Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Март 22, 2025
A mild and atom-economical reaction for the Sc(OTf)3-catalyzed 1,3-hydroxyheteroarylation of bicyclo[1.1.0]butanes (BCBs) with azaaryl N-oxides via an unprecedented [4π+2σ] cycloaddition/ring-opening process is described. This transformation provides a novel strategy highly regio- diastereoselective preparation azaheterocycle-tethered 1,1,3,3-tetrasubstituted cyclobutane derivatives offers broad substrate scope high yields.
Язык: Английский