ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(10), С. 5737 - 5746
Опубликована: Сен. 21, 2023
Inflammatory
bowel
disease
(IBD)
is
a
frequently
occurring
that
seriously
influences
the
patient's
quality
of
life.
To
decrease
adverse
effects
and
improve
efficacy
therapeutics,
nanomedicines
have
been
widely
used
to
treat
IBD.
However,
how
thoroughly
release
payloads
under
an
inflammatory
microenvironment
synergistic
therapy
IBD
need
be
further
investigated.
address
this
issue,
cyclosporine
A
(CsA)-loaded,
folic
acid
(FA)-modified,
pH
reactive
oxygen
species
(ROS)
dual-responsive
nanoparticles
(FA-CsA
NPs)
were
fabricated
using
pH/ROS-responsive
material
as
carrier.
The
prepared
FA-CsA
NPs
had
spherical
shape
uniform
size
distribution
could
smartly
their
and/or
ROS
microenvironment.
In
vitro
experiments
demonstrated
can
effectively
internalized
by
activated
macrophages,
down-regulate
expression
proinflammatory
cytokines
compared
free
drug
or
nontargeted
NPs.
vivo
verified
significantly
accumulated
at
colon
tissues
obviously
improved
symptoms
colitis
in
mice
without
obvious
effects.
conclusion,
our
results
provided
candidate
for
targeted
treatment
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(3)
Опубликована: Дек. 5, 2023
This
work
reports
that
a
low-temperature
thermal
calcination
strategy
was
adopted
to
modulate
the
electronic
structure
and
attain
an
abundance
of
surface-active
sites
while
maintaining
crystal
morphology.
All
experiments
demonstrate
new
photocatalyst
nano
MIL-125(Ti)-250
obtained
by
has
abundant
Ti
Overexpression
of
classically
activated
macrophages
(M1)
subtypes
and
assessed
reactive
oxygen
species
(ROS)
levels
are
often
observed
in
patients
with
ulcerative
colitis.
At
present,
the
treatment
system
these
two
problems
has
yet
to
be
established.
Here,
chemotherapy
drug
curcumin
(CCM)
is
decorated
Prussian
blue
analogs
a
straightforward
cost-saving
manner.
Modified
CCM
can
released
inflammatory
tissue
(acidic
environment),
eventually
causing
M1
transform
into
M2
inhibiting
pro-inflammatory
factors.
Co(III)
Fe(II)
have
abundant
valence
variations,
lower
REDOX
potential
CCM-CoFe
PBA
enables
ROS
clearance
through
multi-nanomase
activity.
In
addition,
effectively
alleviated
symptoms
UC
mice
induced
by
DSS
inhibited
progression
disease.
Therefore,
present
material
may
used
as
new
therapeutic
agent
for
UC.
Angewandte Chemie,
Год журнала:
2023,
Номер
136(3)
Опубликована: Дек. 5, 2023
Abstract
This
work
reports
that
a
low‐temperature
thermal
calcination
strategy
was
adopted
to
modulate
the
electronic
structure
and
attain
an
abundance
of
surface‐active
sites
while
maintaining
crystal
morphology.
All
experiments
demonstrate
new
photocatalyst
nano
MIL‐125(Ti)‐250
obtained
by
has
abundant
Ti
3+
induced
oxygen
vacancies
high
specific
surface
area.
facilitates
adsorption
activation
N
2
molecules
on
active
in
photocatalytic
nitrogen
fixation.
The
NH
3
yield
over
is
enhanced
156.9
μmol
g
−1
h
,
twice
higher
than
parent
MIL‐125(Ti)
(76.2
).
Combined
with
density
function
theory
(DFT),
it
shows
pattern
tends
be
from
“end‐on”
“side‐on”
mode,
which
thermodynamically
favourable.
Moreover,
electrochemical
tests
atomic
ratio
/Ti
4+
can
enhance
carrier
separation,
also
promotes
efficiency
may
offer
insights
into
design
innovative
photocatalysts
for
various
chemical
reduction
reactions.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 167 - 180
Опубликована: Янв. 28, 2024
Reactive
oxygen
species
(ROS),
immune
dysregulation-induced
inflammatory
outbreaks
and
microbial
imbalance
play
critical
roles
in
the
development
of
bowel
disease
(IBD).
Herein,
a
novel
enzyme-like
biomimetic
oral-agent
ZnPBA@YCW
has
been
developed,
using
yeast
cell
wall
(YCW)
as
outer
shell
zinc-doped
Prussian
blue
analogue
(ZnPBA)
nanozyme
inside.
