Journal of Biomedical Materials Research Part A,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Oral
ulcers
are
one
of
the
most
common
oral
diseases
in
clinical
practice.
Its
etiology
is
complex
and
varied.
Due
to
dynamic
nature
environment,
wound
surface
painful
due
contact
wear,
which
seriously
affects
quality
life
patients.
often
treated
with
topical
drug
therapy.
Studies
have
shown
that
functional
hydrogels
play
a
positive
role
promoting
healing,
showing
unique
advantages
dressings.
In
this
paper,
causes
healing
characteristics
discussed
depth,
then
treatment
methods
for
summarized
compared.
Finally,
potential
projected
through
review
literature
recent
years.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
Inflammation
is
a
vital
immune
response,
tightly
orchestrated
through
both
biochemical
and
biophysical
cues.
Dysregulated
inflammation
contributes
to
chronic
diseases,
highlighting
the
need
for
novel
therapies
that
modulate
responses
with
minimal
side
effects.
While
several
pathways
of
are
well
understood,
influence
physical
properties
such
as
substrate
curvature
on
cell
behavior
remains
underexplored.
This
study
investigates
how
impacts
macrophage
cytoskeletal
dynamics,
gene
expression,
immunophenotype
mechanosensitive
pathways.
Gelatin-based
microgels
tunable
surface
curvatures
were
fabricated
via
water-in-oil
emulsification
crosslinked
genipin.
Microgels
sorted
into
three
size
ranges,
yielding
high
(40-50
µm),
intermediate
(150-250
low
(350-400
µm)
profiles.
Macrophages
seeded
onto
these
microgels,
dynamics
examined
using
confocal
microscopy,
SEM,
actin-specific
staining.
Gene
expression
pro-
anti-inflammatory
markers
was
quantified
qPCR.
The
role
actin
polymerization
assessed
Latrunculin-A
(Lat-A)
treatment.
adhered
effectively
high-
low-curvature
displaying
curvature-dependent
morphological
changes.
Confocal
imaging
revealed
macrophages
exhibited
significantly
higher
F-actin
density
than
those
high-curvature
microgels.
Correspondingly,
qPCR
analysis
showed
upregulation
pro-inflammatory
(e.g.,
Tnf,
Nos2)
in
conditions,
while
Arg1)
elevated
conditions.
Lat-A
treatment
reduced
modulated
patterns,
confirming
regulation
phenotype.
These
findings
demonstrate
influences
by
modulating
associated
immunophenotypic
actin-mediated
transcriptional
By
controlling
curvature,
therapeutic
biomaterials
may
direct
responses,
offering
new
avenue
treating
inflammatory
diseases.
mechanobiological
approach
presents
promising
strategy
precision
immunomodulation
regenerative
medicine.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Inflammatory
responses
play
a
central
role
in
coordinating
biomaterial‐mediated
tissue
regeneration.
However,
precise
modulation
of
dynamic
variations
microenvironmental
inflammation
post‐implantation
remains
challenging.
In
this
study,
the
traditional
β‐tricalcium
phosphate‐based
scaffold
is
remodeled
via
ultrathin
MXene‐Ti
3
C
2
decoration
and
Zn
2+
/Sr
ion‐substitution,
endowing
with
excellent
reactive
oxygen
species‐scavenging
ability,
near‐infrared
responsivity,
enhanced
mechanical
properties.
The
induction
mild
hyperthermia
around
implant
periodic
irradiation
facilitates
spatiotemporal
regulation
inflammatory
cytokines
secreted
by
spectrum
macrophage
phenotypes.
process
initially
amplifies
pro‐inflammatory
response,
then
accelerates
M1‐to‐M2
polarization
transition,
yielding
satisfactory
pattern
osteo‐immunomodulation
during
natural
bone
healing
process.
Later,
sustained
release
ions
gradual
degradation
3D
maintains
favorable
reparative
M2‐dominated
immunological
microenvironment
that
supports
new
mineralization.
Precise
temporal
immunoregulation
intelligent
enhances
regeneration
rat
cranial
defect
model.
This
strategy
paves
way
for
application
materials
to
guide
toward
outcome,
making
clinical
treatment
more
predictable
durable.
findings
also
demonstrate
irradiation‐derived
promising
method
immunomodulation.
