Small, Год журнала: 2024, Номер unknown
Опубликована: Дек. 10, 2024
Nanozymes mimicking enzymes show great promise in anti-tumor therapy but are often limited by their low catalytic activity and lack of tumor specificity hostile microenvironments. This study develops a novel nanozyme, D/P@ZUCO, utilizing metal-organic frameworks (MOFs) with glutathione oxidase, peroxidase, catalase-like activities. D/P@ZUCO is synthesized using ZnFe
Язык: Английский
Biomaterials, Год журнала: 2024, Номер 311, С. 122675 - 122675
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
29
Advanced Science, Год журнала: 2023, Номер 11(3)
Опубликована: Ноя. 20, 2023
Abstract Cancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host antitumor immune response. However, direct use of inducers or regulators may bring about severe side effects that also be rapidly excreted degraded low efficacy. Nanomaterials able carry them for long circulation time, high tumor accumulation controlled release achieve satisfactory effect. Nowadays, large number studies focused on nanomedicines‐based strategies through modulating modalities potentiate immunity. Herein, types their function first summarized, state‐of‐the‐art research progresses in nanomedicines mediated pathways (e.g., cuproptosis) response provocation highlighted. Subsequently, the conclusion outlook potential focus discussed.
Язык: Английский
Процитировано
24
Nano Today, Год журнала: 2024, Номер 56, С. 102270 - 102270
Опубликована: Апрель 15, 2024
Язык: Английский
Процитировано
14
Advanced Functional Materials, Год журнала: 2024, Номер 34(33)
Опубликована: Май 16, 2024
Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.
Язык: Английский
Процитировано
9
Materials Today Bio, Год журнала: 2024, Номер 26, С. 101028 - 101028
Опубликована: Март 24, 2024
The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.
Язык: Английский
Процитировано
8
Cells, Год журнала: 2024, Номер 13(22), С. 1924 - 1924
Опубликована: Ноя. 20, 2024
Identifying definitive biomarkers that predict clinical response and resistance to immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in the tumor microenvironment (TME), which significantly impairs immune cell function contributes failure. However, acidic conditions TME disrupt interaction between cancer cells, driving tumor-infiltrating T cells NK into an inactivated, anergic state. Simultaneously, promotes recruitment activation of immunosuppressive such as myeloid-derived suppressor regulatory (Tregs). Notably, acidity enhances exosome release from Tregs, further amplifying immunosuppression. Tumor thus acts "protective shield," neutralizing anti-tumor responses transforming pro-tumor allies. Therefore, targeting lactate metabolism has emerged promising strategy overcome this barrier, with approaches including buffer agents neutralize pH inhibitors block production or transport, thereby restoring efficacy TME. Recent discoveries have identified genes involved (pHe) regulation, presenting new therapeutic targets. Moreover, ongoing research aims elucidate molecular mechanisms acidification develop treatments modulate levels enhance outcomes. Additionally, future studies are crucial validate safety pHe-targeted therapies patients. Thus, review explores regulation pHe its potential role improving immunotherapy.
Язык: Английский
Процитировано
8
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional neglect the increase in immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that A2A receptor (A2AR) significantly expressed cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo-based lipid peroxidation (LPO) nanoamplifiers A2AR blockade reported maximize ICD-mediated anti-tumor immunity. This LPO nanoamplifier causes explosion by Fe (II)-mediated Fenton reaction Mo(V)-mediated Russell mechanism. Subsequently, elicits ICD magnification of tumor cells inducing multiple regulated patterns ferroptosis, apoptosis, necroptosis. Additionally, antagonist (SCH58261), an immunometabolic checkpoint blocker, relieve ADO-related immunosuppression, amplify immunological effects, elicit immune memory responses. robust immunity observed primary, distant, pulmonary metastatic, recurrent tumors. study provides novel for optimizing immunotherapy highlights benefits enhance immunotherapy.
Язык: Английский
Процитировано
1
Materials, Год журнала: 2024, Номер 17(12), С. 2896 - 2896
Опубликована: Июнь 13, 2024
Transition metal oxide (TMO)-based nanozymes have appeared as hopeful tools for antitumor applications due to their unique catalytic properties and ability modulate the tumor microenvironment (TME). The purpose of this review is provide an overview latest progress made in field TMO-based nanozymes, focusing on enzymatic activities participating ions. These exhibit catalase (CAT)-, peroxidase (POD)-, superoxide dismutase (SOD)-, oxidase (OXD)-, glutathione (GSH-OXD)-like activities, enabling them regulate reactive oxygen species (ROS) levels (GSH) concentrations within TME. Widely studied transition metals include Fe, Mn, Cu, Ce, hybrid multimetallic oxides, which are also summarized. highlights several innovative nanozyme designs multifunctional capabilities. Despite significant challenges such long-term biosafety, targeting precision, mechanisms, theoretical supports remain be addressed, these discussed. This contributes summary understanding rapid development holds great promise advancing nanomedicine improving cancer treatment.
Язык: Английский
Процитировано
6
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Abstract Pyroptosis, a form of programmed cell death characterized by lysis and inflammation, has significant implications for disease treatment. Nanomaterials (NMs), with their unique physicochemical properties, can precisely modulate pyroptosis, offering novel intelligent therapeutic strategies cancer, infectious diseases, chronic inflammatory conditions targeted activation reduced systemic toxicity. This review explores the mechanisms which NMs regulate comparing molecular NM inducers, examines role intrinsic properties such as size, shape, surface charge, chemical composition in these processes. It also discusses balance between beneficial adverse effects NM‐induced highlighting delivery systems, modifications, controlled to enhance efficacy intelligence while minimizing Notably, mRNA‐based nanomedicine be intelligently designed activate achieving desired outcomes tailored evolving microenvironment diseases. By understanding interactions, potential harnessed develop innovative treatments manage pyroptosis‐associated diseases safely, effectively, intelligently. highlights transformative clinical applications.
Язык: Английский
Процитировано
0