European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 268, С. 116274 - 116274
Опубликована: Фев. 21, 2024
Язык: Английский
Advanced Science, Год журнала: 2021, Номер 8(15)
Опубликована: Май 26, 2021
The increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate preferred chemical scaffolds discovery antibacterial agents. Here, potential natural flavonoids from plants against MDR bacteria, is demonstrated. Structure-activity relationship analysis shows prenylation modulates activity obtains two compounds, α-mangostin (AMG) isobavachalcone (IBC). AMG IBC not only display rapid bactericidal Gram-positive but also restore susceptibility colistin Gram-negative pathogens. Mechanistic studies generally show such compounds bind to phospholipids membrane, result in dissipation proton motive force metabolic perturbations, through distinctive modes action. efficacy four models associated with infection or contamination, These results suggest that may be a promising underappreciated reservoir circumvent existing antibiotic resistance.
Язык: Английский
Процитировано
293
Molecules, Год журнала: 2022, Номер 27(4), С. 1149 - 1149
Опубликована: Фев. 9, 2022
According to the latest report released by World Health Organization, bacterial resistance well-known and widely available antibacterial drugs has become a significant severe global health concern grim challenge tackle in order cure infections associated with multidrug-resistant pathogenic microorganisms efficiently. Consequently, various strategies have been orchestrated complications related bacteria effectively. Some approaches involved retardation of biofilm formation multidrug-resistance pumps as well discovery new antimicrobial agents demonstrating different mechanisms action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, flavonoids, saponins, tannins, etc., suggested strains owing their versatile pharmacological effects. Amongst these, also known polyphenolic compounds, evaluated for property due tendency retard growth wide range microorganisms, including bacteria. The hydroxylation C5, C7, C3′, C4′; geranylation or prenylation at C6 extensively studied increase inhibition flavonoids. On other hand, methoxylation C3′ C5 reported decrease flavonoids’ Hence, information on activity flavonoids is summarized review, particular attention structure–activity relationship broad class compounds discover safe potent products.
Язык: Английский
Процитировано
293
Advanced Science, Год журнала: 2022, Номер 9(27)
Опубликована: Июль 25, 2022
Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.
Язык: Английский
Процитировано
180
Antioxidants, Год журнала: 2022, Номер 11(3), С. 459 - 459
Опубликована: Фев. 25, 2022
The rapid spread of antibiotic resistance and lack effective drugs for treating infections caused by multi-drug resistant bacteria in animal human medicine have forced us to find new antibacterial strategies. Natural products served as powerful therapeutics against bacterial infection are still an important source the discovery novel drugs. Curcumin, constituent turmeric, is considered safe oral consumption treat infections. Many studies showed that curcumin exhibited activities Gram-negative Gram-positive bacteria. action involves disruption membrane, inhibition production virulence factors biofilm formation, induction oxidative stress. These characteristics also contribute explain how acts a broad-spectrum adjuvant, which was evidenced markedly additive or synergistical effects with various types conventional antibiotics non-antibiotic compounds. In this review, we summarize properties, underlying molecular mechanism curcumin, discuss its combination use, nano-formulations, safety, current challenges towards development agent. We hope review provides valuable insight, stimulates broader discussions, spurs further developments around promising natural product.
Язык: Английский
Процитировано
168
Journal of Medicinal Chemistry, Год журнала: 2022, Номер 65(24), С. 16879 - 16892
Опубликована: Дек. 13, 2022
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) continue to endanger public health. Here, we report the synthesis of neolignan isomagnolone (I) and its isomer II, preparation a series novel neolignan-antimicrobial peptide (AMP) mimic conjugates. Notably, conjugates III5 III15 exhibit potent anti-MRSA activity in vitro vivo, comparable that vancomycin, current effective treatment for MRSA. Moreover, display not only fast-killing kinetics low resistance frequency but also toxicity as well effects on bacterial biofilms. Mechanism studies reveal rapid bactericidal through binding phosphatidylglycerol (PG) cardiolipin (CL) membrane, thereby disrupting cell membranes allowing increased reactive oxygen species (ROS) protein DNA leakage. The results indicate these neolignan-AMP could be promising antimicrobial candidates combating MRSA infections.
