Emerging Functional Porous Scaffolds for Liver Tissue Engineering DOI Open Access
Jinglin Wang, Danqing Huang, Dayu Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Abstract Liver tissue engineering holds promising in synthesizing or regenerating livers, while the design of functional scaffold remains a challenge. Owing to intricate simulation extracellular matrix structure and performance, porous scaffolds have demonstrated advantages creating liver microstructures sustaining functions. Currently, various methods processes been employed fabricate scaffolds, manipulating properties morphologies materials confer them with unique supportive Additionally, must also facilitate growth deliver cells, possessing therapeutic regenerative effects. In this review, it is initially outline typical procedures for fabricating showcase microstructures. Subsequently, delved into forms cell loading including scaffold‐based, scaffold‐free, synergetic bioassembly approaches. Lastly, utilization diseases, offering significant insights future implications regeneration research explored.

Language: Английский

Engineering 3D Scaffold‐Free Nanoparticle‐Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function DOI Creative Commons
Emma Claire James, Eva Tomaskovic‐Crook, Jeremy M. Crook

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(40)

Published: July 25, 2024

Electrical stimulation (ES) of cellular systems can be utilized for biotechnological applications and electroceuticals (bioelectric medicine). Neural cell especially has a long history in neuroscience research is increasingly applied clinical therapies. Application ES via conventional electrodes requires external connectors power sources, hindering scientific therapeutic applications. Here engineering novel 3D scaffold-free human neural stem constructs with integrated piezoelectric nanoparticles enhanced tissue induction function described. Tetragonal barium titanate (BaTi03) are employed as stimulators prepared cytocompatible dispersions, incorporated into self-organizing spheroids, activated wirelessly by ultrasound. Ultrasound delivery (low frequency; 40 kHz) optimized survival, nanoparticle activation enabled throughout the spheroids during differentiation, formation, maturation. The resultant tissues represent first example direct loading particles ensuing ultrasound-mediated enhancement neuronal from cells, including augmented neuritogenesis synaptogenesis. It anticipated that platform described will facilitate advanced vitro modeling (and potentially non-neural) tissues, development pathology, applicable to preclinical testing prototyping both pharmaceuticals.

Language: Английский

Citations

4
Exogenous Electron Generation Techniques for Biomedical Applications: Bridging Fundamentals and Clinical Practice DOI
Yufei Tang, Shuqi Feng, Keyi Yao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123083 - 123083

Published: Jan. 5, 2025

Language: Английский

Citations

0
Titanium-based nanoparticles: innovations in energy applications, wastewater treatment, and tissue engineering for cardiac regeneration DOI Creative Commons
Ikhazuagbe H. Ifijen,

Uchenna Uzoma Akobundu,

Janefrances U. Chukwu

et al.

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: April 2, 2025

Language: Английский

Citations

0
Emerging Functional Porous Scaffolds for Liver Tissue Engineering DOI Open Access
Jinglin Wang, Danqing Huang, Dayu Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Abstract Liver tissue engineering holds promising in synthesizing or regenerating livers, while the design of functional scaffold remains a challenge. Owing to intricate simulation extracellular matrix structure and performance, porous scaffolds have demonstrated advantages creating liver microstructures sustaining functions. Currently, various methods processes been employed fabricate scaffolds, manipulating properties morphologies materials confer them with unique supportive Additionally, must also facilitate growth deliver cells, possessing therapeutic regenerative effects. In this review, it is initially outline typical procedures for fabricating showcase microstructures. Subsequently, delved into forms cell loading including scaffold‐based, scaffold‐free, synergetic bioassembly approaches. Lastly, utilization diseases, offering significant insights future implications regeneration research explored.

Language: Английский

Citations

0