Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 24, 2024
Abstract
Discectomy
serves
as
the
primary
therapeutic
approach
for
lumbar
disc
herniation,
but
annular
fibrosus
defects
after
discectomy
may
lead
to
recurrence
of
herniation.
Despite
recent
advances
in
bioinspired
adhesives
seal
AF
defect,
growing
popularity
endoscopic
has
put
forward
high
requirements
tissue
bioadhesives
with
rapid
injectability,
easy
operation,
and
robust
adhesion
underwater
environments.
Herein,
a
rapidly
situ
forming
injectable
tetra‐PEG
bioadhesive
(ISG)
comprising
FDA‐approved
tetra‐armed
poly
(ethylene
glycol)
amine
(tetra‐PEG‐NH
2
)
succinimidyl
glutarate
(tetra‐PEG‐SG)
sutureless
closure
defects,
is
reported.
Relying
on
quick
ammonolysis
reaction
between
N‐hydroxysuccinimide
(NHS)‐ester
tetra‐PEG‐SG
polymer
groups
tetra‐PEG‐NH
proteins,
uniform
networks
are
formed
within
seconds
injection,
efficient
waterproofness,
instant
adhesion,
durable
compliance.
The
goat
model
was
used
assess
effect
ISG
hydrogels
vivo.
results
reveal
that
resultant
can
effectively
maintain
height,
fuse
host
tissue,
ameliorate
IVD
degeneration,
retain
initial
biomechanics.
Together,
this
study
provides
an
strategy
glue
minimally
invasive
treatment
defects.
Journal of Orthopaedic Translation,
Год журнала:
2025,
Номер
50, С. 129 - 143
Опубликована: Янв. 1, 2025
At
present,
there
is
a
significant
population
of
individuals
experiencing
bone
deficiencies
caused
by
injuries,
ailments
affecting
the
bones,
congenital
abnormalities,
and
cancer.
The
management
substantial
defects
global
orthopedic
challenge
due
to
intricacies
involved
in
promoting
restoring
growth
fresh
osseous
tissue.
Autografts
are
widely
regarded
as
"gold
standard"
for
repairing
because
their
superior
tissue
acceptance
ability
control
osteogenesis.
However,
patients
undergoing
autografts
may
encounter
various
challenges,
including
but
not
limited
hernia,
bleeding,
nerve
impairment,
death.
Therefore,
researchers
regenerative
medicine
striving
find
alternatives.
Collagen
most
abundant
protein
human
body,
its
triple
helix
structure
gives
it
unique
characteristics
that
contribute
strength
functionality
tissues.
commonly
processed
into
forms
such
scaffolds,
sponges,
membranes,
hydrogels,
composite
materials,
compatibility
with
affinity
water,
minimal
potential
immune
reactions,
adaptability,
transport
nutrients
or
drugs.
As
an
alternative
material
field
regeneration,
collagen
becoming
increasingly
important.
objective
this
review
provide
comprehensive
analysis
primary
types
sources
collagen,
processes
synthesis
degradation,
well
advancements
made
regeneration
research
applications.
A
investigation
role
undertaken,
providing
valuable
points
reference
more
profound
comprehension
applications
field.
concluding
section
provides
overview
prospective
avenues
research,
underscoring
promising
future
highlighting
regeneration.
Translational
Potential
Article.
exploration
diverse
functions
translational
demonstrated
review,
these
findings
underscore
treatment
option
clinical
implications,
thus
paving
way
innovative
efficacious
therapeutic
strategies
domain.
Abstract
Inflammation‐responsive
hydrogels
loaded
with
therapeutic
factors
are
effective
biomaterials
for
bone
tissue
engineering
and
regenerative
medicine.
In
this
study,
a
matrix
metalloproteinase
(MMP)‐responsive
injectable
hydrogel
is
constructed
by
integrating
an
MMP‐cleavable
peptide
(pp)
into
covalent
tetra‐armed
poly‐(ethylene
glycol)
(PEG)
network
precise
drug
release
upon
inflammation
stimulation.
To
establish
pro‐regenerative
environment,
phosphatidylserine
(PS)
encapsulated
scaffold
to
form
the
PEG‐pp‐PS
network,
which
could
be
triggered
MMP
large
amount
of
PS
during
early
stage
retain
persistently
until
later
repair.
The
found
mechanically
biologically
adaptable
complex
defect
area.
vivo
in
vitro
studies
further
demonstrated
ability
transform
macrophages
anti‐inflammatory
M2
phenotype
promote
osteogenic
differentiation,
thus,
resulting
new
regeneration.
Therefore,
study
provides
facile,
safe,
promising
cell‐free
strategy
on
simultaneous
immunoregulation
osteoinduction
engineering.
Therapeutic Delivery,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Янв. 27, 2025
Natural
hydrogels
have
garnered
increasing
attention
due
to
their
natural
origins
and
beneficial
roles
in
wound
healing.
Hydrogel
water-retaining
capacity
excellent
biocompatibility
create
an
ideal
moist
environment
for
healing,
thereby
enhancing
cell
proliferation
tissue
regeneration.
For
this
reason,
naturally
derived
formulated
from
biomaterials
such
as
chitosan,
alginate,
gelatin,
fibroin
are
highly
promising
biodegradability
low
immunogenic
responses.
