Tumor-Specific Liquid Metal Nitric Oxide Nanogenerator for Enhanced Breast Cancer Therapy
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
20(2), С. 101018 - 101018
Опубликована: Янв. 10, 2025
Nitric
oxide
(NO)
modulates
several
cancer-related
physiological
processes
and
has
advanced
the
development
of
green
methods
for
cancer
treatment
integrated
platforms
combination
or
synergistic
therapies.
Although
a
nanoengineering
strategy
been
proposed
to
overcome
deficiencies
NO
gas
small
donor
molecules,
such
as
short
half-life,
lipophilicity,
non-selectivity,
poor
stability,
it
remains
challenging
prepare
nanomedicines
with
simple
composition,
multiple
functions
enhanced
therapeutic
efficacy.
Herein,
we
build
liquid
metal
nanodroplet
(LMND)-based
nanogenerator
(LMND@HSG)
that
is
stabilized
by
bioreducible
guanylated
hyperbranched
poly(amido
amine)
(HSG)
ligand.
Mechanically,
tumor
microenvironment
specifically
triggers
cascade
process
glutathione
elimination,
reactive
oxygen
species
(ROS)
generation,
release.
According
actual
demand,
ROS
concentrations
could
be
readily
controlled
tuning
LMND
HSG
feed
amounts.
Along
intrinsic
anticancer
property
(ROS-mediated
apoptosis
anti-angiogenesis),
LMND@HSG
administration
further
enhance
growth
suppression
compared
alone.
From
this
study,
leveraging
therapy
provides
more
possibilities
prospect
LMND-based
nanomedicines.
Язык: Английский
Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors
Biomaterials,
Год журнала:
2025,
Номер
319, С. 123180 - 123180
Опубликована: Фев. 13, 2025
Язык: Английский
Exosomes in the Chemoresistance of Glioma: Key Point in Chemoresistance
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(4)
Опубликована: Фев. 1, 2025
ABSTRACT
Gliomas
are
the
most
ordinary
primary
virulent
brain
tumours
and
commonly
used
clinical
treatments
include
tumour
resection,
radiation
therapy
chemotherapy.
Although
significant
progress
has
been
made
in
recent
years
progression‐free
survival
(PFS)
overall
(OS)
for
patients
with
high‐grade
gliomas,
prognosis
remains
poor.
Chemoresistance
refers
to
phenomenon
of
decreased
sensitivity
cells
drugs,
resulting
reduced
or
ineffective
drug
efficacy,
is
an
important
cause
failure
Exosomes,
a
type
extracellular
vesicle,
secreted
by
cancer
various
stromal
microenvironment
(TME)
transfer
their
inclusions
cells,
increasing
chemoresistance.
Furthermore,
depletion
exosomes
reverses
certain
detrimental
effects
on
metabolism
restores
chemotherapeutic
agents.
Here,
we
summarised
correlation
between
resistance
agents
glioma
patients,
mechanisms
action
involved
value.
We
aimed
afford
new
thoughts
research,
diagnosis
intervention
chemoresistance
patients.
Язык: Английский
Engineered Bacterial Outer Membrane Vesicles‐Based Doxorubicin and CD47‐siRNA Co‐Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Apart
from
the
blood‐brain
barrier
(BBB),
efficacy
of
immunotherapy
for
glioblastoma
(GBM)
is
limited
by
presence
intrinsic
and
adaptive
immune
resistance,
implying
that
co‐delivery
various
immunotherapeutic
agents
or
simultaneous
regulation
different
cells
urgently
needed.
Bacterial
outer
membrane
vesicles
(OMVs)
offer
a
unique
advantage
in
treatment
GBM,
owing
to
their
multifunctional
properties
as
carriers
adjuvants
ability
cross
BBB.
However,
traditional
OMVs
can
lead
toxic
side
effects
disruption
tight
junctions
Therefore,
enhance
vivo
safety
targeting
capability
OMVs,
we
introduced
engineered
reduce
toxicity
further
constructed
modularly
assembled
nanoplatform
performing
simple
peptide
modifications.
This
demonstrates
satisfactory
biosafety
able
continuously
BBB
target
GBM
with
assistance
Angiopep‐2.
Subsequently,
immunogenic
substances
on
along
carried
small‐interfering
RNA
(siRNA)
doxorubicin,
promote
reprogramming
phagocytic
abilities
macrophages
microglia,
respectively,
increase
immunogenicity
ultimately
overcoming
resistance
immunotherapy.
OMVs‐based
provides
new
paradigm
insights
into
development
GBM.
