Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Год журнала: 2022, Номер 9(27)

Опубликована: Июль 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Язык: Английский

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Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Ноя. 24, 2023

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu

Язык: Английский

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On‐Demand Removable Self‐Healing and pH‐Responsive Europium‐Releasing Adhesive Dressing Enables Inflammatory Microenvironment Modulation and Angiogenesis for Diabetic Wound Healing

Small, Год журнала: 2022, Номер 19(3)

Опубликована: Ноя. 1, 2022

Abstract Current diabetic wound treatments remain unsatisfactory due to the lack of a comprehensive strategy that can integrate strong applicability (tissue adhesiveness, shape adaptability, fast self‐healability, and facile dressing change) with initiation smooth connection cascade healing processes. Herein, benefiting from multifaceted bonding ability tannic acid metal ions various polymers, family tannin–europium coordination complex crosslinked citrate‐based mussel‐inspired bioadhesives (TE‐CMBAs) are specially developed for healing. TE‐CMBAs gel instantly (< 60 s), possess favorable shape‐adaptability, considerable mechanical strengths, high elasticity, wet tissue adhesiveness (≈40 kPa), photothermal antimicrobial activity, excellent anti‐oxidant biocompatibility, angiogenetic property. The reversible hydrogen bond crosslinking sensitive metal–phenolic also confers pH‐responsive europium ion TA releasing properties on‐demand removability upon mixing borax solution, enabling convenient painless change inflammatory microenvironment modulation, angiogenesis promotion, effective extracellular matrix production leveraging acidic pH condition wounds. This adhesive provides regenerative management be extended other complicated scenarios.

Язык: Английский

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Dually Crosslinked Copper‐Poly(tannic acid) Nanoparticles with Microenvironment‐Responsiveness for Infected Wound Treatment

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(17)

Опубликована: Фев. 26, 2023

Abstract Reducing the burden of death due to wound infection is an urgent global public health priority. Metal‐phenolic networks (MPNs) have received widespread attention in antimicrobial infections their facile synthesis process, excellent biocompatibility, and properties brought about by polyphenols metal ions. However, typical therapeutic MPNs show rapid release ions poor solution stability, impeding long‐acting efficacy multiple healing stages. To address these issues, copper‐poly (tannic acid) nanoparticles (Cu‐PTA NPs): robust (dually crosslinked), microenvironment‐responsive, antibacterial, antioxidative, anti‐inflammatory are prepared, which hierarchically modulate infected process. Covalently polymerized via phenol‐formaldehyde condensation crosslinked with bioactive Cu 2+ , reactive preserved, efficiently entrapped PTA scaffold. The proposed strategy relieves systemic toxicity, only high oxygen species (ROS)level as stimuli can “turn on” catalytic activity implement antibacterial therapy specifically wound. Systematic tissue regeneration assessment on full‐thickness skin wounds rats demonstrates enhanced rate. Cu‐PTA NPs enables direct application exertion efficacy. This synergetic will pave way for more complicated inflammatory diseases.

Язык: Английский

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Injectable sodium alginate hydrogel loaded with plant polyphenol-functionalized silver nanoparticles for bacteria-infected wound healing

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 234, С. 123691 - 123691

Опубликована: Фев. 20, 2023

Язык: Английский

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Research progress of polyphenols in nanoformulations for antibacterial application

Materials Today Bio, Год журнала: 2023, Номер 21, С. 100729 - 100729

Опубликована: Июль 11, 2023

Infectious disease is one of the top 10 causes death worldwide, especially in low-income countries. The extensive use antibiotics has led to an increase antibiotic resistance, which poses a critical threat human health globally. Natural products such as polyphenolic compounds and their derivatives have been shown positive therapeutic effects antibacterial therapy. However, inherent physicochemical properties limit pharmaceutical effects, short half-lives, chemical instability, low bioavailability, poor water solubility. Nanoformulations promising advantages improving activity by controlling release drugs enhancing bioavailability polyphenols. In this review, we listed classification mechanisms compounds. More importantly, nanoformulations for delivery polyphenols agent were summarized, including different types nanoparticles (NPs) polymer-based NPs, metal-based lipid-based nanoscaffolds nanogels, nanofibers, nanoemulsions. At same time, also presented potential biological applications nano-system enhance ability polyphenols, aiming provide new perspective antibiotic-free treatment infectious diseases.