Recent
integrated
approaches
utilizing
new
technologies
with
bioactive
agents
significantly
improved
the
mechanical
properties
of
controlled
release
delivery
active
compounds,
efficiency
treatment
processes.
Herein,
review
highlights
advantages
challenges
focusing
on
strength,
degradation
rates,
safety
validation,
potential
incorporating
advanced
engineering
gene
therapy
utilization
personalized
medicine.
Bioactive Materials,
Год журнала:
2024,
Номер
37, С. 439 - 458
Опубликована: Апрель 25, 2024
Facile
and
rapid
3D
fabrication
of
strong,
bioactive
materials
can
address
challenges
that
impede
repair
large-to-massive
rotator
cuff
tears
including
personalized
grafts,
limited
mechanical
support,
inadequate
tissue
regeneration.
Herein,
we
developed
a
facile
methodology
generates
visible
light-crosslinkable
polythiourethane
(PHT)
pre-polymer
resin
(∼30
min
at
room
temperature),
yielding
3D-printable
scaffolds
with
tendon-like
attributes
capable
delivering
tenogenic
factors.
Ex
vivo
characterization
confirmed
successful
fabrication,
robust
human
supraspinatus
tendon
(SST)-like
tensile
properties
(strength:
23
MPa,
modulus:
459
least
10,000
physiological
loading
cycles
without
failure),
excellent
suture
retention
(8.62-fold
lower
than
acellular
dermal
matrix
(ADM)-based
clinical
graft),
slow
degradation,
controlled
release
fibroblast
growth
factor-2
(FGF-2)
transforming
factor-β3
(TGF-β3).
In
vitro
studies
showed
cytocompatibility
factor-mediated
tenogenic-like
differentiation
mesenchymal
stem
cells.
demonstrated
biocompatibility
(3-week
mouse
subcutaneous
implantation)
ability
factor-containing
to
notably
regenerate
1-cm
native-like
biomechanical
as
uninjured
shoulder
(8-week,
gap
rabbit
injury).
This
study
demonstrates
use
3D-printable,
material
provide
support
pro-regenerative
cues
for
challenging
injuries
such
tears.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Effective
bone
defect
repair
has
been
a
tough
clinical
challenge
due
to
the
complexity
of
microenvironment.
Hydrogels
loaded
with
marrow
mesenchymal
stem
cells
(BMSCs)
have
widely
applied
for
regeneration.
However,
low
survival
BMSCs
at
site
transplantation
and
lack
sufficient
osteogenic
induction
capacity
greatly
limit
their
applications.
In
order
solve
this
puzzle,
we
fabricated
gelatin
methacryloyl
(GelMA)
hydrogels
containing
cerium
oxide
(CeO
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101374 - 101374
Опубликована: Дек. 1, 2024
The
treatment
of
large
bone
defects
remains
challenging
due
to
the
lack
spatiotemporal
management
immune
microenvironment,
inflammation
response
and
remodeling.
To
address
these
issues,
we
designed
developed
a
nanoparticle/hydrogel
hybrid
system
that
can
achieve
combined
sequential
delivery
an
anti-inflammatory
factor
(IL-10)
osteogenic
drug
(icariin,
ICA).
A
photopolymerizable
composite
hydrogel
was
prepared
by
combining
gelatin
methacryloyl
(GelMA)
heparin-based
acrylated
hyaluronic
acid
(HA)
hydrogels
containing
IL-10,
poly(dl-lactide-co-glycolide)
(PLGA)-HA
nanoparticles
loaded
with
ICA
were
incorporated
into
hydrogels.
demonstrates
array
features
including
mechanical
strength,
injectability
photo-crosslinking.
rapid
release
IL-10
from
effectively
exerts
immunomodulatory
activity,
whereas
long-term
sustained
icariin
PLGA-HA
significantly
triggers
differentiation
marrow-derived
mesenchymal
stem
cells
(BMSCs).
Notably,
exhibit
synergistic
effect
for
remodeling
in
critical
cranial
defect
rat
model.
Our
findings
indicate
importance
microenvironment
high-quality
skull
remodeling,
thus
dual-factor
releasing
could
be
promising
candidate
repairing
defects.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Since
the
diseases
that
cause
bone
defects
are
mostly
inflammatory
diseases,
current
grafts
unable
to
effectively
regulate
osteoimmune
activity,
leading
impaired
osteogenesis
and
unfavorable
regeneration.
In
this
study,
inspired
by
composition,
biomimetic
mesoporous
bioactive
glass
nanoparticle
(MBG)/bovine
serum
albumin
(BSA)
designed
for
defects.
Systematically,
MBG/BSA
evaluated
characterization,
bioactivity,
anti‐inflammatory,
antioxidant
osteogenic
activity.
proved
be
biocompatible
can
release
ions
including
calcium
silicon
in
a
sustained
manner.
Furthermore,
reprograms
macrophage
phenotype
toward
anti‐inflammation
is
beneficial
The
antioxidative
activity
also
validated
under
inflammation
mechanism
may
via
interleukin‐4
(IL‐4)/Signal
transducer
activator
of
transcription
6
(STAT6)
pathway.
differentiation
mineralization
facilitated
due
improved
immunoregulation
MBG/BSA.
Overall,
work
suggests
with
immunomodulatory
properties
an
ideal
material
regeneration
application.
