Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1323 - 1323
Опубликована: Апрель 23, 2023
Metal–phenolic
networks
(MPNs)
are
a
new
type
of
nanomaterial
self-assembled
by
metal
ions
and
polyphenols
that
have
been
developed
rapidly
in
recent
decades.
They
widely
investigated,
the
biomedical
field,
for
their
environmental
friendliness,
high
quality,
good
bio-adhesiveness,
bio-compatibility,
playing
crucial
role
tumor
treatment.
As
most
common
subclass
MPNs
family,
Fe-based
frequently
used
chemodynamic
therapy
(CDT)
phototherapy
(PTT),
where
they
often
as
nanocoatings
to
encapsulate
drugs,
well
Fenton
reagents
photosensitizers
improve
therapeutic
efficiency
substantially.
In
this
review,
strategies
preparing
various
types
first
summarized.
We
highlight
advantages
under
different
species
polyphenol
ligands
application
treatments.
Finally,
some
current
problems
challenges
MPNs,
along
with
future
perspective
on
applications,
discussed.
Due
to
the
abuse
of
antibiotics
and
emergence
multidrug
resistant
microorganisms,
medical
devices,
related
biomaterials
are
at
high
risk
microbial
infection
during
use,
placing
a
heavy
burden
on
patients
healthcare
systems.
Metal-phenolic
networks
(MPNs),
an
emerging
organic-inorganic
hybrid
network
system
developed
gradually
in
recent
years,
have
exhibited
excellent
multifunctional
properties
such
as
anti-inflammatory,
antioxidant,
antibacterial
by
making
use
coordination
between
phenolic
ligands
metal
ions.
Further,
MPNs
received
widespread
attention
antimicrobial
infections
due
their
facile
synthesis
process,
biocompatibility,
brought
about
polyphenols
In
this
review,
different
categories
based
(nanoparticles,
coatings,
capsules,
hydrogels)
fabrication
strategies
summarized,
research
advances
applications
biomedical
fields
(e.g.,
skin
repair,
bone
regeneration,
etc.)
highlighted.
Advanced Materials,
Год журнала:
2023,
Номер
36(6)
Опубликована: Ноя. 24, 2023
Antibiotic-resistant
bacteria
pose
a
global
health
threat
by
causing
persistent
and
recurrent
microbial
infections.
To
address
this
issue,
antimicrobial
nanoparticles
(NPs)
with
low
drug
resistance
but
potent
bactericidal
effects
have
been
developed.
However,
many
of
the
developed
NPs
display
poor
biosafety
their
synthesis
often
involves
complex
procedures
modes
action
are
unclear.
Herein,
simple
strategy
is
reported
for
designing
metal-phenolic
network
(am-MPN)
through
one-step
assembly
seeding
agent
(diethyldithiocarbamate),
natural
polyphenols,
metal
ions
(e.g.,
Cu
Abstract
Current
diabetic
wound
treatments
remain
unsatisfactory
due
to
the
lack
of
a
comprehensive
strategy
that
can
integrate
strong
applicability
(tissue
adhesiveness,
shape
adaptability,
fast
self‐healability,
and
facile
dressing
change)
with
initiation
smooth
connection
cascade
healing
processes.
Herein,
benefiting
from
multifaceted
bonding
ability
tannic
acid
metal
ions
various
polymers,
family
tannin–europium
coordination
complex
crosslinked
citrate‐based
mussel‐inspired
bioadhesives
(TE‐CMBAs)
are
specially
developed
for
healing.
TE‐CMBAs
gel
instantly
(<
60
s),
possess
favorable
shape‐adaptability,
considerable
mechanical
strengths,
high
elasticity,
wet
tissue
adhesiveness
(≈40
kPa),
photothermal
antimicrobial
activity,
excellent
anti‐oxidant
biocompatibility,
angiogenetic
property.
The
reversible
hydrogen
bond
crosslinking
sensitive
metal–phenolic
also
confers
pH‐responsive
europium
ion
TA
releasing
properties
on‐demand
removability
upon
mixing
borax
solution,
enabling
convenient
painless
change
inflammatory
microenvironment
modulation,
angiogenesis
promotion,
effective
extracellular
matrix
production
leveraging
acidic
pH
condition
wounds.
This
adhesive
provides
regenerative
management
be
extended
other
complicated
scenarios.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(17)
Опубликована: Фев. 26, 2023
Abstract
Reducing
the
burden
of
death
due
to
wound
infection
is
an
urgent
global
public
health
priority.
Metal‐phenolic
networks
(MPNs)
have
received
widespread
attention
in
antimicrobial
infections
their
facile
synthesis
process,
excellent
biocompatibility,
and
properties
brought
about
by
polyphenols
metal
ions.
However,
typical
therapeutic
MPNs
show
rapid
release
ions
poor
solution
stability,
impeding
long‐acting
efficacy
multiple
healing
stages.
To
address
these
issues,
copper‐poly
(tannic
acid)
nanoparticles
(Cu‐PTA
NPs):
robust
(dually
crosslinked),
microenvironment‐responsive,
antibacterial,
antioxidative,
anti‐inflammatory
are
prepared,
which
hierarchically
modulate
infected
process.
Covalently
polymerized
via
phenol‐formaldehyde
condensation
crosslinked
with
bioactive
Cu
2+
,
reactive
preserved,
efficiently
entrapped
PTA
scaffold.
