Pharmacological Research,
Год журнала:
2025,
Номер
213, С. 107636 - 107636
Опубликована: Фев. 1, 2025
FOLFOX
(5-Fluorouracil,
Calcium
Folinate
combined
with
Oxaliplatin)
is
a
preferred
chemotherapy
regimen
for
colon
cancer,
but
its
limited
efficacy
remains
major
challenge,
significantly
impairs
patient
outcomes.
There
an
urgent
need
to
identify
strategies
improve
therapeutic
effectiveness.
Our
previous
studies
have
suggested
that
gut
microbiota-derived
bile
acids
may
be
involved
in
the
anticancer
effect
of
vitro,
however,
underlying
mechanism
unclear.
In
this
study,
we
investigated
role
modulating
and
related
mechanisms.
We
first
demonstrated
depletion
(cholestyramine
treatment)
enhanced
orthotopic
cancer
mouse
model,
suggesting
play
key
FOLFOX's
effects.
Further,
based
on
system
screen
15
via
MTT,
colony
formation
flow
cytometry
assay,
Deoxycholic
Acid
(DCA)
Glycodeoxycholic
(GDCA)
were
annotated
as
potential
modulators
efficacy.
Among
these,
DCA
was
further
validated
enhance
anti-colon
effects
vivo.
Transcriptomic
analysis
subsequent
biological
experiments
revealed
Ugt1a6b.
conclusion,
our
findings
establish
enhances
potentially
Ugt1a6b
mediated
enterohepatic
circulation,
providing
novel
insights
into
synergistic
strategy
improving
treatment.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Abstract
Radiation
colitis
is
one
of
the
most
common
complications
in
patients
undergoing
pelvic
radiotherapy
and
there
no
effective
treatment
clinic.
Therefore,
searching
for
agents
radiation
urgently
needed.
Herein,
it
found
that
essential
element
selenium
(Se)
protective
against
through
inhibiting
X‐ray‐induced
apoptosis,
cell
cycle
arrest,
inflammation
with
involvement
balancing
generation
reactive
oxygen
species
after
irradiation.
Mechanistically,
Se,
especially
nanoparticles
(SeNPs),
induced
selenoprotein
expression
then
functioned
to
effectively
restrain
DNA
damage
response,
which
reduced
intestinal
injury.
Additionally,
SeNPs
also
restrained
cyclic
GMP‐AMP
synthas
(cGAS)‐
stimulator
interferon
genes
(STING)‐TBK1‐IRF3
signaling
pathway
cascade,
thereby
blocking
transcription
inflammatory
cytokine
gene,
IL‐6
TNF‐α,
thus
alleviating
inflammation.
Moreover,
inducing
expression,
such
as
GPX4,
vivo
can
regulate
microenvironment
immunity
gut
microbiota
attenuate
radiation‐induced
by
oxidative
stress
maintaining
homeostasis.
Together,
these
results
unravel
a
previously
unidentified
modulation
role
but
suppressing
cGAS‐STING‐TBK1‐IRF3
cascade.
iScience,
Год журнала:
2024,
Номер
27(9), С. 110710 - 110710
Опубликована: Авг. 13, 2024
Mitochondria
play
important
roles
in
cell
fate,
calcium
signaling,
mitophagy,
and
the
signaling
through
reactive
oxygen
species
(ROS).
Recently,
mitochondria
are
considered
as
a
organelle
communicate
with
other
organelles
to
constitute
mitochondrial
information
processing
system
(MIPS)
that
transduce
input-to-output
biological
information.
The
success
immunotherapy,
concept
of
systemic
therapy,
has
been
proved
be
dependent
on
paracrine
interactions
within
tumor
microenvironment
(TME)
distant
organs
including
microbiota
immune
components.
We
will
adopt
broader
view
from
TME
micro-
macroenvironment
(T
Globally,
people
widely
recognize
cancer
as
one
of
the
most
lethal
diseases
due
to
its
high
mortality
rates
and
lack
effective
treatment
options.
Ongoing
research
into
therapies
remains
a
critical
area
inquiry,
holding
significant
social
relevance.
Currently
used
treatment,
such
chemotherapy,
radiation,
or
surgery,
often
suffers
from
other
problems
like
damaging
side
effects,
inaccuracy,
ability
clear
tumors.
Conventional
are
usually
imprecise
ineffective
develop
resistance
treatments
recurs.
Cancer
patients
need
fresh
innovative
that
can
reduce
effects
while
maximizing
effectiveness.
In
recent
decades
several
breakthroughs
in
these,
areas
medical
research,
have
paved
way
for
new
avenues
fighting
including
more
focused
alternatives.
This
study
reviews
exciting
possibilities
mesenchymal
stem
cells
(MSCs),
nanomaterials,
microbial
agents
modern
realm
treatment.
Nanoparticles
(NPs)
demonstrated
surprisingly
potential.
They
improve
drug
delivery
systems
(DDS)
significantly,
enhance
imaging
techniques
remarkably,
target
selectively
protecting
healthy
tissues.
MSCs
play
double
role
tissue
repair
vehicle
novel
gene
NPs
loaded
with
therapeutic
agents.
Additionally,
utilizing
agents,
particularly
those
involving
bacteria,
offer
an
inventive
approach
review
investigates
potential
MSCs,
addressing
shortcomings
conventional
therapies.
We
will
also
discuss
challenges
limitations
using
these
approaches.
Pharmacological Research,
Год журнала:
2025,
Номер
213, С. 107636 - 107636
Опубликована: Фев. 1, 2025
FOLFOX
(5-Fluorouracil,
Calcium
Folinate
combined
with
Oxaliplatin)
is
a
preferred
chemotherapy
regimen
for
colon
cancer,
but
its
limited
efficacy
remains
major
challenge,
significantly
impairs
patient
outcomes.
There
an
urgent
need
to
identify
strategies
improve
therapeutic
effectiveness.
Our
previous
studies
have
suggested
that
gut
microbiota-derived
bile
acids
may
be
involved
in
the
anticancer
effect
of
vitro,
however,
underlying
mechanism
unclear.
In
this
study,
we
investigated
role
modulating
and
related
mechanisms.
We
first
demonstrated
depletion
(cholestyramine
treatment)
enhanced
orthotopic
cancer
mouse
model,
suggesting
play
key
FOLFOX's
effects.
Further,
based
on
system
screen
15
via
MTT,
colony
formation
flow
cytometry
assay,
Deoxycholic
Acid
(DCA)
Glycodeoxycholic
(GDCA)
were
annotated
as
potential
modulators
efficacy.
Among
these,
DCA
was
further
validated
enhance
anti-colon
effects
vivo.
Transcriptomic
analysis
subsequent
biological
experiments
revealed
Ugt1a6b.
conclusion,
our
findings
establish
enhances
potentially
Ugt1a6b
mediated
enterohepatic
circulation,
providing
novel
insights
into
synergistic
strategy
improving
treatment.
