Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Lung
cancer
has
high
metastasis
and
drug
resistance.
The
prognosis
of
lung
patients
is
poor
the
patients’
survival
chances
are
easily
neglected.
Ferroptosis
a
programmed
cell
death
proposed
in
2012,
which
differs
from
apoptosis,
necrosis
autophagy.
novel
type
regulated
driven
by
iron-dependent
lipid
peroxidation
subsequent
plasma
membrane
ruptures.
It
broad
prospects
field
tumor
disease
treatment.
At
present,
multiple
studies
have
shown
that
biological
compounds
can
induce
ferroptosis
cells,
exhibits
significant
anti-cancer
effects,
they
advantages
safety,
minimal
side
less
possibility
to
In
this
review,
we
summarize
used
for
treatment
focusing
on
its
mechanism.
addition,
systematically
review
current
research
status
combining
nanotechnology
with
treatment,
shed
new
light
targeting
pathways
applying
compounds-based
therapies.
Metal-organic
framework
(MOF)-based
drug
delivery
systems
have
demonstrated
values
in
oncotherapy.
Current
research
endeavors
are
centralized
on
the
functionality
enrichment
of
featured
MOF
materials
with
designed
versatility
for
synergistic
multimodal
treatments.
Here,
inspired
by
multifarious
biological
functions
including
ferroptosis
pattern,
porphyrins,
and
cancer
cell
membrane
(CCM)
camouflage
technique,
novel
multi-biomimetic
nanocarriers
from
microfluidics
prepared.
The
Fe
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Фев. 15, 2024
Abstract
High‐performance
theranostic
systems
are
of
paramount
importance
for
achieving
precise
image‐guided
cancer
immunotherapy.
Here,
a
novel
nanoplatform
is
presented
that
integrates
aggregation‐induced
emission
luminogen
(AIEgen)
with
prussian
blue
(PB)
nanocatalyzer
robust
The
AIEgen
dimethylamine
substitution
demonstrates
compelling
near‐infrared
(NIR)
light‐induced
photothermal
conversion
and
photodynamic
therapy
(PDT)
capabilities.
By
incorporating
into
porous
PBNPs,
further
enveloped
within
M1
macrophage
membrane,
tumor‐specific
nanoagent
constructed.
This
strategic
integration
effectively
constrains
the
molecular
motion
AIEgen,
leading
to
amplified
NIR‐II
fluorescence
brightness
PDT
attributes.
Moreover,
PBNPs
can
catalyze
tumor‐overexpressed
H
2
O
generate
oxygen
boost
efficacy,
PB's
NIR
absorption
also
intensifies
photoacoustic
imaging
effect.
provides
comprehensive
information
photoimmunotherapy
in
orthotopic
breast
cancer‐bearing
mice.
Leveraging
its
potent
immunogenic
cell
death
effect,
not
only
significantly
inhibits
growth,
but
generates
whole‐cell
therapeutic
vaccine
protect
mice
from
tumor
rechallenge.
In
highly
malignant
post‐surgery
models,
enables
both
accurate
identification
residual
tumors
efficient
inhibition
postoperative
recurrence
pulmonary
metastasis.
study
will
offer
valuable
insights
creating
efficacious
multifaceted
protocols.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июнь 17, 2024
Abstract
Microgels
prepared
from
natural
or
synthetic
hydrogel
materials
have
aroused
extensive
attention
as
multifunctional
cells
drug
carriers,
that
are
promising
for
tissue
engineering
and
regenerative
medicine.
can
also
be
aggregated
into
microporous
scaffolds,
promoting
cell
infiltration
proliferation
repair.
This
review
gives
an
overview
of
recent
developments
in
the
fabrication
techniques
applications
microgels.
A
series
conventional
novel
strategies
including
emulsification,
microfluidic,
lithography,
electrospray,
centrifugation,
gas-shearing,
three-dimensional
bioprinting,
etc.
discussed
depth.
The
characteristics
microgels
microgel-based
scaffolds
culture
delivery
elaborated
with
emphasis
on
advantages
these
carriers
therapy.
Additionally,
we
expound
ongoing
foreseeable
current
limitations
their
aggregate
field
biomedical
engineering.
Through
stimulating
innovative
ideas,
present
paves
new
avenues
expanding
application
techniques.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Abstract
Microfluidic
droplets,
with
their
unique
properties
and
broad
applications,
are
essential
in
chemical,
biological,
materials
synthesis
research.
Despite
the
flourishing
studies
on
artificial
intelligence‐accelerated
microfluidics,
most
research
efforts
have
focused
upstream
design
phase
of
microfluidic
systems.
Generating
user‐desired
droplets
still
remains
laborious,
inefficient,
time‐consuming.
To
address
long‐standing
challenges
associated
accurate
efficient
identification,
sorting,
analysis
morphology
generation
rate
single
double
emulsion
a
novel
machine
vision
approach
utilizing
deformable
detection
transformer
(DETR)
algorithm
is
proposed.
This
method
enables
rapid
precise
(detection
relative
error
<
4%
precision
>
94%)
across
various
scales
scenarios,
including
real‐world
simulated
environments.
identification
(MDIA),
web‐based
tool
powered
by
Deformable
DETR,
which
supports
transfer
learning
to
enhance
accuracy
specific
user
scenarios
developed.
MDIA
characterizes
diameter,
number,
frequency,
other
parameters.
As
more
training
data
added
users,
MDIA's
capability
universality
expand,
contributing
comprehensive
database
for
droplet
microfluidics.
The
work
highlights
potential
intelligence
advancing
regulation,
fabrication,
label‐free
analysis,
accelerating
biochemical
sciences
engineering.
The
development
of
non-antibiotic
pharmaceuticals
with
biocompatible
and
efficient
antibacterial
properties
is
great
significance
for
the
treatment
bacterial
keratitis.
In
this
study,
we
have
developed
iron-doped
nanozymes
(Fe
