
Frontiers in Neural Circuits, Год журнала: 2023, Номер 17
Опубликована: Сен. 4, 2023
EDITORIAL article Front. Neural Circuits, 04 September 2023 Volume 17 - | https://doi.org/10.3389/fncir.2023.1251970
Frontiers in Neural Circuits, Год журнала: 2023, Номер 17
Опубликована: Сен. 4, 2023
EDITORIAL article Front. Neural Circuits, 04 September 2023 Volume 17 - | https://doi.org/10.3389/fncir.2023.1251970
Advanced Science, Год журнала: 2023, Номер 10(15)
Опубликована: Март 24, 2023
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, precise mechanisms underlying its anesthetic action are still not completely understood. Here authors show that sevoflurane activates cluster of urocortin 1 (UCN1
Язык: Английский
Процитировано
19Current Biology, Год журнала: 2024, Номер 34(15), С. 3287 - 3300.e6
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
6eLife, Год журнала: 2023, Номер 12
Опубликована: Июль 3, 2023
Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of the effects KET ISO on c-Fos expression across mouse brain, utilizing hierarchical clustering c-Fos-based functional network to evaluate responses individual brain regions each anesthetic. Our findings reveal that activates wide range regions, notably in cortical subcortical nuclei involved sensory, motor, emotional, reward processing, with temporal association areas (TEa) as strong hub, suggesting top-down mechanism affecting consciousness by primarily targeting higher order networks. contrast, predominantly influences hypothalamus, impacting neuroendocrine control, autonomic function, homeostasis, locus coeruleus (LC) connector indicating bottom-up anesthetic-induced unconsciousness. both activate sensory memory cognition, motivation, well homeostatic highlighting various neural pathways. conclusion, our results highlight but overlapping ISO, enriching understanding underlying anesthesia.
Язык: Английский
Процитировано
11British Journal of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Abstract Background and Purpose The induction emergence of general anaesthesia involve an altered process states consciousness, yet the central nervous system mechanisms remain inadequately understood. ventral pallidum (VP) within basal ganglia is crucial in sleep–wake modulation. However, its involvement underlying neuronal are not well elucidated. Experimental Approach In vivo electrophysiological recordings were conducted to examine changes activity different types VP neurons before after sevoflurane exposure. Fibre photometry, combined with electroencephalogram electromyography recordings, was employed analyse during both recovery phases anaesthesia. Chemogenetics implemented investigate impact modulated on emergence, whereas optogenetics used for real time activation at depths Key Results Sevoflurane exposure reduced firing GABAergic (VP GABA ) glutamatergic glu neurons, without affecting cholinergic neurons. decreased increased emergence. Manipulation bidirectionally influenced duration Inhibiting accelerated induction. Real triggered cortical behavioural steady‐state burst suppression ratio deep Conclusion Implications These findings highlight role modulating transitions between stages, providing valuable insights into sevoflurane‐induced
Язык: Английский
Процитировано
0Neuroscience Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Язык: Английский
Процитировано
0Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)
Опубликована: Май 13, 2025
Язык: Английский
Процитировано
0Опубликована: Янв. 10, 2024
Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of KET ISO effects on c-Fos expression across the brain, utilizing hierarchical clustering c-Fos-based functional network to evaluate responses individual brain regions each anesthetic. Our findings demonstrate that significantly activates cortical subcortical arousal-promoting nuclei, with temporal association areas (TEa) serving as hub node, corroborating top-down anesthesia theory for dissociative anesthesia. contrast, nuclei in hypothalamus brainstem, locus coeruleus (LC) implying bottom-up mechanism anesthetic-induced unconsciousness. Notably, coactivation arousal-related analgesia-related, neuroendocrine-related (e.g., prelimbic area (PL) infralimbic (ILA), anterior paraventricular nucleus (aPVT), Edinger-Westphal (EW), (LC), parabrachial (PB), solitary tract (NTS) by both anesthetics underscores features such unconsciousness, analgesia, autonomic regulation, irrespective specific molecular targets. conclusion, our results emphasize actions while also uncovering commonly activated regions, thus contributing advancement understanding underlying
Язык: Английский
Процитировано
2Current Biology, Год журнала: 2024, Номер 34(16), С. 3792 - 3803.e5
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
2Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
1bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июнь 6, 2023
Abstract Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of the effects KET ISO on c-Fos expression across brain, utilizing hierarchical clustering c-Fos-based functional network to evaluate responses individual brain regions each anesthetic. Our findings reveal that activates wide range regions, notably in cortical subcortical nuclei involved sensory, motor, emotional, reward processing, with temporal association areas (TEa) as strong hub, suggesting top-down mechanism affecting consciousness by primarily targeting higher-order networks. contrast, predominantly influences hypothalamus, impacting neuroendocrine control, autonomic function, homeostasis, locus coeruleus (LC) connector indicating bottom-up anesthetic-induced unconsciousness. both activate sensory memory cognition, motivation, well homeostatic highlighting various neural pathways. conclusion, our results highlight but overlapping ISO, enriching understanding underlying anesthesia.
Язык: Английский
Процитировано
1