Alginate-PVDF piezoelectric hydrogel containing calcium copper titanate- hydroxyapatite as a self-powered scaffold for bone tissue engineering and energy harvesting

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 687, С. 133537 - 133537

Опубликована: Фев. 23, 2024

Язык: Английский

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Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Фев. 13, 2024

Abstract Modulating cellular functions at the dental implant‐tissue interface to augment integration and prevent bacterial ingress is crucial for achieving early stability long‐term implant success. Nano‐engineering strategies, such as anodized titanium implants with titania (TiO 2 ) nanotubes/nanopores, are emerging a promising surface modification approach enhance infection. Achieving on‐demand therapy through electrical stimulation (EST, supply of voltage/current local tissue) may be advantageous but has not been explored implants. Further, TiO nanotubes/nanopores represent semi‐conducting that can impede EST effectiveness. In this pioneering study, nanopores converted into conducting Ti perform achieve superior soft‐tissue antibacterial efficacy. In‐depth characterizations followed by assays investigating effect on cultured human salivary biofilm gingival fibroblasts. Significant bactericidal efficacy demonstrated (1.5 V 5 min per day) using nanopores. enhanced fibroblast proliferation collagen secretion. summary, applied nanoporous promotes healing proposed next‐generation in dentistry therapy.

Язык: Английский

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Advancing Osteoporotic Bone Regeneration Through Tailored Tea Polyphenols Functionalized Micro‐/Nano‐ Hydroxyapatite Bioceramics

Advanced Functional Materials, Год журнала: 2024, Номер 34(32)

Опубликована: Май 6, 2024

Abstract Efforts to develop advanced bone substitutes for effective regeneration in substantial defects have led the fabrication of tissue‐engineered scaffolds. These scaffolds, featuring hierarchical structures, specific chemical compositions, and functional qualities, are essential mimicking native tissue. Inspired by biomineralization process, hydrothermal treatment is used synthesize micro‐/nano‐hydroxyapatite bioceramics functionalized with tea polyphenols (TP‐nwHA), closely resembling structure bone‐like apatite induced hydroxyapatite vivo. The vitro results demonstrate TP‐nwHA's superior biocompatibility, enhancing cell proliferation adhesion. Furthermore, TP‐nwHA scaffolds significantly influence mesenchymal stem cells, promoting osteogenic differentiation while inhibiting osteoclastogenic differentiation. upregulation proteins BMP2 ITGB1, along downregulation osteoclastic FGF21 IGFBP1, synergistic effect biomimetic on activation MAPK signaling pathway. In vivo, showe early angiogenic capabilities, leading improved critical‐size femoral osteoporotic rats. Histological staining confirms complete bridging new tissue group, nanoindentation tests indicate formation mature mineralized Collectively, these findings suggest a novel strategy fabricating bone‐mimicking constructs potential applications disease modeling.

Язык: Английский

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Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 51, С. 94 - 107

Опубликована: Фев. 4, 2025

Язык: Английский

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Piezoelectric Hydrogel with Self-Powered Biomechanical Stimulation Enhances Bone Regeneration

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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