Recent Advances in Biomimetic Strategies for the Immunotherapy of Glioblastoma
Biomaterials,
Год журнала:
2024,
Номер
311, С. 122694 - 122694
Опубликована: Июнь 28, 2024
Язык: Английский
Bacteria Synergized with PD‐1 Blockade Enhance Positive Feedback Loop of Cancer Cells‐M1 Macrophages‐T Cells in Glioma
Advanced Science,
Год журнала:
2024,
Номер
11(20)
Опубликована: Март 23, 2024
Abstract
Cancer
immunotherapy
is
an
attractive
strategy
because
it
stimulates
immune
cells
to
target
malignant
by
regulating
the
intrinsic
activity
of
system.
However,
due
lacking
many
immunologic
markers,
remains
difficult
treat
glioma,
a
representative
“cold”
tumor.
Herein,
wake
“hot”
tumor
immunity
Porphyromonas
gingivalis
(Pg)
customized
with
coating
create
immunogenic
microenvironment
and
further
prove
effect
in
combination
checkpoint
agent
anti‐PD‐1,
exhibiting
elevated
therapeutic
efficacy.
This
accomplished
not
enhancing
delivery
PD‐1
blockade
enhance
immunotherapy,
but
introducing
bacterial
photothermal
therapy
promote
greater
involvement
M1
response.
After
reaching
bacteria
glioma
M2
phenotype
macrophages
selectively,
enabling
precise
conversion
for
lysing
macrophages,
which
thereby
enhances
positive
feedback
loop
cancer
cells‐M1
macrophages‐T
cells.
Collectively,
synergized
may
be
key
overcoming
immunosuppressive
improving
outcome
toward
glioma.
Язык: Английский
Biochemical Strategy-Based Hybrid Hydrogel Dressing-Mediated In Situ Synthesis of Selenoproteins for DFU Immunity-Microbiota Homeostasis Regulation
Biomaterials,
Год журнала:
2025,
Номер
317, С. 123114 - 123114
Опубликована: Янв. 21, 2025
Язык: Английский
Targeting of Low‐Immunogenic Poly(ethylene glycol) Nanoparticles for Photothermal‐Enhanced Immunotherapy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Abstract
The
assembly
of
low‐immunogenic
poly(ethylene
glycol)
nanoparticles
(PEG
NPs)
for
targeted
delivery
therapeutics
(i.e.,
mitoxantrone
and
imidazoquinoline)
improved
photothermal‐immunotherapy
is
reported.
PEG
NPs
incorporating
targeting
molecules
hyaluronic
acid
are
engineered
via
the
templating
metal–organic
frameworks,
which
can
circumvent
accelerated
blood
clearance
exhibit
prolonged
circulation
time
as
well
accumulation
at
tumor
sites.
under
laser
radiation
induces
immunogenic
cell
death
cells,
combined
with
toll‐like
receptor
7/8
agonists
imidazoquinoline
to
trigger
immune
responses
cytotoxic
T
lymphocytes
eradication
cells.
Furthermore,
treatment
induce
tumor‐specific
that
inhibit
metastatic
lung
growth.
This
reported
provide
a
rational
design
cancer
immunotherapy.
Язык: Английский
Biochemical Strategy-Based Hybrid Hydrogel Dressing-Mediated in Situ Synthesis of Selenoproteins for Dfu Immunity-Microbiota Homeostasis Regulation
Опубликована: Янв. 1, 2024
Язык: Английский
Unveiling the significance of cancer-testis antigens and their implications for immunotherapy in glioma
Discover Oncology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 29, 2024
Язык: Английский
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Bacteria
and
their
derivatives
show
great
potential
as
drug
delivery
systems
due
to
unique
chemotaxis,
biocompatibility,
targeting
abilities.
In
CNS
disease
treatment,
bacterial
carriers
can
cross
the
blood-brain
barrier
(BBB)
deliver
drugs
precisely,
overcoming
limitations
of
traditional
methods.
Advances
in
genetic
engineering,
synthetic
biology,
nanotechnology
have
transformed
these
into
multifunctional
platforms
for
personalized
treatment.
Язык: Английский