Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1323 - 1323
Опубликована: Апрель 23, 2023
Metal–phenolic
networks
(MPNs)
are
a
new
type
of
nanomaterial
self-assembled
by
metal
ions
and
polyphenols
that
have
been
developed
rapidly
in
recent
decades.
They
widely
investigated,
the
biomedical
field,
for
their
environmental
friendliness,
high
quality,
good
bio-adhesiveness,
bio-compatibility,
playing
crucial
role
tumor
treatment.
As
most
common
subclass
MPNs
family,
Fe-based
frequently
used
chemodynamic
therapy
(CDT)
phototherapy
(PTT),
where
they
often
as
nanocoatings
to
encapsulate
drugs,
well
Fenton
reagents
photosensitizers
improve
therapeutic
efficiency
substantially.
In
this
review,
strategies
preparing
various
types
first
summarized.
We
highlight
advantages
under
different
species
polyphenol
ligands
application
treatments.
Finally,
some
current
problems
challenges
MPNs,
along
with
future
perspective
on
applications,
discussed.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Abstract
Surface
modification
is
an
important
approach
to
improve
osseointegration
of
the
endosseous
implants,
however
it
still
desirable
develop
a
facile
yet
efficient
coating
strategy.
Herein,
metal–phenolic
network
(MPN)
proposed
as
multifunctional
nanocoating
on
titanium
(Ti)
implants
for
enhanced
through
early
immunomodulation.
With
tannic
acid
(TA)
and
Sr
2+
self‐assembled
Ti
substrates,
MPN
coatings
provided
bioactive
interface,
which
can
facilitate
initial
adhesion
recruitment
bone
marrow
mesenchymal
stem
cells
(BMSCs)
polarize
macrophage
toward
M2
phenotype.
Furthermore,
TA‐Sr
accelerated
osteogenic
differentiation
BMSCs.
In
vivo
evaluations
further
confirmed
modified
via
generating
favorable
osteoimmune
microenvironment.
general,
these
results
suggest
that
promising
strategy
achieving
better
faster
be
easily
utilized
in
future
clinical
applications.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(22), С. 10800 - 10826
Опубликована: Янв. 1, 2024
This
review
provides
a
guideline
for
the
rational
design
of
metal–phenolic
network
(MPN)
composites—which
are
fabricated
from
MPN
and
one
or
more
functional
components
(
e.g.
,
drugs,
proteins)—for
various
applications
across
diverse
disciplines.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
International Journal of Microbiology,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
The
escalating
threat
of
infectious
diseases,
exacerbated
by
antimicrobial
resistance
(AMR)
and
biofilm
formation,
necessitates
innovative
therapeutic
strategies.
This
review
presents
a
comprehensive
exploration
the
potential
nanoparticles
synthesized
from
natural
sources,
including
plant
extracts,
microbial
products,
marine
compounds,
as
agents.
These
naturally
derived
demonstrated
significant
antibiofilm
antivirulence
effects,
with
specific
examples
revealing
their
capacity
to
reduce
mass
up
78%
inhibit
bacterial
quorum
sensing
65%.
integration
bioactive
such
polyphenols
chitosan,
facilitates
nanoparticle
stability
enhances
efficacy,
while
green
synthesis
protocols
environmental
risks.
Notably,
identifies
silver
using
tea
achieving
85%
inhibition
polymicrobial
growth
in
vitro.
Despite
these
promising
results,
challenges
standardization
scalability
persist.
study
underscores
transformative
leveraging
sourced
sustainable
alternatives
conventional
antimicrobials,
offering
quantitative
insights
for
future
application
combating
mono-
infections.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 2, 2025
Metal-phenolic
networks
(MPNs),
which
comprise
supramolecular
amorphous
formed
by
interlinking
polyphenols
with
metal
ions,
garner
escalating
interest
within
the
realm
of
nanomedicine.
Presently,
a
comprehensive
synthesis
cumulative
research
advancements
and
utilizations
MPNs
in
nanomedicine
remains
absent.
Thus,
this
review
endeavors
to
firstly
delineate
characteristic
polyphenols,
their
intricate
interaction
modalities
MPNs.
Subsequently,
it
elucidates
merits
demerits
diverse
methodologies
employed
for
MPNs,
alongside
exploring
potential
functional
attributes.
Furthermore,
consolidates
applications
across
various
nanomedical
domains
encompassing
tumor
therapy,
antimicrobial
interventions,
medical
imaging,
among
others.
Moreover,
meticulous
exposition
journey
from
ingress
into
human
body
eventual
excretion
is
provided.
Lastly,
persistent
challenges
promising
avenues
pertaining
are
delineated.
Hence,
offering
on
current
nanomedicine,
consequently
indirect
insights
clinical
implementation.
This
review
provides
a
comprehensive
evaluation
of
the
anti-tumor
bioactivities
and
delivery
strategies
dietary
polyphenols,
as
well
their
application
in
development
nano-therapeutic
systems
for
tumor.
