Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
In
recent
years,
tumor
immunotherapy
has
made
significant
breakthroughs
in
the
treatment
of
malignant
tumors.
However,
individual
differences
efficacy
have
been
observed
clinical
practice.
There
is
increasing
evidence
that
gut
microbial
metabolites
influence
distal
via
gut-liver
axis,
gut-brain
axis
and
gut-breast
a
process
may
involve
modulating
expression
immune
cells
cytokines
microenvironment
(TME).
this
review,
we
systematically
explore
relationship
between
immunotherapy,
examine
corresponding
natural
products
their
mechanisms
action.
The
in-depth
exploration
research
area
will
provide
new
ideas
strategies
to
enhance
mitigate
adverse
effects.
Abstract
Gut
microbiota‐derived
metabolites
are
key
hubs
connecting
the
gut
microbiome
and
cancer
progression,
primarily
by
remodeling
tumor
microenvironment
regulating
signaling
pathways
in
cells
multiple
immune
cells.
The
use
of
microbial
radiotherapy
chemotherapy
mitigates
severe
side
effects
from
treatment
improves
efficacy
treatment.
Immunotherapy
combined
with
effectively
activates
system
to
kill
tumors
overcomes
drug
resistance.
Consequently,
various
novel
strategies
have
been
developed
modulate
metabolites.
Manipulation
genes
involved
metabolism
using
synthetic
biology
approaches
directly
affects
levels
metabolites,
while
fecal
transplantation
phage
affect
altering
composition
microbiome.
However,
some
harbor
paradoxical
functions
depending
on
context
(e.g.,
type
cancer).
Furthermore,
metabolic
microorganisms
certain
anticancer
drugs
such
as
irinotecan
gemcitabine,
render
ineffective
or
exacerbate
their
adverse
effects.
Therefore,
a
personalized
comprehensive
consideration
patient's
condition
is
required
when
employing
treat
cancer.
purpose
this
review
summarize
correlation
between
cancer,
provide
fresh
ideas
for
future
scientific
research.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Environmental Toxicology,
Год журнала:
2024,
Номер
39(6), С. 3448 - 3472
Опубликована: Март 7, 2024
Globally,
breast
cancer,
with
diverse
subtypes
and
prognoses,
necessitates
tailored
therapies
for
enhanced
survival
rates.
A
key
focus
is
glutamine
metabolism,
governed
by
select
genes.
This
study
explored
genes
associated
T
cells
linked
them
to
metabolism
construct
a
prognostic
staging
index
cancer
patients
more
precise
medical
treatment.
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 270 - 270
Опубликована: Фев. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Biomimetics,
Год журнала:
2025,
Номер
10(2), С. 73 - 73
Опубликована: Янв. 24, 2025
The
gut
microbiota
is
a
complex
and
dynamic
ecosystem
that
plays
fundamental
role
in
human
health
by
regulating
immunity,
metabolism,
the
gut–brain
axis.
Beyond
its
critical
physiological
functions,
it
has
emerged
as
rich
source
of
inspiration
for
biomimetic
innovations
healthcare
biotechnology.
This
review
explores
transformative
potential
microbiota-based
biomimetics,
focusing
on
key
biological
mechanisms
such
resilience,
self-regulation,
quorum
sensing.
These
have
inspired
development
innovative
applications,
including
personalized
probiotics,
synbiotics,
artificial
microbiomes,
bioinspired
biosensors,
bioremediation
systems.
Such
technologies
aim
to
emulate
optimize
intricate
functions
microbial
ecosystems,
addressing
challenges
environmental
sustainability.
integration
advanced
technologies,
intelligence,
bioengineering,
multi-omics
approaches,
further
accelerated
biomimetics.
tools
enable
precision
therapies
tailored
individual
profiles,
enhance
efficacy
diagnostic
systems,
facilitate
design
environmentally
sustainable
solutions,
waste-to-energy
systems
platforms.
Emerging
areas
innovation,
gut-on-chip
models
synthetic
biology,
offer
unprecedented
opportunities
studying
applying
principles
controlled
environments.
