Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 185 - 202
Опубликована: Март 5, 2024
Wound
healing
in
cases
of
excessive
inflammation
poses
a
significant
challenge
due
to
compromised
neovascularization.
Here,
we
propose
multi-functional
composite
hydrogel
engineered
overcome
such
conditions
through
recruitment
and
activation
macrophages
with
adapted
degradation
the
hydrogel.
The
(G-TSrP)
is
created
by
combining
gelatin
methacryloyl
(GelMA)
nanoparticles
(TSrP)
composed
tannic
acid
(TA)
Sr2+.
These
are
prepared
using
one-step
mineralization
process
assisted
metal-phenolic
network
formation.
G-TSrP
exhibits
ability
eliminate
reactive
oxygen
species
direct
polarization
toward
M2
phenotype.
It
has
been
observed
that
liberation
TA
Sr2+
from
actively
facilitate
up-regulation
expression
extracellular
matrix
remodeling
genes
macrophages,
thereby,
coordinate
vivo
G-TSrP.
Most
significantly,
accelerates
angiogenesis
despite
TA's
inhibitory
properties,
which
counteracted
released
Moreover,
enhances
wound
closure
under
promotes
normal
tissue
formation
strong
vessel
growth.
Genetic
analysis
confirms
macrophage-mediated
Collectively,
these
findings
pave
way
for
development
biomaterials
promote
creating
regenerative
environment.
Abstract
Macrophages
are
versatile
immune
cells
with
remarkable
plasticity,
enabling
them
to
adapt
diverse
tissue
microenvironments
and
perform
various
functions.
Traditionally
categorized
into
classically
activated
(M1)
alternatively
(M2)
phenotypes,
recent
advances
have
revealed
a
spectrum
of
macrophage
activation
states
that
extend
beyond
this
dichotomy.
The
complex
interplay
signaling
pathways,
transcriptional
regulators,
epigenetic
modifications
orchestrates
polarization,
allowing
respond
stimuli
dynamically.
Here,
we
provide
comprehensive
overview
the
cascades
governing
focusing
on
roles
Toll‐like
receptors,
signal
transducer
activator
transcription
proteins,
nuclear
microRNAs.
We
also
discuss
emerging
concepts
metabolic
reprogramming
trained
immunity,
contributing
their
functional
adaptability.
Macrophage
plasticity
plays
pivotal
role
in
repair
regeneration,
macrophages
coordinating
inflammation,
angiogenesis,
matrix
remodeling
restore
homeostasis.
By
harnessing
potential
novel
therapeutic
strategies
targeting
polarization
could
be
developed
for
diseases,
including
chronic
wounds,
fibrotic
disorders,
inflammatory
conditions.
Ultimately,
deeper
understanding
molecular
mechanisms
underpinning
will
pave
way
innovative
regenerative
medicine
engineering
approaches.
Advanced Materials,
Год журнала:
2024,
Номер
36(19)
Опубликована: Фев. 7, 2024
Current
approaches
to
treating
inflammatory
bowel
disease
focus
on
the
suppression
of
overactive
immune
responses,
removal
reactive
intestinal
oxygen
species,
and
regulation
flora.
However,
owing
complex
structure
gastrointestinal
tract
influence
mucus,
current
small-molecule
biologic-based
drugs
for
colitis
cannot
effectively
act
at
site
colon
inflammation,
as
a
result,
they
tend
exhibit
low
efficacies
toxic
side
effects.
In
this
study,
nanogel-based
multistage
NO
delivery
microcapsules
are
developed
achieve
release
inflammation
by
targeting
tissues
using
nanogel.
Surprisingly,
oral
administration
suppresses
growth
pathogenic
bacteria
increases
abundance
probiotic
bacteria.
Metabolomics
further
show
that
an
increased
probiotics
promotes
production
metabolites,
including
short-chain
fatty
acids
indole
derivatives,
which
modulate
immunity
restore
barrier
via
interleukin-17
PI3K-Akt
signaling
pathways.
This
work
reveals
gas
therapy
strategy
based
modulates
microbial
balance,
thereby
reducing
promoting
repair,
ultimately
providing
new
therapeutic
approach
clinical
management
colitis.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(8), С. 9749 - 9767
Опубликована: Фев. 15, 2024
The
treatment
of
diabetic
chronic
wounds
is
still
faced
with
great
challenges,
mainly
due
to
wound
infection,
excessive
inflammation,
and
peripheral
vascular
disease
in
the
area.
Therefore,
it
importance
develop
a
novel
multifunctional
hydrogel
high
efficiency
accelerate
healing.
Curcumin
(Cur),
Chinese
herbal,
has
shown
potential
enhancing
healing
because
its
immunomodulatory
pro-angiogenic
properties.
However,
low
aqueous
solubility,
poor
bioavailability,
chemical
instability
have
limited
clinical
applications.
To
address
these
current
bottlenecks,
poly(vinyl
alcohol)
(PVA)–chitosan
(CS)/sodium
alginate
(SA)–Cur
(PCSA)
hydrogels
were
prepared
for
first
time,
they
demonstrated
all
above
intriguing
performances
by
Michael
addition
reaction
CS
Cur.
PCSA
show
multiple
dynamic
bonds,
which
possess
strong
mechanical
properties
(tensile
stress:
∼0.980
MPa;
toughness:
∼258.45
kJ/m3;
compressive
strength:
∼7.38
MPa
at
strain
80%).
These
provided
an
optimal
microenvironment
cell
migration
proliferation
also
promoted
growth
blood
vessels,
leading
early
angiogenesis.
Importantly,
experimental
results
that
can
effectively
transform
pro-inflammatory
M1
macrophages
into
anti-inflammatory
M2
without
need
additional
ingredients
vitro.
Benefiting
from
characteristics,
full-thickness
rat
model
via
ROS-scavenging,
downregulation
IL-1β,
upregulation
CD31
expression,
resulting
angiogenesis
collagen
deposition.
This
strategy
not
only
provides
simple
safe
Cur-based
but
highlights
significant
development
high-performance
biomaterials
promoting
using
traditional
medicine.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 6, 2024
Tibial
Cortex
Transverse
Transport
(TTT)
represents
an
innovative
surgical
method
for
treating
lower
extremity
diabetic
foot
ulcers
(DFUs),
yet
its
underlying
mechanisms
remain
elusive.
Establishing
animal
model
that
closely
mirrors
clinical
scenarios
is
both
critical
and
novel
elucidating
the
of
TTT.
