An organocatalytic domino annulation approach via C(sp2)–OMe cleavage to unlock the synthesis of pyranochromenones enabled by HFIP
Chemical Communications,
Год журнала:
2024,
Номер
60(56), С. 7200 - 7203
Опубликована: Янв. 1, 2024
Fused
pyranochromenone
derivatives
have
extensive
applications
in
medicinal
chemistry.
Язык: Английский
Lewis acid‐promoted C–H Chalcogenation of Arenes and Heteroarenes
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
Abstract
An
efficient
catalytic
system
employing
TMS•OTf
for
the
regioselective
thiolation
of
electron‐rich
arenes
with
sulfonyl
hydrazides
has
been
developed.
The
reaction
occurs
in
a
solvent
mixture
dichloroethane
and
trifluoroethanol
under
mild
conditions,
addition
water.
This
method
furnishes
range
para
‐thio‐substituted
3‐sulfenyl‐indoles
good
to
excellent
yields,
marking
significant
advancement
organic
synthesis.
Язык: Английский
A Regioselective, One-Pot, Transition-Metal-Free α-Alkylation of Quinone Monoacetals for Various Organic Transformations
Organic Letters,
Год журнала:
2024,
Номер
26(45), С. 9682 - 9688
Опубликована: Ноя. 5, 2024
Regioselective
reactions
of
biologically
significant
quinones
are
challenging.
An
unprecedented
advancement
in
quinone
monoacetal
(QMA)
chemistry
is
proposed
for
constructing
regioselective
and
less
explored
α-alkylated
QMAs
through
the
Morita–Baylis–Hillman
(MBH)
reaction.
Electrophilic
were
transformed
to
nucleophilic
umpolung
reagents
aldol-type
condensation
with
several
electrophiles.
Mechanistic
studies
reveal
that
solvent
(TFE:water
(1:1))
situ-generated
potassium
acetate
accelerate
The
ensuing
MBH
adducts
scalable
underwent
post-synthetic
transformations
late-stage
functionalization.
Язык: Английский