Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis
Advanced Materials,
Год журнала:
2024,
Номер
36(48)
Опубликована: Окт. 6, 2024
Rheumatoid
arthritis
(RA)
represents
an
insidious
autoimmune
inflammatory
disorder
that
severely
lowers
the
life
quality
by
progressively
destructing
joint
functions
and
eventually
causing
permanent
disability,
posing
a
serious
public
health
problem.
Here,
advanced
theranostic
probe
is
introduced
integrates
activatable
second
near-infrared
(NIR-II)
fluorescence
imaging
for
precise
RA
diagnosis
with
multi-pronged
treatments.
A
novel
molecular
comprising
long-wavelength
aggregation-induced
emission
unit
manganese
carbonyl
cage
motif
synthesized,
which
enables
NIR-II
activation
concurrently
releasing
therapeutic
carbon
monoxide
(CO)
gas
in
inflamed
microenvironment.
This
self-assembles
into
biocompatible
nanoprobe,
subsequently
conjugated
anti-IL-6R
antibody
to
afford
active-targeting
ability
of
RA.
The
nanoprobe
exhibits
significant
turn-on
signal
at
lesion,
enabling
highly
sensitive
real-time
monitoring.
combination
ROS
scavenging,
on-demand
CO
release,
IL-6
signaling
blockade
results
potent
effect
synergistic
immunomodulation
impact,
significantly
alleviating
symptoms
preventing
destruction.
research
introduces
paradigm
development
high-performance,
strategies
facilitate
detection
enhanced
treatment
RA-related
diseases.
Язык: Английский
Endogenous Melanin and Hydrogen‐Based Specific Activated Theranostics Nanoagents: A Novel Multi‐Treatment Paradigm for Rheumatoid Arthritis
Advanced Science,
Год журнала:
2024,
Номер
11(25)
Опубликована: Апрель 26, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disorder
characterized
by
excessive
proliferation
of
rheumatoid
synovial
fibroblasts
(RASFs)
and
accumulation
inflammatory
cytokines.
Exploring
the
suppression
RASFs
modulation
RA
microenvironment
considered
comprehensive
strategy
for
RA.
In
this
work,
specifically
activated
nanoagents
(MAHI
NGs)
based
on
hypoxic
weakly
acidic
are
developed
to
achieve
second
near‐infrared
fluorescence
(NIR‐II
FL)/photoacoustic
(PA)
dual‐model
imaging‐guided
multi‐treatment.
Due
optimal
size,
MAHI
NGs
passively
accumulate
in
diseased
joint
region
undergo
rapid
responsive
degradation,
precisely
releasing
functionalized
components:
endogenous
melanin‐nanoparticles
(MNPs),
hydrogen
gas
(H
2
),
indocyanine
green
(ICG).
The
released
MNPs
play
crucial
role
ablating
within
through
photothermal
therapy
(PTT)
guided
accurate
PA
imaging.
However,
regional
hyperthermia
generated
PTT
may
exacerbate
reactive
oxygen
species
(ROS)
production
response
following
cell
lysis.
Remarkably,
under
microenvironment,
controlled
release
H
exhibits
precise
synergistic
antioxidant
anti‐inflammatory
effects
with
MNPs.
Moreover,
ICG,
dye
currently
approved
clinical
use,
possesses
excellent
NIR‐II
FL
imaging
properties
that
facilitate
diagnosis
deep
tissue
diseases
provide
right
time‐point
PTT.
Язык: Английский
Optimized indocyanine green nanopreparations for biomedical applications
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
528, С. 216422 - 216422
Опубликована: Янв. 2, 2025
Язык: Английский
Photoacoustic Imaging in Inflammatory Orthopedic Diseases: Progress toward Precise Diagnostics and Predictive Regulation
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Abstract
With
the
intensification
of
aging
issues,
inflammatory
orthopedic
diseases
almost
occur
in
majority
elderly
people,
which
is
becoming
increasingly
severe.
Photoacoustic
imaging
(PAI)
a
non‐invasive
visualization
technique
for
clear
diagnosis
inflammation
areas
through
detecting
acoustic
signals
generated
by
laser
irradiation.
The
combination
“light
input”
and
“acoustic
output”
provides
unprecedented
scalability
as
well
high
penetration
depth
resolution.
This
new
technology
can
also
present
more
anatomical
information
feedback
status
activity
diseases.
Especially
imaging,
this
effectively
supplement
current
clinical
methods
diagnosis,
staging,
monitoring
pathophysiological
processes.
rapid
development
these
technologies,
goals
precise
predictive
regulation,
ultimately
personalized
treatment
strategies
are
realistic.
Herein,
article
introduces
various
inflammations
related
applications.
It
covers
types
PA
nanoprobes
their
research
progress
inflammation,
potential
applications
PAI
aspects.
review
discusses
recent
researches
emerging
translational
prospects
future
challenges
transformation.
Язык: Английский
Bone-Targeted Novel Catalase Nanocapsules for Effective Treatment of Rheumatoid Arthritis
Qian He,
Bangliu Zhao,
Jie Kang
и другие.
Опубликована: Янв. 1, 2025
Язык: Английский
Dramatically Enhancing Multiphoton Harvesting Metal–Organic Frameworks for NIR-II Photocatalysis through Functional Regulation of Octupolar Molecules
L. Y. Zhang,
Bo Li,
Wenyao Duan
и другие.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(36), С. 47348 - 47356
Опубликована: Сен. 2, 2024
The
development
of
effective
multiphoton
absorption
(MPA)
materials
for
near-infrared
(NIR)
light-driven
photocatalysis
holds
great
significance.
In
this
study,
we
incorporated
two
multibranched
cyclometallated
iridium(III)
modules
with
varying
degrees
conjugation
onto
MPA-inert
metal–organic
frameworks
(MOFs)
to
active
MPA
performance.
Subsequently,
the
MOFs
were
further
modified
Co(II)
and
hyaluronic
acid
(HA)
fabricate
MINCH
MISCH,
respectively.
By
introducing
octupolar
molecules
expanding
conjugation,
MISCH
exhibited
a
larger
cross
section
efficient
NIR
light
improved
carrier
transfer,
leading
outstanding
photocatalytic
hydrogen
production.
Moreover,
HA
modification
enabled
achieve
specific
therapy
cancer
cells.
This
study
provides
valuable
insights
into
constructing
highly
photocatalysis,
presenting
potential
platform
in
tumor
treatment.
Язык: Английский