Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Язык: Английский
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
519, С. 216122 - 216122
Опубликована: Авг. 6, 2024
Язык: Английский
A Membrane‐Targeting Aggregation‐Induced Emission Probe for Monitoring Lipid Droplet Dynamics in Ischemia/Reperfusion‐Induced Cardiomyocyte Ferroptosis
Advanced Science,
Год журнала:
2024,
Номер
11(26)
Опубликована: Май 2, 2024
Myocardial
ischemia/reperfusion
injury
(MIRI)
is
the
leading
cause
of
irreversible
myocardial
damage.
A
pivotal
pathogenic
factor
(I/R)-induced
cardiomyocyte
ferroptosis,
marked
by
iron
overload
and
lipid
peroxidation.
However,
impact
droplet
(LD)
changes
on
I/R-induced
ferroptosis
unclear.
In
this
study,
an
aggregation-induced
emission
probe,
TPABTBP
developed
that
used
for
imaging
dynamic
in
LD
during
ferroptosis.
exhibits
excellent
LD-specificity,
superior
capability
monitoring
lipophagy,
remarkable
photostability.
Molecular
dynamics
(MD)
simulation
super-resolution
fluorescence
demonstrate
specifically
localized
to
phospholipid
monolayer
membrane
LDs.
Imaging
LDs
cardiomyocytes
tissue
model
mice
with
MIRI
reveals
accumulation
level
increase
early
reperfusion
stage
(0-9
h)
but
decrease
late
(>24
via
lipophagy.
The
inhibition
breakdown
significantly
reduces
peroxidation
cardiomyocytes.
Furthermore,
it
demonstrated
chloroquine
(CQ),
FDA-approved
autophagy
modulator,
can
inhibit
thereby
attenuating
mice.
This
study
describes
ischemia
suggests
a
potential
therapeutic
target
intervention.
Язык: Английский
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
Journal of Cardiovascular Translational Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Язык: Английский
Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects
Bone Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Фев. 25, 2025
Abstract
The
muscular
system
plays
a
critical
role
in
the
human
body
by
governing
skeletal
movement,
cardiovascular
function,
and
activities
of
digestive
organs.
Additionally,
muscle
tissues
serve
an
endocrine
function
secreting
myogenic
cytokines,
thereby
regulating
metabolism
throughout
entire
body.
Maintaining
requires
iron
homeostasis.
Recent
studies
suggest
that
disruptions
ferroptosis,
form
iron-dependent
cell
death,
are
essential
contributors
to
progression
wide
range
diseases
disorders,
including
sarcopenia,
cardiomyopathy,
amyotrophic
lateral
sclerosis.
Thus,
comprehensive
overview
mechanisms
ferroptosis
these
conditions
is
crucial
for
identifying
potential
therapeutic
targets
developing
new
strategies
disease
treatment
and/or
prevention.
This
review
aims
summarize
recent
advances
understanding
molecular
underlying
context
injury,
as
well
associated
disorders.
Moreover,
we
discuss
within
pathway
possible
managing
Finally,
shed
light
on
current
limitations
future
prospects
interventions
targeting
ferroptosis.
Язык: Английский
Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction
Xin Zhang,
Shuai Shao,
Qiuting Li
и другие.
Reviews in Cardiovascular Medicine,
Год журнала:
2025,
Номер
26(3)
Опубликована: Март 24, 2025
This
review
examines
the
mechanisms
of
left
ventricular
dysfunction,
focusing
on
interplay
between
remodeling,
autophagy,
and
mitochondrial
dysfunction
following
myocardial
infarction.
Left
directly
affects
heart's
pumping
efficiency
can
lead
to
severe
clinical
outcomes,
including
heart
failure.
After
infarction,
ventricle
may
suffer
from
weakened
contractility,
diastolic
cardiac
progressing
Thus,
this
article
discusses
pathophysiological
processes
involved
in
injury
repair
infarcted
non-infarcted
myocardia,
adaptive
changes,
specific
changes
systolic
functions.
Furthermore,
role
autophagy
maintaining
cellular
energy
homeostasis,
clearing
dysfunctional
mitochondria,
key
failure
is
addressed.
Finally,
therapeutic
strategies
targeting
enhancing
mitophagy,
providing
clinicians
researchers
with
latest
insights
future
research
directions.
Язык: Английский