
date,
numerous
synthetic
methods
have
been
successfully
developed
however,
most
them
are
limited
a
narrow
subset
amines,
variations
in
ring
size
often
requiring
different
substrates
distinct
strategies.
Furthermore,
the
“escape‐from‐Flatland”
concept
has
led
chemists
focus
on
synthesis
C(sp
3
)‐rich
small
molecules
for
potential
drug
candidates.
Herein,
successful
realization
radical‐polar
crossover
bicyclization
reaction
reported
easily
available
cyclopropylamines
substituted
alkenes
through
photoredox
catalysis.
This
approach
introduces
innovative
methodology
de
novo
collection
4/5‐,
5/5‐,
6/5‐,7/5‐,
5/6‐fused
saturated
bicyclic
systematic
modular
manner
excellent
diastereoselectivity.
work
highlights
utility
photoinduced
radical–polar
bicyclization,
applicability
which
showcased
by
functional
group
tolerance,
wide
substrate
scopes,
derivatization
reactions.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(43)
Опубликована: Май 29, 2024
Visible-light-mediated
[2+2]
photocycloaddition
reaction
can
be
considered
an
ideal
solution
due
to
its
green
and
sustainable
properties,
is
one
of
the
most
efficient
methods
synthesize
four-membered
ring
motifs.
Although
research
on
alkynes
challenging
because
diminished
reactivity
alkynes,
more
significant
strain
products,
remarkable
achievements
have
been
made
in
this
field.
In
article,
we
highlight
recent
advances
visible-light-mediated
reactions
with
focus
mechanism
late-stage
synthetic
applications.
Advances
obtaining
cyclobutenes,
azetines,
oxetene
active
intermediates
continue
breakthroughs
fascinating
field
research.
