Visible-Light-Mediated Three-Component Alkene 1,2-Alkylpyridylation Reaction Using Alkylboronic Acids as Radical Precursors for the Synthesis of 4-Alkylpyridines
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
We
report
the
photocatalyzed
three-component
alkene
1,2-alkylpyridylation
reaction
between
alkylboronic
acids,
4-cyanopyridine,
and
an
olefin
to
achieve
pyridination
alkylation
of
synthesis
structurally
diversified
4-alkylpyridines.
The
readily
available
easily
manipulated
acids
were
used
as
alkyl
radical
precursors.
reactions
take
place
under
mild
conditions
with
a
broad
substrate
scope
are
easy
scale
up
gram
level,
they
therefore
potential
practical
value
for
structural
modification
biologically
active
alkylpyridine
derivatives.
Язык: Английский
Sunlight-induced Three-Component Synthesis of α-Aminoketones: A Green and Sustainable Pathway Through EDA Complex
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
We
reported
a
sunlight-promoted,
three-component
reaction
involving
glyoxal
hydrates,
anilines,
and
4-alkyl
DHPs
for
the
synthesis
of
α-aminoketones
with
high
yields
under
ambient
conditions
without
additional
photocatalysts
or
additives.
Язык: Английский
Photoredox-Catalyzed Regioselective 1,3-Alkoxypyridylation of gem-Difluorocyclopropanes
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Difluoromethylene
and
pyridine
cores
are
very
important
structural
units
in
medicinal
chemistry.
Herein,
we
report
the
development
of
photoredox-catalyzed
ring-opening
1,3-alkoxypyridylation
gem-difluorinated
cyclopropanes
using
4-cyanopyrines
alcohols,
employing
cyclopropane
radical
cations
as
key
intermediate.
The
reaction
exhibits
high
regioselectivity
under
mild
conditions
can
also
be
practiced
on
gram-scale
synthesis,
telescoped
reaction,
late-stage
functionalization
biological
molecules.
Язык: Английский