Journal of Sensor Science and Technology, Год журнала: 2024, Номер 33(6), С. 419 - 428
Опубликована: Ноя. 30, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(13)
Опубликована: Янв. 19, 2024
Abstract Planar microelectrode arrays (MEAs) for – in vitro or vivo neuronal signal recordings lack the spatial resolution and sufficient signal‐to‐noise ratio (SNR) required a detailed understanding of neural network function synaptic plasticity. To overcome these limitations, highly customizable three‐dimensional (3D) printing process is used combination with thin film technology self‐aligned template‐assisted electrochemical deposition to fabricate 3D‐printed‐based MEAs on stiff flexible substrates. Devices design flexibility physical robustness are shown recording activity different applications, achieving high‐aspect 3D microelectrodes up 33:1. Here, successfully record cultures, retinal explants, cortex living mice, thereby demonstrating versatility MEA while maintaining high‐quality recordings. Customizable provide unique opportunities study under regular various pathological conditions, both vivo, contribute development drug screening neuromodulation systems that can accurately monitor large networks over time.
Язык: Английский
Процитировано
16
Med-X, Год журнала: 2025, Номер 3(1)
Опубликована: Фев. 1, 2025
Abstract Organoids have gained significant interest due to their ability recapitulate the structural, molecular, and functional complexity of corresponding organs. While methods been developed characterize benchmark organoid structural molecular properties, capturing development maturation organoids remains challenging. To address this, multifunctional bioelectronics for interfacing with has actively pursued. However, conventional electronics face limitations in achieving recording control across entire three-dimensional (3D) volume a long-term stable manner large morphological cellular composition changes during development. In this review, we first discuss application interfacing. We then focus on flexible stretchable designed create organoid/electronics hybrids chronically interfaces. also review recent advancements charting multimodal cell activities throughout Furthermore, explore integration other characterization modalities comprehensive cells within 3D tissues. Finally, potential integrating artificial intelligence into system through embedded electronics, harnessing biosymbiotic computational systems. These could provide valuable tools characterizing maturation, establishing patient-specific models, developing therapeutic opportunities, exploring novel strategies. Graphical abstract
Язык: Английский
Процитировано
0
Biosensors and Bioelectronics, Год журнала: 2025, Номер 277, С. 117257 - 117257
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Sensors and Actuators A Physical, Год журнала: 2025, Номер unknown, С. 116412 - 116412
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
The Neuroscientist, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Harnessing intelligence from brain cells in vitro requires a multidisciplinary approach integrating wetware, hardware, and software. Wetware comprises the themselves, where differentiation induced pluripotent stem offers ethical scalability; hardware typically involves life support system setup to record activity deliver stimulation cells; software is required control process signals coming going cells. This review provides broad summary of foundational technologies underpinning these components, along with outlining importance technology integration. Of particular that this new ability extend beyond traditional methods assess primarily survival spontaneous neural cultures. Instead, focus returns core function tissue: neurocomputational information respond accordingly. Therefore, also covers work that, despite relatively early state current technology, has provided novel meaningful understandings field neuroscience opening exciting avenues for future research.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
Abstract 3D microelectrode arrays (MEAs) are gaining popularity as brain–machine interfaces and platforms for studying electrophysiological activity. Interactions with neural tissue depend on the electrochemical, mechanical, spatial features of recording platform. While planar or protruding 2D MEAs limited in their ability to capture activity across layers, existing still require advancements manufacturing scalability, resolution, integration. In this work, a customizable, scalable, straightforward approach fabricate flexible kirigami containing both surface penetrating electrodes, designed interact space tissue, is presented. These novel probes feature up 512 electrodes distributed 128 shanks single device, shank heights reaching 1 mm. The successfully deployed several applications, vitro vivo, identified spatially dependent patterns. Flexible therefore powerful tool large‐scale electrical sampling complex tissues while improving integration offering enhanced capabilities analyzing disorders disease models where high resolution required.
Язык: Английский
Процитировано
0
Advanced Electronic Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
Abstract The development of high‐density microelectrode arrays (MEAs) for large‐scale brain recordings requires neural probes with reduced footprints to minimize tissue damage. One way achieve this is by implementing dense electrode narrower feedline dimensions, though increases susceptibility capacitive coupling between electrical interconnects. To address this, study explores the resolution limits flexible MEAs optimizing fabrication using optical contact lithography (OCL) and electron beam (EBL). OCL enables metal feedlines widths 520 nm interconnect spaces 280 nm, while EBL allows realization 50 150 on parylene C substrates. Based these techniques, we fabricate a 64‐channel intracortical implant miniaturized cross‐section only × 6 or 70 µm 2 . In vivo validation in awake rats demonstrates that fabricated, implants submicron offer low‐impedance electrodes crosstalk, enabling reliable neuronal recordings. These findings demonstrate feasibility miniaturizing single‐metal layer process, thereby reducing manufacturing complexity thin‐film polymer‐based interfaces.
Язык: Английский
Процитировано
0
Materials Horizons, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
High-precision neural recording plays a pivotal role in unraveling the intricate mechanisms that underlie information transmission of nervous system, raising increasing interest development implantable microelectrode arrays (MEAs). The challenge lies providing truly soft, highly conductive and low-impedance interface for precise electrophysiological signals individual neurons or networks. Herein, by implementing novel topological regulation strategy silk fibroin (SF) crosslinking, we prepared flexible, hydrophilic, biocompatible MEA substrate, facilitating minimizes mechanical mismatch with biological tissues. Additionally, established involving screen-printing combined post-coating to prepare MEAs high conductivity, low impedance capacitance, coating PEDOT:PSS on titanium carbide (Ti
Язык: Английский
Процитировано
2
Materials, Год журнала: 2024, Номер 17(14), С. 3454 - 3454
Опубликована: Июль 12, 2024
This paper reviews the latest trends and applications of silicone in ophthalmology, especially related to intraocular lenses (IOLs). Silicone, or siloxane elastomer, as a synthetic polymer, has excellent biocompatibility, high chemical inertness, hydrophobicity, enabling wide biomedical applications. The physicochemical properties are reviewed. A review methods for mechanical vivo characterization IOLs is presented prospective research area, since there only few available technologies, even though these vital ensure medical safety suitability clinical use, if long-term function considered. represent permanent implants replace natural lens correcting vision, with first commercial foldable made silicone. Biological aspects posterior capsular opacification have been reviewed, including effects implanted IOL. However, certain issues still challenging some conditions can prevent its application all patients. nanotechnology solutions Surface modifications an efficient approach further improve biocompatibility enable drug-eluting function. Different surface modifications, coatings, provide treatments various diagnoses through incorporation sensory functions. It essential that IOL optical characteristics remain unchanged case drug nanoparticles it. trials advanced technologies missing, thus preventing their at this moment.
Язык: Английский
Процитировано
2
Journal of Materials Chemistry C, Год журнала: 2024, Номер 12(37), С. 14944 - 14954
Опубликована: Янв. 1, 2024
This paper explores the combination of screen-printing and electrogelation PEDOT:PSS, including non-solution-processable PEDOT:PSS-copolymers, to fabricate scalable cost-effective coated devices for bioelectronic applications.
Язык: Английский
Процитировано
2