Glutamine Antagonist Synergizes with Electrodynamic Therapy to Induce Tumor Regression and Systemic Antitumor Immunity DOI
Gui Chen, Qing Xu, Zhenzhen Feng

и другие.

ACS Nano, Год журнала: 2022, Номер 16(1), С. 951 - 962

Опубликована: Янв. 3, 2022

Electrodynamic therapy (EDT) combining nanotechnology with electronic current was used in this study to generate highly cytotoxic oxidative hydroxyl radicals (·OH) for tumor destruction. However, increasing evidence suggests that EDT treatment alone one time still faces great challenges achieving long-term suppression an immunosuppressive environment, which would raise the risk of later recurrence. Benefitting from marvelous potential reactive oxygen species (ROS)-mediated dynamic therapies immunocombination due their immunogenic cell death (ICD) effect, a glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON)-loaded nanocarrier (Pt-Pd@DON) designed combination (EDT and immunotherapy) against recurrence metastasis. The protective immune response motivated tumors by joint functions ICD CD8+ T infiltration promoted DON. A therapeutic efficacy has been demonstrated primary metastatic models, respectively. This provided effective thought way clinical treatment.

Язык: Английский

Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment DOI
Jiwoong Choi, In‐Cheol Sun,

Hee Sook Hwang

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 186, С. 114344 - 114344

Опубликована: Май 14, 2022

Язык: Английский

Процитировано

74

Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics DOI
Namrata Singh,

G. R. Sherin,

Govindasamy Mugesh

и другие.

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(33)

Опубликована: Апрель 21, 2023

Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.

Язык: Английский

Процитировано

63

Nanoceria: an innovative strategy for cancer treatment DOI Creative Commons
Joyce Tang, Shehzahdi S. Moonshi, Hang T. Ta

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2023, Номер 80(2)

Опубликована: Янв. 19, 2023

Abstract Nanoceria or cerium oxide nanoparticles characterised by the co-existing of Ce 3+ and 4+ that allows self-regenerative, redox-responsive dual-catalytic activities, have attracted interest as an innovative approach to treating cancer. Depending on surface characteristics immediate environment, nanoceria exerts either anti- pro-oxidative effects which regulate reactive oxygen species (ROS) levels in biological systems. mimics ROS-related enzymes protect normal cells at physiological pH from oxidative stress induce ROS production slightly acidic tumour microenvironment trigger cancer cell death. nanozymes also generates molecular relieves hypoxia, leading sensitisation improve therapeutic outcomes photodynamic (PDT), photothermal (PTT) radiation (RT), targeted chemotherapies. has been engineered a nanocarrier drug delivery combination with other drugs produce synergistic anti-cancer effects. Despite reported preclinical successes, there are still knowledge gaps arising inadequate number studies reporting findings based physiologically relevant disease models accurately represent complexities This review discusses activities responding tension gradient microenvironment, highlights recent nanoceria-based platforms be feasible direct indirect agents protective healthy tissues, finally addresses challenges clinical translation therapeutics.

Язык: Английский

Процитировано

53

Multifunctional nanoparticle for cancer therapy DOI Creative Commons
Yan Gao, Kaiyu Wang, Jin Zhang

и другие.

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Янв. 11, 2023

Cancer is a complex disease associated with combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment diagnosis for cancer, current strategies simultaneously focus on various tumor targets. Based the rapid development nanotechnology, nanocarriers have been shown to exhibit excellent potential cancer therapy. Compared nanoparticles single functions, multifunctional are believed be more aggressive potent context targeting. However, not simply an upgraded version original function, but involves sophisticated system proper backbone, optimized modification sites, simple preparation method, efficient function integration. Despite this, many well-designed promising therapeutic emerged recently. Here, give detailed understanding analyzation currently developed nanoparticles, their platform structures organic or inorganic backbones were systemically generalized. We emphasized functionalization strategies, which additional functions nanoparticle. also discussed application that involved nanoformulations functional crosstalk. This review thus provides overview construction advances nanoparticles.

