Fluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application

Science Advances, Год журнала: 2023, Номер 9(22)

Опубликована: Май 31, 2023

Continuous glucose monitoring (CGM) allows patients with diabetes to manage critical disease effectively and autonomously prevent exacerbation. A painless, wireless, compact, minimally invasive device that can provide CGM is essential for the health conditions of freely moving diabetes. Here, we propose a glucose-responsive fluorescence-based highly sensitive biodegradable microneedle system. These ultrathin ultralight sensor arrays continuously precisely monitored concentration in interstitial fluid invasive, pain-free, wound-free, skin inflammation-free outcomes at various locations thicknesses skin. Bioresorbability body without need removal after use was key characteristic sensor. We demonstrated potential long-term bioresorbable by applying tether-free system, thus confirming successful detection levels based on changes fluorescence intensity. In addition, this user-friendly designed home diagnosis system using mobile applications portable accessories offers an advance its applicability other bioresorbable, wearable, implantable technology.

Язык: Английский

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Porous Conductive Textiles for Wearable Electronics

Chemical Reviews, Год журнала: 2024, Номер 124(4), С. 1535 - 1648

Опубликована: Фев. 19, 2024

Over the years, researchers have made significant strides in development of novel flexible/stretchable and conductive materials, enabling creation cutting-edge electronic devices for wearable applications. Among these, porous textiles (PCTs) emerged as an ideal material platform electronics, owing to their light weight, flexibility, permeability, wearing comfort. This Review aims present a comprehensive overview progress state art utilizing PCTs design fabrication wide variety integrated systems. To begin with, we elucidate how revolutionize form factors electronics. We then discuss preparation strategies PCTs, terms raw processes, key properties. Afterward, provide detailed illustrations are used basic building blocks fabricate intrinsically flexible or stretchable devices, including sensors, actuators, therapeutic energy-harvesting storage displays. further describe techniques systems either by hybridizing conventional off-the-shelf rigid components with integrating multiple fibrous PCTs. Subsequently, highlight some important application scenarios healthcare, sports training, converging technologies, professional specialists. At end Review, challenges perspectives on future research directions give overall conclusions. As demand more personalized interconnected continues grow, PCT-based wearables hold immense potential redefine landscape technology reshape way live, work, play.

Язык: Английский

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Ultra‐Thin Flexible Encapsulating Materials for Soft Bio‐Integrated Electronics

Advanced Science, Год журнала: 2022, Номер 9(30)

Опубликована: Авг. 28, 2022

Abstract Recently, bioelectronic devices extensively researched and developed through the convergence of flexible biocompatible materials electronics design that enables more precise diagnostics therapeutics in human health care opens up potential to expand into various fields, such as clinical medicine biomedical research. To establish an accurate stable bidirectional bio‐interface, protection against external environment high mechanical deformation is essential for wearable devices. In case implantable bioelectronics, special encapsulation optimized designs configurations provide electronic stability functionality are required accommodating organ properties, lifespans, functions biofluid environment. Here, this study introduces recent developments ultra‐thin encapsulations with novel can preserve or even improve electrical performance bio‐integrated by supporting safety from destruction contamination well optimizing use systems physiological environments. addition, a summary materials, methods, characteristics most widely used technologies introduced, thereby providing strategic selection appropriate choices recently bioelectronics.

Язык: Английский

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Soft bioelectronics for the management of cardiovascular diseases

Nature Reviews Bioengineering, Год журнала: 2023, Номер 2(1), С. 8 - 24

Опубликована: Сен. 29, 2023

Язык: Английский

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Mechanoresponsive Flexible Crystals

JACS Au, Год журнала: 2024, Номер 4(2), С. 279 - 300

Опубликована: Янв. 16, 2024

Flexible crystals have gained significant attention owing to their remarkable pliability, plasticity, and adaptability, making them highly popular in various research application fields. The main challenges developing flexible lie the rational design, preparation, performance optimization of such crystals. Therefore, a comprehensive understanding fundamental origins crystal flexibility is crucial for establishing evaluation criteria design principles. This Perspective offers retrospective analysis development over past two decades. It summarizes elastic standards possible plastic bending mechanisms tailored diverse analyzes assessment theoretical basis applicability. Meanwhile, compatibility between elasticity plasticity has been discussed, unveiling immense prospects elastic/plastic applications biomedicine, electronic devices, optics. Furthermore, this presents state-of-the-art experimental avenues methods investigating molecular interactions crystals, which vital future exploration flexibility.

