A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(15)

Published: March 23, 2023

Abstract Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling tumor microenvironment regulating signaling pathways in cells multiple immune cells. The use of microbial radiotherapy chemotherapy mitigates severe side effects from treatment improves efficacy treatment. Immunotherapy combined with effectively activates system to kill tumors overcomes drug resistance. Consequently, various novel strategies have been developed modulate metabolites. Manipulation genes involved metabolism using synthetic biology approaches directly affects levels metabolites, while fecal transplantation phage affect altering composition microbiome. However, some harbor paradoxical functions depending on context (e.g., type cancer). Furthermore, metabolic microorganisms certain anticancer drugs such as irinotecan gemcitabine, render ineffective or exacerbate their adverse effects. Therefore, a personalized comprehensive consideration patient's condition is required when employing treat cancer. purpose this review summarize correlation between cancer, provide fresh ideas for future scientific research.

Language: Английский

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Tumor microenvironment as a complex milieu driving cancer progression: a mini review

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

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Precision unveiled: Synergistic genomic landscapes in breast cancer—Integrating single‐cell analysis and decoding drug toxicity for elite prognostication and tailored therapeutics

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(6), P. 3448 - 3472

Published: March 7, 2024

Globally, breast cancer, with diverse subtypes and prognoses, necessitates tailored therapies for enhanced survival rates. A key focus is glutamine metabolism, governed by select genes. This study explored genes associated T cells linked them to metabolism construct a prognostic staging index cancer patients more precise medical treatment.

Language: Английский

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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

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Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

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Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

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Exploring the gut microbiota and its potential as a biomarker in gliomas

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116420 - 116420

Published: March 11, 2024

Gut microbiome alterations are associated with various cancers including brain tumours such as glioma and glioblastoma. The gut communicates the via a bidirectional pathway known gut-brain axis (GBA) which is essential for maintaining homeostasis. microbiota produces many metabolites short chain fatty acids (SCFAs) amino glutamate, glutamine, arginine tryptophan. Through modulation of these able to regulate several functions cells, immune cells tumour DNA methylation, mitochondrial function, aryl hydrocarbon receptor (AhR), T-cell proliferation, autophagy even apoptosis. Here, we summarise current findings on respect cancers, an area research that widely overlooked. Several studies investigated relationship between tumours. However, it remains unclear whether variation cause or product cancer. Subsequently, biomarker panel was constructed use predictive, prognostic diagnostic tool multiple glioblastoma multiforme (GBM). This review further presents intratumoural microbiome, fascinating microenvironment within possible treatment target can be manipulated maximise effectiveness personalised therapy. Studies utilising therapeutic strategy necessary accurately assess clinical cancers.

Language: Английский

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Approach to the diagnosis and management of dysbiosis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 19, 2024

All microorganisms like bacteria, viruses and fungi that reside within a host environment are considered microbiome. The number of bacteria almost equal human cells, however, the genome these may be 100 times larger than genome. Every aspect physiology health can influenced by microbiome living in various parts our body. Any imbalance composition or function is seen as dysbiosis. Different types dysbiosis corresponding symptoms depend on site microbial imbalance. contribution intestinal extra-intestinal microbiota to influence systemic activities through interplay between different axes. Whole body complex process involving gut non-gut related It still at stage infancy has not yet been fully understood. Dysbiosis genetic factors, lifestyle habits, diet including ultra-processed foods food additives, well medications. associated with many diseases cannot diagnosed standard blood tests investigations. Microbiota derived metabolites analyzed useful management addressed altering proper modulation. effect interventions humans depends beneficial alteration mostly based animal studies evolving evidence from studies. There tremendous potential for diagnosis, treatment, prognosis diseases, as, monitoring disease humans. system-based approach diagnosis better pure taxonomic approach. could new therapeutic target conditions.

Language: Английский

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Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130959 - 130959

Published: March 17, 2024

Language: Английский

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Unveiling the intratumoral microbiota within cancer landscapes

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109893 - 109893

Published: May 3, 2024

Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, viruses within tumor tissues, been found to exert considerable influence on development, progression, efficacy therapeutic interventions. This review aims synthesize these groundbreaking discoveries, providing an integrated overview identification, characterization, functional roles microbiota biology. We focus elucidating complex interactions between microorganisms microenvironment, highlighting their potential as novel biomarkers targets. The purpose this is offer comprehensive understanding dimension cancer, paving way for innovative approaches diagnosis treatment.

Language: Английский

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