ACS Nano,
Год журнала:
2022,
Номер
16(1), С. 951 - 962
Опубликована: Янв. 3, 2022
Electrodynamic
therapy
(EDT)
combining
nanotechnology
with
electronic
current
was
used
in
this
study
to
generate
highly
cytotoxic
oxidative
hydroxyl
radicals
(·OH)
for
tumor
destruction.
However,
increasing
evidence
suggests
that
EDT
treatment
alone
one
time
still
faces
great
challenges
achieving
long-term
suppression
an
immunosuppressive
environment,
which
would
raise
the
risk
of
later
recurrence.
Benefitting
from
marvelous
potential
reactive
oxygen
species
(ROS)-mediated
dynamic
therapies
immunocombination
due
their
immunogenic
cell
death
(ICD)
effect,
a
glutamine
antagonist
6-diazo-5-oxo-l-norleucine
(DON)-loaded
nanocarrier
(Pt-Pd@DON)
designed
combination
(EDT
and
immunotherapy)
against
recurrence
metastasis.
The
protective
immune
response
motivated
tumors
by
joint
functions
ICD
CD8+
T
infiltration
promoted
DON.
A
therapeutic
efficacy
has
been
demonstrated
primary
metastatic
models,
respectively.
This
provided
effective
thought
way
clinical
treatment.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(33)
Опубликована: Апрель 21, 2023
Nanozymes,
nanomaterials
with
enzyme-mimicking
activity,
have
attracted
tremendous
interest
in
recent
years
owing
to
their
ability
replace
natural
enzymes
various
biomedical
applications,
such
as
biosensing,
therapeutics,
drug
delivery,
and
bioimaging.
In
particular,
the
nanozymes
capable
of
regulating
cellular
redox
status
by
mimicking
antioxidant
mammalian
cells
are
great
therapeutic
significance
oxidative-stress-mediated
disorders.
As
distinction
physiological
oxidative
stress
(oxidative
eustress)
pathological
distress)
occurs
at
a
fine
borderline,
it
is
challenge
design
that
can
differentially
sense
two
extremes
cells,
tissues
organs
mediate
appropriate
chemical
reactions.
this
Review,
we
summarize
advances
development
redox-active
applications.
We
primarily
highlight
prooxidant
disease
model
systems,
cancer,
neurodegeneration,
cardiovascular
diseases.
The
future
perspectives
emerging
area
research
challenges
associated
applications
described.
Cellular and Molecular Life Sciences,
Год журнала:
2023,
Номер
80(2)
Опубликована: Янв. 19, 2023
Abstract
Nanoceria
or
cerium
oxide
nanoparticles
characterised
by
the
co-existing
of
Ce
3+
and
4+
that
allows
self-regenerative,
redox-responsive
dual-catalytic
activities,
have
attracted
interest
as
an
innovative
approach
to
treating
cancer.
Depending
on
surface
characteristics
immediate
environment,
nanoceria
exerts
either
anti-
pro-oxidative
effects
which
regulate
reactive
oxygen
species
(ROS)
levels
in
biological
systems.
mimics
ROS-related
enzymes
protect
normal
cells
at
physiological
pH
from
oxidative
stress
induce
ROS
production
slightly
acidic
tumour
microenvironment
trigger
cancer
cell
death.
nanozymes
also
generates
molecular
relieves
hypoxia,
leading
sensitisation
improve
therapeutic
outcomes
photodynamic
(PDT),
photothermal
(PTT)
radiation
(RT),
targeted
chemotherapies.
has
been
engineered
a
nanocarrier
drug
delivery
combination
with
other
drugs
produce
synergistic
anti-cancer
effects.
Despite
reported
preclinical
successes,
there
are
still
knowledge
gaps
arising
inadequate
number
studies
reporting
findings
based
physiologically
relevant
disease
models
accurately
represent
complexities
This
review
discusses
activities
responding
tension
gradient
microenvironment,
highlights
recent
nanoceria-based
platforms
be
feasible
direct
indirect
agents
protective
healthy
tissues,
finally
addresses
challenges
clinical
translation
therapeutics.