Язык: Английский
Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Abstract
Glioblastoma
multiforme
(GBM)
is
one
of
the
most
lethal
malignant
brain
tumors
in
central
nervous
system.
Patients
face
many
challenges
after
surgery,
including
tumor
recurrence,
intracranial
pressure
increase
due
to
cavitation,
and
limitations
associated
with
immediate
postoperative
oral
chemotherapy.
Here
an
injected
peptide
gel
situ
immunostimulatory
functions
developed
coordinate
regulation
glutamine
metabolism
chemodynamic
therapy
for
overcoming
these
obstacles.
The
methodology
entails
crafting
injectable
scaffolds
short
molecules,
incorporating
glutaminase
inhibitor
CB‐839
copper
self‐assembled
particles
(Cu‐His
NPs)
renowned
their
(CDT)
efficacy.
By
fine‐tuning
glutamic
acid
production
via
metabolic
pathways,
this
system
not
only
heightens
therapeutic
prowess
CDT
but
also
escalates
intracellular
oxidative
stress.
This
dual
mechanism
culminates
augmented
immunogenic
cell
death
within
glioblastoma
cells
improves
a
conducive
immune
microenvironment.
Based
on
concept
reprogramming,
treatment
strategy
has
great
potential
significantly
reduce
GBM
recurrence
prolong
median
survival
murine
models.
Язык: Английский
Hierarchical Targeting Nanoplatform for NIR‐II Photoacoustic Imaging and Photo‐Activated Synergistic Immunotherapy of Glioblastoma
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Glioblastoma
(GBM)
stands
as
the
most
aggressive
malignant
brain
tumor,
characterized
by
poor
prognosis,
high
recurrence
rate,
and
resistance
to
multiple
therapies,
posing
a
significant
clinical
challenge.
Here,
hierarchical
targeting
platform
is
presented
for
NIR‐II
photoacoustic
(PA)
imaging‐guided
photo‐chemo
synergistic
immunotherapy
of
GBM.
A
new
molecular
probe
developed
with
exceptional
light‐harvesting
capabilities
enhanced
motion,
boosting
both
photothermal
conversion
PA
signal.
This
probe,
combined
thermo‐responsive
prodrug,
assembled
into
nanoparticles
that
are
further
camouflaged
tumor
cell
membranes
bioorthogonally
modified
transferrin‐mimicking
peptide,
facilitating
blood‐brain
barrier
penetration
GBM
targeting.
High‐contrast
imaging
allows
precise
detection
delineation
GBM,
providing
accurate
guidance
subsequent
treatment.
The
light‐triggered
effect,
coupled
hyperthermia‐activated
significantly
induces
immunogenic
death,
enhancing
tumor‐killing
efficiency
amplifying
anti‐tumor
immune
response.
self‐synergistic
not
only
stimulates
robust
immunity
inhibits
primary
growth
but
also
prevents
post‐surgical
recurrence,
prolonging
survival
time.
work
exemplifies
novel
paradigm
tackling
diagnostic
therapeutic
challenges
posed
deeply
seated
poorly
tumors.
Язык: Английский
Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 24, 2024
Abstract
Biomimetic
mineralized
collagen
(BMC)
scaffolds
represent
an
innovative
class
of
bone‐repair
biomaterials
inspired
by
the
natural
biomineralization
process
in
bone
tissue.
Owing
to
their
favorable
biocompatibility
and
mechanical
properties,
BMC
have
garnered
significant
attention
tissue
engineering.
However,
most
studies
overlooked
importance
bioactivity,
resulting
with
suboptimal
osteogenic
potential.
In
this
review,
composition
extracellular
matrix
(ECM)
is
discussed
provide
guidance
for
biomimetic
mineralization.
Subsequently,
according
detailed
fabrication
procedure
scaffolds,
substances
that
can
regulate
both
biological
activities
summarized.
Furthermore,
a
potential
strategy
developing
superior
properties
engineering
proposed.
Язык: Английский
Extracellular nanovesicles as neurotherapeutics for central nervous system disorders
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 7, 2024
Introduction
The
blood-brain
barrier
(BBB)
is
a
highly
selective
structure
that
protects
the
central
nervous
system
(CNS)
while
hindering
delivery
of
many
therapeutic
agents.
This
presents
major
challenge
in
treating
neurological
disorders,
such
as
multiple
sclerosis,
where
effective
drug
to
brain
crucial
for
improving
patient
outcomes.
Innovative
strategies
are
urgently
needed
address
this
limitation.
Язык: Английский