Engineering 3D Scaffold‐Free Nanoparticle‐Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function
Advanced Science,
Год журнала:
2024,
Номер
11(40)
Опубликована: Июль 25, 2024
Electrical
stimulation
(ES)
of
cellular
systems
can
be
utilized
for
biotechnological
applications
and
electroceuticals
(bioelectric
medicine).
Neural
cell
especially
has
a
long
history
in
neuroscience
research
is
increasingly
applied
clinical
therapies.
Application
ES
via
conventional
electrodes
requires
external
connectors
power
sources,
hindering
scientific
therapeutic
applications.
Here
engineering
novel
3D
scaffold-free
human
neural
stem
constructs
with
integrated
piezoelectric
nanoparticles
enhanced
tissue
induction
function
described.
Tetragonal
barium
titanate
(BaTi03)
are
employed
as
stimulators
prepared
cytocompatible
dispersions,
incorporated
into
self-organizing
spheroids,
activated
wirelessly
by
ultrasound.
Ultrasound
delivery
(low
frequency;
40
kHz)
optimized
survival,
nanoparticle
activation
enabled
throughout
the
spheroids
during
differentiation,
formation,
maturation.
The
resultant
tissues
represent
first
example
direct
loading
particles
ensuing
ultrasound-mediated
enhancement
neuronal
from
cells,
including
augmented
neuritogenesis
synaptogenesis.
It
anticipated
that
platform
described
will
facilitate
advanced
vitro
modeling
(and
potentially
non-neural)
tissues,
development
pathology,
applicable
to
preclinical
testing
prototyping
both
pharmaceuticals.
Язык: Английский
Exogenous Electron Generation Techniques for Biomedical Applications: Bridging Fundamentals and Clinical Practice
Biomaterials,
Год журнала:
2025,
Номер
317, С. 123083 - 123083
Опубликована: Янв. 5, 2025
Язык: Английский
Titanium-based nanoparticles: innovations in energy applications, wastewater treatment, and tissue engineering for cardiac regeneration
Discover Chemistry.,
Год журнала:
2025,
Номер
2(1)
Опубликована: Апрель 2, 2025
Язык: Английский
Emerging Functional Porous Scaffolds for Liver Tissue Engineering
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
Abstract
Liver
tissue
engineering
holds
promising
in
synthesizing
or
regenerating
livers,
while
the
design
of
functional
scaffold
remains
a
challenge.
Owing
to
intricate
simulation
extracellular
matrix
structure
and
performance,
porous
scaffolds
have
demonstrated
advantages
creating
liver
microstructures
sustaining
functions.
Currently,
various
methods
processes
been
employed
fabricate
scaffolds,
manipulating
properties
morphologies
materials
confer
them
with
unique
supportive
Additionally,
must
also
facilitate
growth
deliver
cells,
possessing
therapeutic
regenerative
effects.
In
this
review,
it
is
initially
outline
typical
procedures
for
fabricating
showcase
microstructures.
Subsequently,
delved
into
forms
cell
loading
including
scaffold‐based,
scaffold‐free,
synergetic
bioassembly
approaches.
Lastly,
utilization
diseases,
offering
significant
insights
future
implications
regeneration
research
explored.
Язык: Английский