Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 24, 2024

Abstract Discectomy serves as the primary therapeutic approach for lumbar disc herniation, but annular fibrosus defects after discectomy may lead to recurrence of herniation. Despite recent advances in bioinspired adhesives seal AF defect, growing popularity endoscopic has put forward high requirements tissue bioadhesives with rapid injectability, easy operation, and robust adhesion underwater environments. Herein, a rapidly situ forming injectable tetra‐PEG bioadhesive (ISG) comprising FDA‐approved tetra‐armed poly (ethylene glycol) amine (tetra‐PEG‐NH 2 ) succinimidyl glutarate (tetra‐PEG‐SG) sutureless closure defects, is reported. Relying on quick ammonolysis reaction between N‐hydroxysuccinimide (NHS)‐ester tetra‐PEG‐SG polymer groups tetra‐PEG‐NH proteins, uniform networks are formed within seconds injection, efficient waterproofness, instant adhesion, durable compliance. The goat model was used assess effect ISG hydrogels vivo. results reveal that resultant can effectively maintain height, fuse host tissue, ameliorate IVD degeneration, retain initial biomechanics. Together, this study provides an strategy glue minimally invasive treatment defects.

Язык: Английский