Editorial: Neural circuits underlying general anesthetics mediated consciousness changes DOI Creative Commons
Cheng Zhou

Frontiers in Neural Circuits, Год журнала: 2023, Номер 17

Опубликована: Сен. 4, 2023

EDITORIAL article Front. Neural Circuits, 04 September 2023 Volume 17 - | https://doi.org/10.3389/fncir.2023.1251970

A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia DOI Creative Commons
Tingting Yi, Na Wang, Jing Huang

и другие.

Advanced Science, Год журнала: 2023, Номер 10(15)

Опубликована: Март 24, 2023

Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, precise mechanisms underlying its anesthetic action are still not completely understood. Here authors show that sevoflurane activates cluster of urocortin 1 (UCN1

Язык: Английский

Процитировано

19

A potentiation of REM sleep-active neurons in the lateral habenula may be responsible for the sleep disturbance in depression DOI

Zehui Zhang,

Wei Zhang,

Yuanyuan Fang

и другие.

Current Biology, Год журнала: 2024, Номер 34(15), С. 3287 - 3300.e6

Опубликована: Июнь 28, 2024

Язык: Английский

Процитировано

6

Comparative brain-wide mapping of ketamine- and isoflurane-activated nuclei and functional networks in the mouse brain DOI Creative Commons
Yue Hu, Wenjie Du,

Jiangtao Qi

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Июль 3, 2023

Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of the effects KET ISO on c-Fos expression across mouse brain, utilizing hierarchical clustering c-Fos-based functional network to evaluate responses individual brain regions each anesthetic. Our findings reveal that activates wide range regions, notably in cortical subcortical nuclei involved sensory, motor, emotional, reward processing, with temporal association areas (TEa) as strong hub, suggesting top-down mechanism affecting consciousness by primarily targeting higher order networks. contrast, predominantly influences hypothalamus, impacting neuroendocrine control, autonomic function, homeostasis, locus coeruleus (LC) connector indicating bottom-up anesthetic-induced unconsciousness. both activate sensory memory cognition, motivation, well homeostatic highlighting various neural pathways. conclusion, our results highlight but overlapping ISO, enriching understanding underlying anesthesia.

Язык: Английский

Процитировано

11

Ventral pallidum GABAergic and glutamatergic neurons modulate arousal during sevoflurane general anaesthesia in male mice DOI
Bingqian Fan, Junming Xia,

Xiu‐Wen Yi

и другие.

British Journal of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Background and Purpose The induction emergence of general anaesthesia involve an altered process states consciousness, yet the central nervous system mechanisms remain inadequately understood. ventral pallidum (VP) within basal ganglia is crucial in sleep–wake modulation. However, its involvement underlying neuronal are not well elucidated. Experimental Approach In vivo electrophysiological recordings were conducted to examine changes activity different types VP neurons before after sevoflurane exposure. Fibre photometry, combined with electroencephalogram electromyography recordings, was employed analyse during both recovery phases anaesthesia. Chemogenetics implemented investigate impact modulated on emergence, whereas optogenetics used for real time activation at depths Key Results Sevoflurane exposure reduced firing GABAergic (VP GABA ) glutamatergic glu neurons, without affecting cholinergic neurons. decreased increased emergence. Manipulation bidirectionally influenced duration Inhibiting accelerated induction. Real triggered cortical behavioural steady‐state burst suppression ratio deep Conclusion Implications These findings highlight role modulating transitions between stages, providing valuable insights into sevoflurane‐induced

Язык: Английский

Процитировано

0

Propofol Promotes Anesthesia Through the Activation of Centrally-Projecting Edinger–Westphal Nucleus Urocortin 1-Positive Neurons DOI

Jing Huei Huang,

Yiwen Hu,

Sheng Jing

и другие.

Neuroscience Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Язык: Английский

Процитировано

0

Activation of CaMKII+ neurons in the paramedian raphe nucleus promotes general anesthesia in male mice DOI Creative Commons
Xuehan Li, Zhixiong Ma, Xueliang Liu

и другие.

Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)

Опубликована: Май 13, 2025

Язык: Английский

Процитировано

0

Comparative Brain-Wide Mapping of Isoflurane and Ketamine-Activated Nuclei and Functional Networks DOI Open Access
Yue Hu,

Jiangtao Qi,

Zhao Zhang

и другие.

Опубликована: Янв. 10, 2024

Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of KET ISO effects on c-Fos expression across the brain, utilizing hierarchical clustering c-Fos-based functional network to evaluate responses individual brain regions each anesthetic. Our findings demonstrate that significantly activates cortical subcortical arousal-promoting nuclei, with temporal association areas (TEa) serving as hub node, corroborating top-down anesthesia theory for dissociative anesthesia. contrast, nuclei in hypothalamus brainstem, locus coeruleus (LC) implying bottom-up mechanism anesthetic-induced unconsciousness. Notably, coactivation arousal-related analgesia-related, neuroendocrine-related (e.g., prelimbic area (PL) infralimbic (ILA), anterior paraventricular nucleus (aPVT), Edinger-Westphal (EW), (LC), parabrachial (PB), solitary tract (NTS) by both anesthetics underscores features such unconsciousness, analgesia, autonomic regulation, irrespective specific molecular targets. conclusion, our results emphasize actions while also uncovering commonly activated regions, thus contributing advancement understanding underlying

Язык: Английский

Процитировано

2

Melatonin targets the paraventricular thalamus to promote non-rapid eye movement sleep in C3H/HeJ mice DOI

Yaling Wang,

Zhenbo Song,

Han Qi

и другие.

Current Biology, Год журнала: 2024, Номер 34(16), С. 3792 - 3803.e5

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

2

Isolated theta waves originating from the midline thalamus trigger memory reactivation during NREM sleep in mice DOI Creative Commons
Qin Xiao, Minmin Lu, Xiaolong Zhang

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 25, 2024

Язык: Английский

Процитировано

1

Comparative Brain-Wide Mapping of Ketamine and Isoflurane-Activated Nuclei and Functional Networks DOI Creative Commons
Yue Hu, Wenjie Du,

Jiangtao Qi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 6, 2023

Abstract Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of the effects KET ISO on c-Fos expression across brain, utilizing hierarchical clustering c-Fos-based functional network to evaluate responses individual brain regions each anesthetic. Our findings reveal that activates wide range regions, notably in cortical subcortical nuclei involved sensory, motor, emotional, reward processing, with temporal association areas (TEa) as strong hub, suggesting top-down mechanism affecting consciousness by primarily targeting higher-order networks. contrast, predominantly influences hypothalamus, impacting neuroendocrine control, autonomic function, homeostasis, locus coeruleus (LC) connector indicating bottom-up anesthetic-induced unconsciousness. both activate sensory memory cognition, motivation, well homeostatic highlighting various neural pathways. conclusion, our results highlight but overlapping ISO, enriching understanding underlying anesthesia.

Язык: Английский

Процитировано

1