Язык: Английский

Процитировано

48

Light‐Triggered Nitric Oxide Nanogenerator with Highl‐Arginine Loading for Synergistic Photodynamic/Gas/Photothermal Therapy DOI
Hui Shi,

Cheng‐Feng Xiong,

Lin‐Jun Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(20)

Опубликована: Март 17, 2023

The development of nanomedicines that combine photothermal therapy (PTT) with photodynamic (PDT) is considered promising for cancer treatment, but still faces the challenge enhancing tumoricidal efficiency. Fortunately, apart from well-acknowledged effect on direct tumor cell-killing, nitric oxide (NO) also to be effective enhancement both PTT and PDT. However, low loading efficiency NO precursor short half-life time diffusion distance hamper synergistic therapeutic efficacy NO. Taking aforementioned factors into account, a mitochondria-targeted nanogenerator, EArgFe@Ce6, constructed achieve high donor l-Arginine (l-Arg) photodynamic/gas/photothermal upon single 660 nm light irradiation. coordination epigallocatechin gallate (EGCG) ferric ions (Fe3+ ) provides EArgFe@Ce6 supreme capability perform low-temperature (mPTT). EGCG endows mitochondria-targeting meanwhile favors hypoxia alleviation enhanced PDT-produced massive reactive oxygen species (ROS) further catalyzes l-Arg generate considerable amount gas sensitize mPTT In vitro in vivo studies demonstrate triggered by irradiation highly treatments.

Язык: Английский

Процитировано

46

De Novo Designed Ru(II) Metallacycle as a Microenvironment‐Adaptive Sonosensitizer and Sonocatalyst for Multidrug‐Resistant Biofilms Eradication DOI
Yuling Xu,

Yida Pang,

Lishi Luo

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(15)

Опубликована: Фев. 8, 2024

Abstract Albeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and intricate biofilm microenvironment (BME), substantially hamper therapeutic efficacy against infections. To address bottlenecks, we innovatively design a Ru(II) metallacycle‐based sonosensitizer/sonocatalyst (named Ru‐A3‐TTD ) to enhance potency sonotherapy by employing molecular engineering strategies tailored BME. Our approach involves augmenting ’s production ultrasonic‐triggered reactive oxygen species (ROS), surpassing performance commercial sonosensitizers, through straightforward but potent π‐expansion approach. Within BME, synergistically amplifies sonotherapeutic via triple‐modulated approaches: (i) alleviation hypoxia, leading increased ROS generation, (ii) disruption antioxidant defense system, which shields from glutathione consumption, (iii) enhanced penetration, enabling deep sites. Notably, sono‐catalytically oxidizes NADPH, critical coenzyme involved defenses. Consequently, demonstrates superior eradication multidrug‐resistant Escherichia coli compared conventional clinical antibiotics, both vitro vivo. our knowledge, this study represents pioneering instance supramolecular sonosensitizer/sonocatalyst. It provides valuable insights into structure‐activity relationship paves promising pathway treatment

Язык: Английский

Процитировано

34

Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

и другие.

MedComm – Oncology, Год журнала: 2024, Номер 3(1)

Опубликована: Март 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Язык: Английский

Процитировано

32

Tumor microenvironment responsive nanozymes for multimodal imaging of tumors DOI Creative Commons
Heng Wang, Wenrui Ouyang, Hongxing Liu

и другие.

Nano TransMed, Год журнала: 2024, Номер 3, С. 100032 - 100032

Опубликована: Янв. 29, 2024

Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.

Язык: Английский

Процитировано

22

Nanomedicine: How nanomaterials are transforming drug delivery, bio-imaging, and diagnosis DOI Creative Commons
Fatma Kurul, Hasret Turkmen, Arif E. Çetin

и другие.

Next Nanotechnology, Год журнала: 2025, Номер 7, С. 100129 - 100129

Опубликована: Янв. 1, 2025

Процитировано

21

Platinum nanoparticles in cancer therapy: chemotherapeutic enhancement and ROS generation DOI

Emmanuel Faderin,

Terungwa H. Iorkula, Omowunmi Rebecca Aworinde

и другие.

Medical Oncology, Год журнала: 2025, Номер 42(2)

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

4