Recent Progress of Lipid Nanoparticles-Based Lipophilic Drug Delivery: Focus on Surface Modifications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 772 - 772

Published: Feb. 26, 2023

Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and protect human health. Approximately 40% of them are lipophilic used for treating diseases through delivery routes, including skin absorption, oral administration, injection. However, a low solubility in the body, drug systems (DDSs) being actively developed increase bioavailability. Liposomes, micro-sponges, polymer-based nanoparticles been proposed DDS carriers drugs. their instability, cytotoxicity, lack targeting ability limit commercialization. Lipid (LNPs) fewer side effects, excellent biocompatibility, high physical stability. LNPs considered efficient vehicles owing lipid-based internal structure. In addition, recent LNP studies suggest that bioavailability can be increased surface modifications, PEGylation, chitosan, surfactant protein coating. Thus, combinations an abundant utilization potential fields DDSs carrying this review, functions efficiencies types modifications optimize discussed.

Language: Английский

---

Approved Nanomedicine against Diseases

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 774 - 774

Published: Feb. 26, 2023

Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one the most effective approaches in elevating drug‘s treatment efficacy reducing toxicity by improving drug solubility, altering biodistribution, controlling release. The development materials has brought profound revolution medicine, significantly affecting various major diseases such as cancer, injection, cardiovascular experienced explosive growth past few years. Although clinical transition nanomedicine not very satisfactory, traditional drugs still occupy dominant position formulation development, but increasingly active have adopted nanoscale forms limit side effects improve efficacy. review summarized approved nanomedicine, its indications, properties commonly used nanocarriers nanotechnology.

Language: Английский

---

Advances and Prospects in Integrated Nano-oncology

Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(2), P. 152 - 187

Published: Feb. 5, 2024

In recent years, the deep integration of basic research and clinical translational nanotechnology oncology has led to emergence a new branch, namely integrated nano-oncology. This is an emerging important interdisciplinary field, which plays irreplaceable role in diagnosis, treatment, early warning, monitoring prevention tumors, become frontier. Here main advances nano-oncology was reviewed, mainly included controlled preparation nanomaterials, ultra-sensitive detection tumor biomarkers, multi-functional nanoimaging probes diagnosis treatment technology, innovative nano drugs drug delivery system, DNA nanotechnology, RNA self-assembly nanosensors, intelligent nanorobots, nanotherapeutic machines. The terms, concepts, trends challenges are also discussed with aim promoting application solving scientific key technical problems cancer.

Language: Английский

---

A nIR fluorescent single walled carbon nanotube sensor for broad-spectrum diagnostics

Sensors & Diagnostics, Journal Year: 2024, Volume and Issue: 3(2), P. 203 - 217

Published: Jan. 1, 2024

In this review, we provide a comprehensive overview of the latest advancements in diagnostic sensor design using nIR fluorescent SWCNTs and suggest potential directions for technological developments real-world applications.

Language: Английский

---

Formulation of lactoferrin decorated dextran based chitosan-coated europium metal-organic framework for targeted delivery of curcumin

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129325 - 129325

Published: Jan. 13, 2024

Language: Английский

---

Intelligent micro/nanomotors: Fabrication, propulsion, and biomedical applications

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102212 - 102212

Published: Feb. 26, 2024

Language: Английский

---

Tunable rigidity of PLGA shell-lipid core nanoparticles for enhanced pulmonary siRNA delivery in 2D and 3D lung cancer cell models

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 746 - 760

Published: Jan. 20, 2024

Language: Английский

---

Tumor microenvironment targeted nano-drug delivery systems for multidrug resistant tumor therapy

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1689 - 1714

Published: Jan. 2, 2025

In recent years, nano-drug delivery systems (Nano-DDS) that target the tumor microenvironment (TME) to overcome multidrug resistance (MDR) have become a research hotspot in field of cancer therapy. By precisely targeting TME and regulating its unique pathological features, such as hypoxia, weakly acidic pH, abnormally expressed proteins, etc., these Nano-DDS enable effective therapeutic agents reversal MDR. This scientific community is increasing investment development diversified exploring their anti-drug potential. Therefore, it particularly important conduct comprehensive review progress TME-targeted years. After brief introduction MDR, design principle structure liposomes, polymer micelles inorganic nanocarriers are focused on, characteristics described. It also demonstrates how break through MDR treatment various mechanisms, discusses synthetic innovation, results overcoming mechanisms. The was concluded with deliberations on key challenges future outlooks

Language: Английский

---

An NIR Discrete Metallacycle Constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for Imaging‐Guided Cancer Radio‐Chemotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Nov. 25, 2021

To promote the clinical theranostic performances of platinum-based anticancer drugs, imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be upgraded. Herein, a metallacycle (M) developed for imaging-guided cancer radio-chemotherapy using perylene bisimide fluorophore (PPy) tetraphenylethylene-based di-Pt(II) organometallic precursor (TPE-Pt) as building blocks. The formation this discrete supramolecular coordination complex facilitates encapsulation M by glutathione (GSH)-responsive amphiphilic block copolymer prepare M-loaded nanoparticles (MNPs). TPE-Pt acts drug also an excellent radiosensitizer, thus incorporating radiotherapy into nanomedicine accelerate therapeutic overcome resistance. NIR-emission PPy employed detect intracellular delivery tissue distribution MNPs in real time. In vitro vivo investigations demonstrate combining chemotherapy radiotherapy; administration effectively inhibits tumor growth greatly extends survival rate cisplatin-resistant A2780CIS-tumor-bearing mice. Guided fluorescence imaging, precisely carried out, which boosting outcomes minimizing undesired side effects. success system brings new hope nanomedicines potential translations.

Language: Английский

---

Plasmon‐Driven Catalytic Chemotherapy Augments Cancer Immunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(34)

Published: July 18, 2021

Clinical trials confirm the combination of indoleamine 2,3-dioxygenase (IDO) blockade and immunogenic chemotherapy represents a brilliant future in cancer therapy. However, it remains challenging to precisely activate chemo-immunotherapy situ avoid side effects from systemic administrations reverse poor immunogenicity immunosuppressive microenvironment tumor sites. Herein, hybrid nanomedicine ("RPMANB NPs") co-deliver an IDO inhibitor (NLG919) chemotherapeutic prodrug amplify therapeutic benefits are designed. Attributed delicate surface engineering, RPMANB NPs possess excellent pharmacokinetics accumulation. The loaded NLG919 released inside tissues/cells due collapse metal-organic framework platform triggered by highly concentrated phosphate, reversing suppressing activity. potent drug is activated through efficient plasmon-driven catalysis presence near-infrared light, eliciting antitumor immunity triggering cell death avoiding activation chemotherapy. In vivo studies demonstrate that greatly suppresses growth promoting intratumoral accumulation cytotoxic T lymphocytes downregulating regulatory cells. This work establishes robust delivery overcome current obstacles treatments combining activatable with immunotherapy.

Language: Английский

---