Abstract
DNA
nanostructures
exhibit
versatile
geometries
and
possess
sophisticated
capabilities
not
found
in
other
nanomaterials.
They
serve
as
customizable
nanoplatforms
for
orchestrating
the
spatial
arrangement
of
molecular
components,
such
biomolecules,
antibodies,
or
synthetic
This
is
achieved
by
incorporating
oligonucleotides
into
design
nanostructure.
In
realm
drug
delivery
to
cancer
cells,
there
a
growing
interest
active
targeting
assays
enhance
efficacy
selectivity.
The
approach
involves
“key‐lock”
mechanism
where
carrier,
through
its
ligand,
recognizes
specific
receptors
on
tumor
facilitating
release
drugs.
Various
nanostructures,
including
origami,
Tetrahedral,
nanoflower,
cruciform,
nanostar,
nanocentipede,
nanococklebur,
can
traverse
lipid
layer
cell
membrane,
allowing
cargo
nucleus.
Aptamers,
easily
formed
vitro,
are
recognized
their
targeted
due
high
selectivity
targets
low
immunogenicity.
review
provides
comprehensive
overview
recent
advancements
formation
modification
aptamer‐modified
within
systems.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Synthetic
biology
and
nanotechnology
fusion
represent
a
transformative
approach
promoting
fundamental
clinical
biomedical
science
development.
In
SynBioNanoDesign,
biological
systems
are
reimagined
as
dynamic
programmable
materials
to
yield
engineered
nanomaterials
with
emerging
specific
functionalities.
This
review
elucidates
comprehensive
examination
of
synthetic
biology's
pivotal
role
in
advancing
for
targeted
drug
delivery
systems.
It
begins
exploring
the
synergy
between
nanotechnology,
then
highlights
current
landscape
applications.
Subsequently,
discusses
design
novel
informed
by
principles,
focusing
on
expounding
tools
potential
developing
advanced
nanomaterials.
Afterward,
research
advances
innovative
through
were
systematically
summarized,
emphasizing
integration
genetic
circuitry
program
nanomaterial
responses.
Furthermore,
challenges,
weaknesses
opportunities,
prospective
directions,
ethical
societal
implications
SynBioNanoDesign
elucidated.
Finally,
summarizes
impact
that
may
have
drug-delivery
technologies
future.
The
integration
of
nanomaterials
with
DNA-based
systems
has
emerged
as
a
transformative
approach
in
biosensing
and
therapeutic
applications.
Unique
features
DNA,
like
its
programmability
specificity,
complement
the
diverse
functions
nanomaterials,
leading
to
creation
advanced
for
detecting
biomarkers
delivering
treatments.
Here,
we
review
developments
DNA-nanomaterial
conjugates,
emphasizing
their
enhanced
functionalities
potential
across
various
biomedical
We
first
discuss
methodologies
synthesizing
these
distinguishing
between
covalent
non-covalent
interactions.
then
categorize
DNA-nanomaterials
conjugates
based
on
properties
DNA
involved,
respectively.
probes
are
classified
by
application
into
or
uses,
and,
several
highlighted
recent
progress
living
biological.
Finally,
current
challenges
future
prospects
this
field,
anticipating
that
significant
will
greatly
enhance
precision
medicine.
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(10), С. 3216 - 3227
Опубликована: Сен. 25, 2024
Combination
therapy
has
been
proven
as
an
effective
strategy
for
cancer
treatment.
To
this
end,
we
report
herein
a
self-assembled
nucleic
acid-based
complex
dual
photodynamic
and
antisense
therapy.
It
contains
nucleolin-targeting
As1411-based
G-quadruplex
platform,
partially
hybridized
oligonucleotide
4625,
which
can
inhibit
the
antiapoptotic
protein
B
cell
lymphoma-xL
inducing
apoptotic
death,
zinc(II)
phthalocyanine
(ZnPc)-based
photosensitizer
held
by
noncovalent
interactions.
Through
series
of
in
vitro
experiments,
have
demonstrated
that
DNA
be
internalized
selectively
to
nucleolin-overexpressed
MCF-7
A549
cells
through
receptor-mediated
endocytosis
is
localized
lysosomes.
Upon
light
irradiation,
photosensitization
ZnPc
triggers
formation
reactive
oxygen
species
killing
promotes
lysosomal
escape
4625
The
combined
therapeutic
effect
eliminate
effectively
with
half
maximal
inhibitory
concentration
ca.
0.5
μM.