Despite
these
advancements,
remain.
replication
complexity
environments,
ethical
concerns
regarding
genetically
engineered
microorganisms,
equitable
access
are
hurdles
must
be
addressed.
underscores
importance
interdisciplinary
collaboration
public
awareness
overcoming
barriers
ensuring
responsible
solutions.
By
leveraging
biomimetics
represents
promising
frontier
approach
revolutionize
therapeutic
strategies,
redefine
tools,
address
global
challenges,
paving
way
more
personalized,
efficient,
future
medicine
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Апрель 19, 2024
All
microorganisms
like
bacteria,
viruses
and
fungi
that
reside
within
a
host
environment
are
considered
microbiome.
The
number
of
bacteria
almost
equal
human
cells,
however,
the
genome
these
may
be
100
times
larger
than
genome.
Every
aspect
physiology
health
can
influenced
by
microbiome
living
in
various
parts
our
body.
Any
imbalance
composition
or
function
is
seen
as
dysbiosis.
Different
types
dysbiosis
corresponding
symptoms
depend
on
site
microbial
imbalance.
contribution
intestinal
extra-intestinal
microbiota
to
influence
systemic
activities
through
interplay
between
different
axes.
Whole
body
complex
process
involving
gut
non-gut
related
It
still
at
stage
infancy
has
not
yet
been
fully
understood.
Dysbiosis
genetic
factors,
lifestyle
habits,
diet
including
ultra-processed
foods
food
additives,
well
medications.
associated
with
many
diseases
cannot
diagnosed
standard
blood
tests
investigations.
Microbiota
derived
metabolites
analyzed
useful
management
addressed
altering
proper
modulation.
effect
interventions
humans
depends
beneficial
alteration
mostly
based
animal
studies
evolving
evidence
from
studies.
There
tremendous
potential
for
diagnosis,
treatment,
prognosis
diseases,
as,
monitoring
disease
humans.
system-based
approach
diagnosis
better
pure
taxonomic
approach.
could
new
therapeutic
target
conditions.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
173, С. 116420 - 116420
Опубликована: Март 11, 2024
Gut
microbiome
alterations
are
associated
with
various
cancers
including
brain
tumours
such
as
glioma
and
glioblastoma.
The
gut
communicates
the
via
a
bidirectional
pathway
known
gut-brain
axis
(GBA)
which
is
essential
for
maintaining
homeostasis.
microbiota
produces
many
metabolites
short
chain
fatty
acids
(SCFAs)
amino
glutamate,
glutamine,
arginine
tryptophan.
Through
modulation
of
these
able
to
regulate
several
functions
cells,
immune
cells
tumour
DNA
methylation,
mitochondrial
function,
aryl
hydrocarbon
receptor
(AhR),
T-cell
proliferation,
autophagy
even
apoptosis.
Here,
we
summarise
current
findings
on
respect
cancers,
an
area
research
that
widely
overlooked.
Several
studies
investigated
relationship
between
tumours.
However,
it
remains
unclear
whether
variation
cause
or
product
cancer.
Subsequently,
biomarker
panel
was
constructed
use
predictive,
prognostic
diagnostic
tool
multiple
glioblastoma
multiforme
(GBM).
This
review
further
presents
intratumoural
microbiome,
fascinating
microenvironment
within
possible
treatment
target
can
be
manipulated
maximise
effectiveness
personalised
therapy.
Studies
utilising
therapeutic
strategy
necessary
accurately
assess
clinical
cancers.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 15, 2024
Chimeric
antigen
receptor
(CAR)
-T
cell
therapy
has
achieved
tremendous
efficacy
in
the
treatment
of
hematologic
malignancies
and
represents
a
promising
regimen
for
cancer.
Despite
striking
response
patients
with
malignancies,
most
solid
tumors
treated
CAR-T
cells
have
low
rate
experience
major
adverse
effects,
which
indicates
need
biomarkers
that
can
predict
improve
clinical
outcomes
future
treatments.
Recently,
role
gut
microbiota
cancer
been
established,
growing
evidence
suggested
signatures
may
be
harnessed
to
personally
therapeutic
or
effects
optimizing
therapy.
In
this
review,
we
discuss
current
understanding
microbiota,
interplay
between
Above
all,
highlight
potential
strategies
challenges
harnessing
as
predictor
modifier
while
attenuating
toxicity.
