Bioactive Materials,
Год журнала:
2022,
Номер
21, С. 381 - 393
Опубликована: Сен. 14, 2022
Acute
kidney
injury
(AKI)
can
lead
to
loss
of
function
and
a
substantial
increase
in
mortality.
The
burst
reactive
oxygen
species
(ROS)
plays
key
role
the
pathological
progression
AKI.
Mitochondrial-targeted
antioxidant
therapy
is
very
promising
because
mitochondria
are
main
source
ROS
Antioxidant
nanodrugs
with
actively
targeted
have
achieved
encouraging
success
many
oxidative
stress-induced
diseases.
However,
most
strategies
target
make
size
too
large
pass
through
glomerular
system
reach
renal
tubules,
damage
site
Here,
an
ultra-small
Tungsten-based
nanodots
(TWNDs)
strong
scavenging
be
effective
for
treatment
TWNDs
tubular
after
crossing
barrier,
enter
tubule
without
resorting
complex
active
targeting
strategies.
To
our
knowledge,
this
first
time
that
negatively
charged
used
passively
mitochondrial
Through
in-depth
study
therapeutic
mechanism,
such
passive
mitochondria-targeted
highly
protecting
by
reducing
increasing
mitophagy.
In
addition,
also
reduce
infiltration
inflammatory
cells.
This
work
provides
new
way
AKI,
give
inspiration
major
diseases
closely
related
mitochondria,
as
myocardial
infarction
cerebral
infarction.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 772 - 772
Опубликована: Фев. 26, 2023
Numerous
drugs
have
emerged
to
treat
various
diseases,
such
as
COVID-19,
cancer,
and
protect
human
health.
Approximately
40%
of
them
are
lipophilic
used
for
treating
diseases
through
delivery
routes,
including
skin
absorption,
oral
administration,
injection.
However,
a
low
solubility
in
the
body,
drug
systems
(DDSs)
being
actively
developed
increase
bioavailability.
Liposomes,
micro-sponges,
polymer-based
nanoparticles
been
proposed
DDS
carriers
drugs.
their
instability,
cytotoxicity,
lack
targeting
ability
limit
commercialization.
Lipid
(LNPs)
fewer
side
effects,
excellent
biocompatibility,
high
physical
stability.
LNPs
considered
efficient
vehicles
owing
lipid-based
internal
structure.
In
addition,
recent
LNP
studies
suggest
that
bioavailability
can
be
increased
surface
modifications,
PEGylation,
chitosan,
surfactant
protein
coating.
Thus,
combinations
an
abundant
utilization
potential
fields
DDSs
carrying
this
review,
functions
efficiencies
types
modifications
optimize
discussed.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 774 - 774
Опубликована: Фев. 26, 2023
Nanomedicine
is
a
branch
of
medicine
using
nanotechnology
to
prevent
and
treat
diseases.
Nanotechnology
represents
one
the
most
effective
approaches
in
elevating
drug‘s
treatment
efficacy
reducing
toxicity
by
improving
drug
solubility,
altering
biodistribution,
controlling
release.
The
development
materials
has
brought
profound
revolution
medicine,
significantly
affecting
various
major
diseases
such
as
cancer,
injection,
cardiovascular
experienced
explosive
growth
past
few
years.
Although
clinical
transition
nanomedicine
not
very
satisfactory,
traditional
drugs
still
occupy
dominant
position
formulation
development,
but
increasingly
active
have
adopted
nanoscale
forms
limit
side
effects
improve
efficacy.
review
summarized
approved
nanomedicine,
its
indications,
properties
commonly
used
nanocarriers
nanotechnology.
Nano Biomedicine and Engineering,
Год журнала:
2024,
Номер
16(2), С. 152 - 187
Опубликована: Фев. 5, 2024
In
recent
years,
the
deep
integration
of
basic
research
and
clinical
translational
nanotechnology
oncology
has
led
to
emergence
a
new
branch,
namely
integrated
nano-oncology.
This
is
an
emerging
important
interdisciplinary
field,
which
plays
irreplaceable
role
in
diagnosis,
treatment,
early
warning,
monitoring
prevention
tumors,
become
frontier.
Here
main
advances
nano-oncology
was
reviewed,
mainly
included
controlled
preparation
nanomaterials,
ultra-sensitive
detection
tumor
biomarkers,
multi-functional
nanoimaging
probes
diagnosis
treatment
technology,
innovative
nano
drugs
drug
delivery
system,
DNA
nanotechnology,
RNA
self-assembly
nanosensors,
intelligent
nanorobots,
nanotherapeutic
machines.
