Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms
Reviews in the Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
Depression
is
a
common
mental
disorder
characterized
by
high
prevalence
and
significant
adverse
effects,
making
the
searching
for
effective
interventions
an
urgent
priority.
In
recent
years,
physical
activity
(PA)
has
increasingly
been
recognized
as
standard
adjunctive
treatment
disorders
owing
to
its
low
cost,
easy
application,
efficiency.
Epidemiological
data
shows
positive
preventive
therapeutic
effects
of
PA
on
illnesses
such
depression.
This
article
systematically
describes
prophylactic
depression
biological
basis.
A
comprehensive
literature
analysis
reveals
that
significantly
improves
depressive
symptoms
upregulating
expression
“exerkines”
irisin,
adiponectin,
BDNF
positively
impacting
neuropsychiatric
conditions.
particular,
lactate
could
also
play
critical
role
in
ameliorating
due
findings
about
protein
lactylation
novel
post-transcriptional
modification.
The
suggests
terms
brain
structure,
may
improve
hippocampal
volume,
basal
ganglia
(neostriatum,
caudate-crustal
nucleus)
PFC
density
patients
with
MDD.
summary,
this
study
elucidates
multifaceted
potential
mechanisms
particular
emphasis
roles
various
exerkines.
Future
research
further
investigate
different
types,
intensities,
durations
depression,
well
how
better
integrate
into
existing
strategies
achieve
optimal
outcomes
health
interventions.
Язык: Английский
Wheel‐Running Exercise Alleviates Anxiety‐Like Behavior via Down‐Regulating S‐Nitrosylation of Gephyrin in the Basolateral Amygdala of Male Rats
Ping‐Fen Yang,
Tai‐Lei Nie,
Xia‐Nan Sun
и другие.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 4, 2024
Physical
exercise
has
beneficial
effect
on
anxiety
disorders,
but
the
underlying
molecular
mechanism
remains
largely
unknown.
Here,
it
is
demonstrated
that
physical
can
downregulate
S-nitrosylation
of
gephyrin
(SNO-gephyrin)
in
basolateral
amygdala
(BLA)
to
exert
anxiolytic
effects.
It
found
level
SNO-gephyrin
significantly
increased
BLA
high-anxiety
rats
and
a
downregulation
at
cysteines
212
284
produced
effect.
Mechanistically,
inhibition
by
either
Cys212
or
Cys284
mutations
surface
expression
GABA
Язык: Английский
S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis
Free Radical Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
The association between weekend warrior physical activity pattern and anxiety: evidence from a U.S. population-based study
BMC Psychiatry,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 25, 2025
This
study
investigates
the
association
between
Weekend
Warrior
(WW)
pattern
and
risk
of
anxiety
among
American
adults,
offering
insights
into
a
more
flexible
exercise
strategy
for
individuals
with
limited
time
regular
during
weekdays.
We
analyzed
data
from
2007–2012
National
Health
Nutrition
Examination
Survey
(NHANES)
to
examine
relationship
different
physical
activity
(PA)
patterns
anxiety.
Multivariate
logistic
regression,
subgroup
interaction,
restricted
cubic
spline
analysis
(RCS),
sensitivity
analyses
were
conducted
assess
this
association.
Compared
inactive
individuals,
those
engaging
in
WW
(OR
=
0.65,
95%
CI:
0.48–0.90,
p
0.010),
insufficiently
active
0.71,
0.62–0.82,
<
0.001),
or
regularly
0.75,
0.65–0.87,
0.001)
showed
significantly
lower
Subgroup
interaction
revealed
significant
effect
modification
poverty
income
ratio
(PIR)
diabetes
subgroups
(P
0.05),
while
no
interactions
observed
other
variables.
RCS
nonlinear
recreational
moderate
vigorous
intensity
0.001).
Sensitivity
further
confirmed
stability
findings.
The
was
associated
For
unable
consistently
throughout
week,
offers
practical
alternative
reducing
anxiety,
particularly
levels
diabetes.
Язык: Английский