Polydopamine-Coated Zn-MOF-74 Nanocarriers: Versatile Drug Delivery Systems with Enhanced Biocompatibility and Cancer Therapeutic Efficacy
Journal of Inorganic and Organometallic Polymers and Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 13, 2024
Язык: Английский
Exploring the synthesis, properties, and potential of chitosan-functionalized metal-organic frameworks in emerging applications
Progress in Materials Science,
Год журнала:
2024,
Номер
148, С. 101387 - 101387
Опубликована: Окт. 9, 2024
Язык: Английский
Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics
Hybrid Advances,
Год журнала:
2025,
Номер
unknown, С. 100406 - 100406
Опубликована: Фев. 1, 2025
Язык: Английский
Metal–Organic Frameworks: Unconventional Nanoweapons against COVID
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(25), С. 32118 - 32127
Опубликована: Июнь 11, 2024
The
SARS-CoV-2
(COVID-19)
pandemic
outbreak
led
to
enormous
social
and
economic
repercussions
worldwide,
felt
even
this
date,
making
the
design
of
new
therapies
combat
fast-spreading
viruses
an
imperative
task.
In
face
this,
diverse
cutting-edge
nanotechnologies
have
risen
as
promising
tools
treat
infectious
diseases
such
COVID-19,
well
challenging
illnesses
cancer
diabetes.
Aside
from
these
applications,
nanoscale
metal-organic
frameworks
(nanoMOFs)
attracted
much
attention
novel
efficient
drug
delivery
systems
for
pathologies.
However,
their
potential
anti-COVID-19
therapeutic
agents
has
not
been
investigated.
Herein,
we
propose
a
pioneering
anti-COVID
MOF
approach
by
studying
safe
intrinsically
antiviral
through
screening
various
nanoMOF.
iron(III)-trimesate
MIL-100
showed
noteworthy
effect
against
at
micromolar
range,
ensuring
high
biocompatibility
profile
(90%
viability)
in
real
infected
human
cellular
scenario.
This
research
effectively
paves
way
toward
based
on
nanoMOFs,
only
but
also
other
and/or
pulmonary
diseases.
Язык: Английский
Efficacy of a Zn-based metalorganic framework doped with benznidazole on acute experimental Trypanosoma cruzi infection
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 28, 2024
Abstract
Metal-Organic
Frameworks
(MOFs)
have
are
known
to
enhance
the
activity
of
compounds
when
used
as
drug
carriers
due
their
ability
cross
cell
membrane,
allowing
for
controlled
and
selective
release.
In
this
study,
effect
BNZ@Zn-MOFs
on
acute
phase
infection
was
evaluated
in
a
mouse
model.
The
particles
were
obtained
by
electroelution
(EL),
doped
with
BZN
mechanochemistry
characterized
scanning
electron
microscopy
(SEM),
infrared
spectroscopy
(FTIR)
X-ray
diffraction
(XRD).
BNZ@Zn-MOF
released
80%
after
3
h.
No
cytotoxicity
observed
NIH-3T3
HeLa
cells.
Antiparasitic
model
experimental
BALB/c
mice,
using
dose
250
times
lower
than
that
required
free
BZN.
PCR
analysis
showed
no
parasite
DNA
tissues
treated
mice.
Hematoxylin-eosin
staining
revealed
apparent
damage
tissue
architecture.
Serum
levels
liver
function
enzymes
remained
unchanged.
use
suboptimal
doses
delivery
system
allows
maintenance
may
facilitate
significant
reduction
side
effects
caused
administration
treatment
Chagas
disease.
Язык: Английский
Hyaluronic acid modified Cu/Mn-doped metal-organic framework nanocatalyst for chemodynamic therapy
Xiaohuan Guo,
Q. Fang,
Nan Leng
и другие.
Biomedical Materials,
Год журнала:
2024,
Номер
19(6), С. 065025 - 065025
Опубликована: Окт. 2, 2024
Chemodynamic
therapy
(CDT)
is
a
new
method
for
cancer
treatment
that
produces
highly
toxic
reactive
oxygen
species
(ROS)
in
the
tumor
microenvironment
to
induce
cell
apoptosis
or
necrosis.
However,
therapeutic
effect
of
CDT
often
hindered
by
intracellular
H
Язык: Английский
Efficacy of a Zn-based metalorganic framework doped with benznidazole on acute experimental Trypanosoma cruzi infection
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 7, 2024
Язык: Английский
A versatile method for facile and reliable synthesis of colloidal particles with a size and composition gradient
Alexander Berger,
M. Theis,
Henrike von Wedel
и другие.
Colloid & Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Colloidal
particles
play
a
pivotal
role
in
numerous
applications
across
various
disciplines,
many
of
which
necessitate
precise
control
over
particle
size
and
distribution.
Seeded
growth
reactions
have
been
established
as
effective
methods
for
reproducibly
accessing
tailor-made
particles.
However,
conventional
batch-wise
syntheses
only
yield
discrete
sizes.
With
the
increasing
focus
on
complex
structures
current
research,
there
is
demand
innovative
adaptable
techniques
to
produce
colloidal
with
sizes
distributions.
The
Controlled
Emulsion
Extraction
Process
(CrEEP)
capable
addressing
this
challenge.
Here,
we
present
detail
how
synthesis
works
demonstrate
its
reliability
versatility.
Our
approach
exploits
time-dependent
enables
dispersions
controlled
We
highlight
these
possibilities
through
variation
monomer
feed
composition,
resulting
gradual
changes
both
glass
transition
temperature,
respectively.
Beyond
application
polymer
particles,
CrEEP
can
be
seamlessly
extended
other
seeded-growth
mechanisms,
such
silica
Stöber
synthesis.
Consequently,
(CrESP)
similarly
yields
gradient,
showcasing
generality
synthetic
advancement.
Graphical
abstract
Язык: Английский