The
terms,
concepts,
trends
challenges
are
also
discussed
with
aim
promoting
application
solving
scientific
key
technical
problems
cancer.
Bioactive Materials,
Год журнала:
2023,
Номер
32, С. 445 - 472
Опубликована: Окт. 26, 2023
Effective
tumor
treatment
depends
on
optimizing
drug
penetration
and
accumulation
in
tissue
while
minimizing
systemic
toxicity.
Nanomedicine
has
emerged
as
a
key
solution
that
addresses
the
rapid
clearance
of
free
drugs,
but
achieving
deep
into
solid
tumors
remains
elusive.
This
review
discusses
various
strategies
to
enhance
penetration,
including
manipulation
microenvironment,
exploitation
both
external
internal
stimuli,
pioneering
nanocarrier
surface
engineering,
development
innovative
tactics
for
active
penetration.
One
outstanding
strategy
is
organelle-affinitive
transfer,
which
exploits
unique
properties
specific
cell
organelles
heralds
potentially
transformative
approach
transcellular
transfer
Rigorous
models
are
essential
evaluate
efficacy
these
strategies.
The
patient-derived
xenograft
(PDX)
model
gaining
traction
bridge
between
laboratory
discovery
clinical
application.
However,
journey
from
bench
bedside
nanomedicines
fraught
with
challenges.
Future
efforts
should
prioritize
deepening
our
understanding
nanoparticle-tumor
interactions,
re-evaluating
EPR
effect,
exploring
novel
nanoparticle
transport
mechanisms.
Sensors & Diagnostics,
Год журнала:
2024,
Номер
3(2), С. 203 - 217
Опубликована: Янв. 1, 2024
In
this
review,
we
provide
a
comprehensive
overview
of
the
latest
advancements
in
diagnostic
sensor
design
using
nIR
fluorescent
SWCNTs
and
suggest
potential
directions
for
technological
developments
real-world
applications.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Сен. 17, 2024
Nanocarriers
(NCs)
play
a
crucial
role
in
delivering
theranostic
agents
to
tumors,
making
them
pivotal
focus
of
research.
However,
the
persistently
low
delivery
efficiency
engineered
NCs
has
been
significant
challenge
advancement
nanomedicine,
stirring
considerable
debate.
Transvascular
transport
is
critical
pathway
for
NC
from
vessels
yet
comprehensive
understanding
interactions
between
and
vascular
systems
remains
elusive.
In
recent
years,
efforts
have
invested
elucidating
transvascular
mechanisms
NCs,
leading
promising
advancements
tumor
theranostics.
this
context,
we
highlight
various
mechanisms,
including
enhanced
permeability
retention
effect,
cooperative
immune-driven
active
transcytosis,
cell/bacteria-mediated
delivery.
Furthermore,
explore
corresponding
strategies
aimed
at
enhancing
efficient
These
approaches
offer
intriguing
solutions
spanning
physicochemical,
biological,
pharmacological
domains
improve
therapeutic
outcomes.
Additionally,
propose
forward-looking
framework
that
relies
on
advanced
tumor/vessel
models,
high-throughput
libraries,
nano-bio
interaction
datasets,
artificial
intelligence,
which
aims
guide
design
next-generation
carriers
implementation
optimized
Theranostics,
Год журнала:
2025,
Номер
15(5), С. 1689 - 1714
Опубликована: Янв. 2, 2025
In
recent
years,
nano-drug
delivery
systems
(Nano-DDS)
that
target
the
tumor
microenvironment
(TME)
to
overcome
multidrug
resistance
(MDR)
have
become
a
research
hotspot
in
field
of
cancer
therapy.
By
precisely
targeting
TME
and
regulating
its
unique
pathological
features,
such
as
hypoxia,
weakly
acidic
pH,
abnormally
expressed
proteins,
etc.,
these
Nano-DDS
enable
effective
therapeutic
agents
reversal
MDR.
This
scientific
community
is
increasing
investment
development
diversified
exploring
their
anti-drug
potential.
Therefore,
it
particularly
important
conduct
comprehensive
review
progress
TME-targeted
years.
After
brief
introduction
MDR,
design
principle
structure
liposomes,
polymer
micelles
inorganic
nanocarriers
are
focused
on,
characteristics
described.
It
also
demonstrates
how
break
through
MDR
treatment
various
mechanisms,
discusses
synthetic
innovation,
results
overcoming
mechanisms.
The
was
concluded
with
deliberations
on
key
challenges
future
outlooks