Язык: Английский
Процитировано
100
Trends in Microbiology, Год журнала: 2023, Номер 32(4), С. 365 - 378
Опубликована: Ноя. 25, 2023
Язык: Английский
Процитировано
68
Journal of Advanced Research, Год журнала: 2023, Номер 57, С. 197 - 212
Опубликована: Май 1, 2023
The continuous emergence and rapid spread of multidrug-resistant bacteria have accelerated the demand for discovery alternative antibiotics. Natural plants contain a variety antibacterial components, which is an important source antimicrobial agents. To explore activities related mechanisms two lavandulylated flavonoids, sophoraflavanone G kurarinone in Sophora flavescens against methicillin-resistant Staphylococcus aureus. effects on aureus were comprehensively investigated by combination proteomics metabolomics studies. Bacterial morphology was observed scanning electron microscopy. Membrane fluidity, membrane potential, integrity determined using fluorescent probes Laurdan, DiSC3(5), propidium iodide, respectively. Adenosine triphosphate reactive oxygen species levels adenosine kit kit, affinity activity to cell isothermal titration calorimetry assays. Sophoraflavanone showed significant anti-multidrug resistance properties. Mechanistic studies mainly that they could target bacterial cause destruction biosynthesis. They inhibit wall synthesis, induce hydrolysis prevent from synthesizing biofilms. In addition, can interfere with energy metabolism disrupt normal physiological bacteria. vivo shown significantly improve wound infection promote healing. Kurarinone promising properties aureus, suggesting may be potential candidates development new antibiotic agents
Язык: Английский
Процитировано
59
Science Advances, Год журнала: 2023, Номер 9(23)
Опубликована: Июнь 9, 2023
In the face of alarming rise in global antimicrobial resistance, only a handful novel antibiotics have been developed recent decades, necessitating innovations therapeutic strategies to fill void antibiotic discovery. Here, we established screening platform mimicking host milieu select adjuvants and found three catechol-type flavonoids—7,8-dihydroxyflavone, myricetin, luteolin—prominently potentiating efficacy colistin. Further mechanistic analysis demonstrated that these flavonoids are able disrupt bacterial iron homeostasis through converting ferric ferrous form. The excessive intracellular modulated membrane charge bacteria via interfering two-component system pmrA / pmrB , thereby promoting colistin binding subsequent damage. potentiation was further confirmed an vivo infection model. Collectively, current study provided as adjuvant replenish our arsenals for combating infections shed light on signaling promising target antibacterial therapies.
Язык: Английский
Процитировано
58
Medicinal Research Reviews, Год журнала: 2023, Номер 43(4), С. 1068 - 1090
Опубликована: Март 10, 2023
Novel antibacterial therapies are urgently required to tackle the increasing number of multidrug-resistant pathogens. Identification new antimicrobial targets is critical avoid possible cross-resistance issues. Bacterial proton motive force (PMF), an energetic pathway located on bacterial membrane, crucially regulates various biological possesses such as adenosine triphosphate synthesis, active transport molecules, and rotation flagella. Nevertheless, potential PMF target remains largely unexplored. The generally comprises electric (ΔΨ) transmembrane gradient (ΔpH). In this review, we present overview PMF, including its functions characterizations, highlighting representative agents that specifically either ΔΨ or ΔpH. At same time, also discuss adjuvant PMF-targeting compounds. Lastly, highlight value disruptors in preventing transmission antibiotic resistance genes. These findings suggest represents unprecedented target, providing a comprehensive approach controlling resistance.
Язык: Английский
Процитировано
49
Archives of Pharmacal Research, Год журнала: 2023, Номер 46(4), С. 207 - 272
Опубликована: Апрель 1, 2023
Язык: Английский
Процитировано
47