When
orally
administered,
is
able
to
adhere
ACS Nano,
Год журнала:
2024,
Номер
18(15), С. 10625 - 10641
Опубликована: Апрель 2, 2024
Development
of
nanomedicines
that
can
collaboratively
scavenge
reactive
oxygen
species
(ROS)
and
inhibit
inflammatory
cytokines,
along
with
osteogenesis
promotion,
is
essential
for
efficient
osteoarthritis
(OA)
treatment.
Herein,
we
report
the
design
a
ROS-responsive
nanomedicine
formulation
based
on
fibronectin
(FN)-coated
polymer
nanoparticles
(NPs)
loaded
azabisdimethylphoaphonate-terminated
phosphorus
dendrimers
(G4-TBP).
The
constructed
G4-TBP
NPs-FN
size
268
nm
are
stable
under
physiological
conditions,
be
specifically
taken
up
by
macrophages
through
FN-mediated
targeting,
dissociated
in
oxidative
microenvironment.
dendrimer
having
intrinsic
anti-inflammatory
property
FN
both
antioxidative
properties
display
integrated
functions
ROS
scavenging,
hypoxia
attenuation,
macrophage
M2
polarization,
thus
protecting
from
apoptosis
creating
designed
bone
immune
microenvironment
stem
cell
osteogenic
differentiation.
These
characteristics
lead
to
their
effective
treatment
an
OA
model
vivo
reduce
pathological
changes
joints
including
synovitis
inhibition
cartilage
matrix
degradation
simultaneously
promote
differentiation
repair.
developed
combining
advantages
bioactive
treat
may
immunomodulatory
therapy
different
diseases.
Abstract
Accumulation
of
reactive
oxygen
species
(ROS)
in
periodontitis
exacerbates
the
destruction
alveolar
bone.
Therefore,
scavenging
ROS
to
reshape
periodontal
microenvironment,
alleviate
inflammatory
response
and
promote
endogenous
stem
cell
osteogenic
differentiation
may
be
an
effective
strategy
for
treating
bone
resorption
periodontitis.
In
this
study,
sericin‐hydroxyapatite
nanoparticles
(Se‐nHA
NPs)
are
synthesized
using
a
biomimetic
mineralization
method.
Se‐nHA
NPs
proanthocyanidins
(PC)
then
encapsulated
sericin/sodium
alginate
(Se/SA)
electrostatic
injection
technique
prepare
Se‐nHA/PC
microspheres.
Microspheres
ROS,
inhibiting
polarization
macrophages
toward
M1
type,
inducing
M2
type.
normal
or
macrophage‐conditioned
media,
microspheres
effectively
promoted
human
ligament
cells
(hPDLSCs).
Furthermore,
demonstrated
anti‐inflammatory
effects
rat
model
by
suppressing
pro‐inflammatory
cytokines.
The
also
distinguished
their
capacity
decrease
loss,
reduce
osteoclast
activity,
boost
factor
expression.
composite
have
efficient
ROS‐scavenging,
anti‐inflammatory,
abilities
can
used
as
multifunctional
filling
material
tissue
regeneration.
Advanced Materials,
Год журнала:
2023,
Номер
36(14)
Опубликована: Дек. 13, 2023
The
treatment
outcomes
of
oral
medications
against
ulcerative
colitis
(UC)
have
long
been
restricted
by
low
drug
accumulation
in
the
mucosa
and
subsequent
unsatisfactory
therapeutic
efficacy.
Here,
high-performance
pluronic
F127
(P127)-modified
gold
shell
(AuS)-polymeric
core
nanotherapeutics
loading
with
curcumin
(CUR)
is
constructed.
Under
near-infrared
irradiation,
resultant
P127-AuS@CURs
generate
transient
mild
photothermia
(TMP;
≈42
°C,
10
min),
which
facilitates
their
penetration
through
colonic
mucus
favors
multiple
cellular
processes,
including
cell
internalization,
lysosomal
escape,
controlled
CUR
release.
This
strategy
relieves
intracellular
oxidative
stress,
improves
wound
healing,
reduces
immune
responses
polarizing
proinflammatory
M1-type
macrophages
to
anti-inflammatory
M2-type.
Upon
administration
hydrogel-encapsulating
plus
intestinal
intralumen
TMP,
effects
acute
chronic
UC
are
demonstrated
be
superior
those
a
widely
used
clinical
drug,
dexamethasone.
(+
TMP)
elevates
proportions
beneficial
bacteria
(e.g.,
Lactobacillus
Lachnospiraceae),
whose
metabolites
can
also
mitigate
symptoms
regulating
genes
associated
antioxidation,
anti-inflammation,
healing.
Overall,
TMP
offers
promising
approach
enhance
noninvasive
medicines
UC.