The
proposed
strategy
relieves
systemic
toxicity,
only
high
oxygen
species
(ROS)level
as
stimuli
can
“turn
on”
catalytic
activity
implement
antibacterial
therapy
specifically
wound.
Systematic
tissue
regeneration
assessment
on
full‐thickness
skin
wounds
rats
demonstrates
enhanced
rate.
Cu‐PTA
NPs
enables
direct
application
exertion
efficacy.
This
synergetic
will
pave
way
for
more
complicated
inflammatory
diseases.
Materials Today Bio,
Год журнала:
2023,
Номер
21, С. 100729 - 100729
Опубликована: Июль 11, 2023
Infectious
disease
is
one
of
the
top
10
causes
death
worldwide,
especially
in
low-income
countries.
The
extensive
use
antibiotics
has
led
to
an
increase
antibiotic
resistance,
which
poses
a
critical
threat
human
health
globally.
Natural
products
such
as
polyphenolic
compounds
and
their
derivatives
have
been
shown
positive
therapeutic
effects
antibacterial
therapy.
However,
inherent
physicochemical
properties
limit
pharmaceutical
effects,
short
half-lives,
chemical
instability,
low
bioavailability,
poor
water
solubility.
Nanoformulations
promising
advantages
improving
activity
by
controlling
release
drugs
enhancing
bioavailability
polyphenols.
In
this
review,
we
listed
classification
mechanisms
compounds.
More
importantly,
nanoformulations
for
delivery
polyphenols
agent
were
summarized,
including
different
types
nanoparticles
(NPs)
polymer-based
NPs,
metal-based
lipid-based
nanoscaffolds
nanogels,
nanofibers,
nanoemulsions.
At
same
time,
also
presented
potential
biological
applications
nano-system
enhance
ability
polyphenols,
aiming
provide
new
perspective
antibiotic-free
treatment
infectious
diseases.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(20)
Опубликована: Март 25, 2023
Treatment
of
infected
bone
defects
is
a
major
clinical
challenge;
bioactive
materials
combining
sufficient
antimicrobial
activity
and
favorable
osteogenic
ability
are
urgently
needed.
In
this
study,
through
facile
one-pot
hydrothermal
reaction
zinc
acetate
in
the
presence
tannic
acid
(TA),
with
or
without
silver
nitrate
(AgNO3
),
used
to
synthesize
TA
nanoparticles
(Ag
NPs)
bulk-modified
oxide
(ZnO)
(ZnO-TA
ZnO-TA-Ag),
which
further
composited
zein
fabricate
porous
microparticulate
scaffolds
for
defect
repair.
Bulk
modification
significantly
improves
release
rate
antibacterial
metal
ions
(Zn2+
>100
times
that
ZnO).
Fast
long-lasting
(>35
d)
Zn2+
Ag+
guaranteed
capability
excellent
properties
promoting
differentiation
marrow
mesenchymal
stem
cells
endogenous
citric
production
mineralization
providing
considerable
immunomodulatory
M2
polarization
macrophages.
At
same
time,
synchronously-released
could
scavenge
reactive
oxygen
species
(ROS)
ROS
produced
by
ions,
effectively
balancing
osteogenesis
sufficiently
control
infection
while
protecting
surrounding
tissue
from
damage,
thus
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 21, 2024
Novel
biomaterials
are
becoming
more
crucial
in
treating
human
diseases.
However,
many
materials
require
complex
artificial
modifications
and
synthesis,
leading
to
potential
difficulties
preparation,
side
effects,
clinical
translation.
Recently,
significant
progress
has
been
achieved
terms
of
direct
self-assembly
natural
products
from
herbal
medicine
(NPHM),
an
important
source
for
novel
medications,
resulting
a
wide
range
bioactive
supramolecular
including
gels,
nanoparticles.
The
NPHM-based
produced
renewable
resources,
simple
prepare,
have
demonstrated
multi-functionality
slow-release,
smart-responsive
release,
especially
possess
powerful
biological
effects
treat
various
In
this
review,
revealed
as
emerging,
revolutionary,
promising
strategy.
development,
advantages,
limitations
NPHM,
well
the
advantageous
position
materials,
first
reviewed.
Subsequently,
systematic
comprehensive
analysis
strategies
specific
seven
major
classes
NPHM
is
highlighted.
Insights
into
influence
structural
features
on
formation
also
provided.
Finally,
drivers
preparations
summarized,
emphasizing
biomedical
applications,
future
scientific
challenges,
opportunities,
with
hope
igniting
inspiration
research
applications.
ACS Nano,
Год журнала:
2024,
Номер
18(35), С. 24327 - 24349
Опубликована: Авг. 22, 2024
A
series
of
progress
has
been
made
in
the
field
antimicrobial
use
nanozymes
due
to
their
superior
stability
and
decreased
susceptibility
drug
resistance.
However,
catalytically
generated
reactive
oxygen
species
(ROS)
are
insufficient
for
coping
with
multidrug-resistant
organisms
(MDROs)
complex
wound
environments
low
targeting
ability
catalytic
activity.
To
address
this
problem,
chemically
stable
copper-gallic
acid-vancomycin
(CuGA-VAN)
nanoneedles
were
successfully
constructed
by
a
simple
approach
bacteria;
these
exhibit
OXD-like
GSH-px-like
dual
enzyme
activities
produce
ROS
induce
bacterial
cuproptosis-like
death,
thereby
eliminating
MDRO
infections.
The
results