Synergistic Effect of Oxygen Vacancy and High Porosity of Nano MIL‐125(Ti) for Enhanced Photocatalytic Nitrogen Fixation

Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(3)

Опубликована: Дек. 5, 2023

This work reports that a low-temperature thermal calcination strategy was adopted to modulate the electronic structure and attain an abundance of surface-active sites while maintaining crystal morphology. All experiments demonstrate new photocatalyst nano MIL-125(Ti)-250 obtained by has abundant Ti

Язык: Английский

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A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment

Advanced Science, Год журнала: 2023, Номер 10(19)

Опубликована: Май 17, 2023

Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system these two problems has yet to be established. Here, chemotherapy drug curcumin (CCM) is decorated Prussian blue analogs a straightforward cost-saving manner. Modified CCM can released inflammatory tissue (acidic environment), eventually causing M1 transform into M2 inhibiting pro-inflammatory factors. Co(III) Fe(II) have abundant valence variations, lower REDOX potential CCM-CoFe PBA enables ROS clearance through multi-nanomase activity. In addition, effectively alleviated symptoms UC mice induced by DSS inhibited progression disease. Therefore, present material may used as new therapeutic agent for UC.

Язык: Английский

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Synergistic Effect of Oxygen Vacancy and High Porosity of Nano MIL‐125(Ti) for Enhanced Photocatalytic Nitrogen Fixation

Angewandte Chemie, Год журнала: 2023, Номер 136(3)

Опубликована: Дек. 5, 2023

Abstract This work reports that a low‐temperature thermal calcination strategy was adopted to modulate the electronic structure and attain an abundance of surface‐active sites while maintaining crystal morphology. All experiments demonstrate new photocatalyst nano MIL‐125(Ti)‐250 obtained by has abundant Ti 3+ induced oxygen vacancies high specific surface area. facilitates adsorption activation N 2 molecules on active in photocatalytic nitrogen fixation. The NH 3 yield over is enhanced 156.9 μmol g −1 h , twice higher than parent MIL‐125(Ti) (76.2 ). Combined with density function theory (DFT), it shows pattern tends be from “end‐on” “side‐on” mode, which thermodynamically favourable. Moreover, electrochemical tests atomic ratio /Ti 4+ can enhance carrier separation, also promotes efficiency may offer insights into design innovative photocatalysts for various chemical reduction reactions.

Язык: Английский

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Nanomaterials Derived from Metal–Organic Frameworks and Their Applications for Pollutants Removal

Reviews of Environmental Contamination and Toxicology, Год журнала: 2024, Номер 262(1)

Опубликована: Май 17, 2024

Язык: Английский

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Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease

Bioactive Materials, Год журнала: 2024, Номер 35, С. 167 - 180

Опубликована: Янв. 28, 2024

Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks and microbial imbalance play critical roles in the development of bowel disease (IBD). Herein, a novel enzyme-like biomimetic oral-agent ZnPBA@YCW has been developed, using yeast cell wall (YCW) as outer shell zinc-doped Prussian blue analogue (ZnPBA) nanozyme inside. When orally administered, is able to adhere

Язык: Английский

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A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 740 - 755

Опубликована: Март 19, 2024

Язык: Английский

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Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis

ACS Nano, Год журнала: 2024, Номер 18(15), С. 10625 - 10641

Опубликована: Апрель 2, 2024

Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.

Язык: Английский

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A Biomimetic Se‐nHA/PC Composite Microsphere with Synergistic Immunomodulatory and Osteogenic Ability to Activate Bone Regeneration in Periodontitis

Small, Год журнала: 2023, Номер 20(9)

Опубликована: Окт. 18, 2023

Abstract Accumulation of reactive oxygen species (ROS) in periodontitis exacerbates the destruction alveolar bone. Therefore, scavenging ROS to reshape periodontal microenvironment, alleviate inflammatory response and promote endogenous stem cell osteogenic differentiation may be an effective strategy for treating bone resorption periodontitis. In this study, sericin‐hydroxyapatite nanoparticles (Se‐nHA NPs) are synthesized using a biomimetic mineralization method. Se‐nHA NPs proanthocyanidins (PC) then encapsulated sericin/sodium alginate (Se/SA) electrostatic injection technique prepare Se‐nHA/PC microspheres. Microspheres ROS, inhibiting polarization macrophages toward M1 type, inducing M2 type. normal or macrophage‐conditioned media, microspheres effectively promoted human ligament cells (hPDLSCs). Furthermore, demonstrated anti‐inflammatory effects rat model by suppressing pro‐inflammatory cytokines. The also distinguished their capacity decrease loss, reduce osteoclast activity, boost factor expression. composite have efficient ROS‐scavenging, anti‐inflammatory, abilities can used as multifunctional filling material tissue regeneration.

Язык: Английский

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Transient Mild Photothermia Improves Therapeutic Performance of Oral Nanomedicines with Enhanced Accumulation in the Colitis Mucosa

Advanced Materials, Год журнала: 2023, Номер 36(14)

Опубликована: Дек. 13, 2023

The treatment outcomes of oral medications against ulcerative colitis (UC) have long been restricted by low drug accumulation in the mucosa and subsequent unsatisfactory therapeutic efficacy. Here, high-performance pluronic F127 (P127)-modified gold shell (AuS)-polymeric core nanotherapeutics loading with curcumin (CUR) is constructed. Under near-infrared irradiation, resultant P127-AuS@CURs generate transient mild photothermia (TMP; ≈42 °C, 10 min), which facilitates their penetration through colonic mucus favors multiple cellular processes, including cell internalization, lysosomal escape, controlled CUR release. This strategy relieves intracellular oxidative stress, improves wound healing, reduces immune responses polarizing proinflammatory M1-type macrophages to anti-inflammatory M2-type. Upon administration hydrogel-encapsulating plus intestinal intralumen TMP, effects acute chronic UC are demonstrated be superior those a widely used clinical drug, dexamethasone. (+ TMP) elevates proportions beneficial bacteria (e.g., Lactobacillus Lachnospiraceae), whose metabolites can also mitigate symptoms regulating genes associated antioxidation, anti-inflammation, healing. Overall, TMP offers promising approach enhance noninvasive medicines UC.

Язык: Английский

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Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 15, 2024

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have been engineered monitor macrophage metabolism, enabling evaluation of progression and replication intricate physiological signal patterns. They achieve this either directly or by delivering regulatory signals, thereby mapping phenotype effector functions through metabolic repurposing customize fate for therapy. However, a comprehensive summary regarding NM-mediated visualization coordinated rewiring maintain phenotypic equilibrium is currently lacking. This review aims address gap outlining recent advancements in NM-based immunotherapy. We initially explore relationship between polarization, disease, before delving into NM innovations that visualize activity elucidate onset fine-tune its remodeling macrophage-centered Finally, we discuss prospects challenges immunotherapy, aiming accelerate clinical translation. anticipate will serve as valuable reference researchers seeking leverage novel intervention-matched immunomodulators macrophages other fields engineering.

Язык: Английский

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