Cancer
is
a
complex
disease
associated
with
combination
of
abnormal
physiological
process
and
exhibiting
dysfunctions
in
multiple
systems.
To
provide
effective
treatment
diagnosis
for
cancer,
current
strategies
simultaneously
focus
on
various
tumor
targets.
Based
the
rapid
development
nanotechnology,
nanocarriers
have
been
shown
to
exhibit
excellent
potential
cancer
therapy.
Compared
nanoparticles
single
functions,
multifunctional
are
believed
be
more
aggressive
potent
context
targeting.
However,
not
simply
an
upgraded
version
original
function,
but
involves
sophisticated
system
proper
backbone,
optimized
modification
sites,
simple
preparation
method,
efficient
function
integration.
Despite
this,
many
well-designed
promising
therapeutic
emerged
recently.
Here,
give
detailed
understanding
analyzation
currently
developed
nanoparticles,
their
platform
structures
organic
or
inorganic
backbones
were
systemically
generalized.
We
emphasized
functionalization
strategies,
which
additional
functions
nanoparticle.
also
discussed
application
that
involved
nanoformulations
functional
crosstalk.
This
review
thus
provides
overview
construction
advances
nanoparticles.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(20)
Опубликована: Март 17, 2023
The
development
of
nanomedicines
that
combine
photothermal
therapy
(PTT)
with
photodynamic
(PDT)
is
considered
promising
for
cancer
treatment,
but
still
faces
the
challenge
enhancing
tumoricidal
efficiency.
Fortunately,
apart
from
well-acknowledged
effect
on
direct
tumor
cell-killing,
nitric
oxide
(NO)
also
to
be
effective
enhancement
both
PTT
and
PDT.
However,
low
loading
efficiency
NO
precursor
short
half-life
time
diffusion
distance
hamper
synergistic
therapeutic
efficacy
NO.
Taking
aforementioned
factors
into
account,
a
mitochondria-targeted
nanogenerator,
EArgFe@Ce6,
constructed
achieve
high
donor
l-Arginine
(l-Arg)
photodynamic/gas/photothermal
upon
single
660
nm
light
irradiation.
coordination
epigallocatechin
gallate
(EGCG)
ferric
ions
(Fe3+
)
provides
EArgFe@Ce6
supreme
capability
perform
low-temperature
(mPTT).
EGCG
endows
mitochondria-targeting
meanwhile
favors
hypoxia
alleviation
enhanced
PDT-produced
massive
reactive
oxygen
species
(ROS)
further
catalyzes
l-Arg
generate
considerable
amount
gas
sensitize
mPTT
In
vitro
in
vivo
studies
demonstrate
triggered
by
irradiation
highly
treatments.
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100032 - 100032
Опубликована: Янв. 29, 2024
Nanozymes
exhibit
immense
potential
and
promising
prospects
in
the
realm
of
diagnostic
imaging
tumor
therapy,
owing
to
their
inherent
physicochemical
properties
enzymatic
activities.
With
further
development
application
nanotechnology,
nanozymes
are
expected
become
an
important
tool
field
medicine,
providing
new
solutions
for
disease
diagnosis
treatment.
This
review
provides
overview
recent
studies
over
past
five
years
on
capable
responding
microenvironment
(TME)
multimodal
imaging,
with
a
focus
hypoxia,
acid
pH,
excess
GSH
ROS.
In
addition,
we
present
current
status
several
common
related
contrast
agents,
such
as
MRI/CT,
MRI/PET,
MRI/SPECT,
PET/CT.
Moreover,
some
thoughts
challenges,
future
development,
clinical
translation
microenvironment-responsive
shared.
aims
provide
up-to-date
theranostic
nanomedicine
reference
those
who
fields,
promote
progress
this
interdisciplinary
subject,
accelerate
translation.