Язык: Английский

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A skin-wearable and self-powered laminated pressure sensor based on triboelectric nanogenerator for monitoring human motion

Soft Science, Год журнала: 2024, Номер 4(1)

Опубликована: Янв. 26, 2024

Flexible and skin-wearable triboelectric nanogenerators (TENGs) have emerged as promising candidates for self-powered tactile pressure sensors mechanical energy harvesters due to their compatible design ability operate at low frequencies. Most research has focused on improving tribo-negative materials flexible TENGs, given the limited options tribo-positive materials. Achieving biocompatibility while maintaining sensitivity capability of harvesting is another critical issue wearable sensors. Here, we report a TENG-based biocompatible sensor by simple fabrication layer-by-layer deposition methods. The Laminated Flexible-TENG comprises polytetrafluoroethylene (PTFE) polymethyl methacrylate (PMMA) films embedded within polydimethylsiloxane (PDMS) matrix. A nanostructured PDMS surface obtained oxygen plasma facilitated sputter layered indium tin oxide copper electrode PMMA thin layer top. addition significantly improved quality performance oxide-copper electrode. Self-powered Flexible-TENGs demonstrated impressive pressure-sensing capabilities, featuring dual 7.287 V/kPa 0.663 higher pressure. Moreover, PDMS-encapsulated TENG effectively traced physiological motions, such wrist finger bending, efficiently harnessed waste from everyday physical activities, walking jogging. maximum peak-to-peak voltages 18.3 57.4 V were recorded during these motions. Encapsulated TENGs broad potential in technology, including healthcare, human-machine interfaces, energizing microelectronics.

Язык: Английский

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Flexible Pressure, Humidity, and Temperature Sensors for Human Health Monitoring

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Abstract The rapid advancements in artificial intelligence, micro‐nano manufacturing, and flexible electronics technology have unleashed unprecedented innovation opportunities for applying sensors healthcare, wearable devices, human–computer interaction. human body's tactile perception involves physical parameters such as pressure, temperature, humidity, all of which play an essential role maintaining health. Inspired by the sensory function skin, many bionic been developed to simulate skin's various stimuli are widely applied health monitoring. Given urgent requirements sensing performance integration field devices monitoring, here is a timely overview recent advances multi‐functional It covers fundamental components categorizes them based on different response mechanisms, including resistive, capacitive, voltage, other types. Specifically, application these area monitoring highlighted. Based this, extended dual/triple‐mode integrating temperature presented. Finally, challenges discussed.

Язык: Английский

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4D printed bio-inspired mesh composite materials with high stretchability and reconfigurability

Composites Science and Technology, Год журнала: 2024, Номер 249, С. 110503 - 110503

Опубликована: Фев. 15, 2024

Язык: Английский

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Bioelectronic Implantable Devices for Physiological Signal Recording and Closed‐Loop Neuromodulation

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 8, 2024

Abstract Bioelectronic implantable devices are adept at facilitating continuous monitoring of health and enabling the early detection diseases, offering insights into physiological conditions various bodily organs. Furthermore, these advanced systems have therapeutic capabilities in neuromodulation, demonstrating their efficacy addressing diverse medical through precise delivery stimuli directly to specific targets. This comprehensive review explores developments applications bioelectronic within biomedical field. Special emphasis is placed on evolution closed‐loop systems, which stand out for dynamic treatment adjustments based real‐time feedback. The integration Artificial Intelligence (AI) edge computing technologies discussed, significantly bolster diagnostic functions devices. By elemental analyses, current challenges, future directions devices, aims guide pathway advances

Язык: Английский

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Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges

Journal of Tissue Engineering, Год журнала: 2025, Номер 16

Опубликована: Янв. 1, 2025

The field of three dimensional (3D) bioprinting has witnessed significant advancements, with bioinks playing a crucial role in enabling the fabrication complex tissue constructs. This review explores innovative that are currently shaping future 3D bioprinting, focusing on their composition, functionality, and potential for engineering, drug delivery, regenerative medicine. development bioinks, incorporating natural synthetic materials, offers unprecedented opportunities personalized However, rapid technological progress raises regulatory challenges regarding safety, standardization, long-term biocompatibility. paper addresses these challenges, examining current frameworks need updated guidelines to ensure patient safety product efficacy. By highlighting both hurdles, this comprehensive overview landscape emphasizing necessity cross-disciplinary collaboration between scientists, clinicians, bodies achieve successful clinical applications.

Язык: Английский

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