Язык: Английский

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Zinc‐Based Tannin‐Modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(20)

Опубликована: Март 25, 2023

Treatment of infected bone defects is a major clinical challenge; bioactive materials combining sufficient antimicrobial activity and favorable osteogenic ability are urgently needed. In this study, through facile one-pot hydrothermal reaction zinc acetate in the presence tannic acid (TA), with or without silver nitrate (AgNO3 ), used to synthesize TA nanoparticles (Ag NPs) bulk-modified oxide (ZnO) (ZnO-TA ZnO-TA-Ag), which further composited zein fabricate porous microparticulate scaffolds for defect repair. Bulk modification significantly improves release rate antibacterial metal ions (Zn2+ >100 times that ZnO). Fast long-lasting (>35 d) Zn2+ Ag+ guaranteed capability excellent properties promoting differentiation marrow mesenchymal stem cells endogenous citric production mineralization providing considerable immunomodulatory M2 polarization macrophages. At same time, synchronously-released could scavenge reactive oxygen species (ROS) ROS produced by ions, effectively balancing osteogenesis sufficiently control infection while protecting surrounding tissue from damage, thus

Язык: Английский

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Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Язык: Английский

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Multifunctional Dual Network Hydrogel Loaded with Novel Tea Polyphenol Magnesium Nanoparticles Accelerates Wound Repair of MRSA Infected Diabetes

Advanced Functional Materials, Год журнала: 2024, Номер 34(22)

Опубликована: Фев. 6, 2024

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infection, caused by impaired glucose metabolism in diabetic foot patients, poses a significant obstacle to the healing process and carries high risk of being life‐threatening. Due microvascular occlusion entrenchment MRSA biofilms foot, controlling effectively treating infection remains challenging. Traditional hydrogels suffer from swelling‐related mechanical issues inadequate drug release control, limiting their applications as biomimetic extracellular matrices for wound healing. Herein, double‐network hydrogel composed polyvinyl alcohol, sodium alginate, gelatin (PSG) loaded with tea polyphenol self‐assembled magnesium nanoparticles (TP‐Mg NPs) antibacterial angiogenic properties MRSA‐infected wounds under hyperglycemic conditions is constructed. TP‐Mg@PSG exhibits enhanced strength toughness attachment recovery movement torsion. In acidic microenvironment representative wounds, degrades TP‐Mg NPs, showing excellent anti‐MRSA effect biocompatibility. Such localized controlled enhances inhibition reduces inflammatory response rats, promoting cell proliferation rapid repair. Therefore, this study presents multifunctional biomaterial system managing conditions, highlighting its potential clinical applications.

Язык: Английский

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Nanoarchitectonics of in Situ Antibiotic-Releasing Acicular Nanozymes for Targeting and Inducing Cuproptosis-like Death to Eliminate Drug-Resistant Bacteria

ACS Nano, Год журнала: 2024, Номер 18(35), С. 24327 - 24349

Опубликована: Авг. 22, 2024

A series of progress has been made in the field antimicrobial use nanozymes due to their superior stability and decreased susceptibility drug resistance. However, catalytically generated reactive oxygen species (ROS) are insufficient for coping with multidrug-resistant organisms (MDROs) complex wound environments low targeting ability catalytic activity. To address this problem, chemically stable copper-gallic acid-vancomycin (CuGA-VAN) nanoneedles were successfully constructed by a simple approach bacteria; these exhibit OXD-like GSH-px-like dual enzyme activities produce ROS induce bacterial cuproptosis-like death, thereby eliminating MDRO infections. The results

Язык: Английский

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